Detalhe da pesquisa
1.
Chemical Validation of Mycobacterium tuberculosis Phosphopantetheine Adenylyltransferase Using Fragment Linking and CRISPR Interference.
Angew Chem Int Ed Engl
; 62(17): e202300221, 2023 04 17.
Artigo
Inglês
| MEDLINE | ID: mdl-36757665
2.
Enzyme-Catalyzed Spiroacetal Formation in Polyketide Antibiotic Biosynthesis.
J Am Chem Soc
; 144(32): 14555-14563, 2022 08 17.
Artigo
Inglês
| MEDLINE | ID: mdl-35921248
3.
Structural insights into Escherichia coli phosphopantothenoylcysteine synthetase by native ion mobility-mass spectrometry.
Biochem J
; 476(21): 3125-3139, 2019 11 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31488574
4.
Structure of a soluble epoxide hydrolase identified in Trichoderma reesei.
Biochim Biophys Acta Proteins Proteom
; 1865(8): 1039-1045, 2017 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-28502798
5.
Cloning, expression, purification and biophysical analysis of two putative halogenases from the glycopeptide A47,934 gene cluster of Streptomyces toyocaensis.
Protein Expr Purif
; 132: 9-18, 2017 04.
Artigo
Inglês
| MEDLINE | ID: mdl-28065867
6.
Enzymology of Pyran Ringâ A Formation in Salinomycin Biosynthesis.
Angew Chem Int Ed Engl
; 54(46): 13622-5, 2015 Nov 09.
Artigo
Inglês
| MEDLINE | ID: mdl-26377145
7.
Fragment-Merging Strategies with Known Pyrimidine Scaffolds Targeting Dihydrofolate Reductase from Mycobacterium tuberculosis.
ChemMedChem
; 18(15): e202300240, 2023 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-37195570
8.
Chemical Validation of Mycobacterium tuberculosis Phosphopantetheine Adenylyltransferase Using Fragment Linking and CRISPR Interference.
Angew Chem Weinheim Bergstr Ger
; 135(17): e202300221, 2023 Apr 17.
Artigo
Inglês
| MEDLINE | ID: mdl-38515507
9.
Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis.
Biochem J
; 436(3): 729-39, 2011 Jun 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21410435
10.
Structural basis for the activity and substrate specificity of fluoroacetyl-CoA thioesterase FlK.
J Biol Chem
; 285(29): 22495-504, 2010 Jul 16.
Artigo
Inglês
| MEDLINE | ID: mdl-20430898
11.
Structural and functional characterization of the glutathione peroxidase-like thioredoxin peroxidase from the fungus Trichoderma reesei.
Int J Biol Macromol
; 167: 93-100, 2021 Jan 15.
Artigo
Inglês
| MEDLINE | ID: mdl-33259843
12.
The crystal structure of AjiA1 reveals a novel structural motion mechanism in the adenylate-forming enzyme family.
Acta Crystallogr D Struct Biol
; 76(Pt 12): 1201-1210, 2020 Dec 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33263326
13.
Using a Fragment-Based Approach to Identify Alternative Chemical Scaffolds Targeting Dihydrofolate Reductase from Mycobacterium tuberculosis.
ACS Infect Dis
; 6(8): 2192-2201, 2020 08 14.
Artigo
Inglês
| MEDLINE | ID: mdl-32603583
14.
Mycobacterial OtsA Structures Unveil Substrate Preference Mechanism and Allosteric Regulation by 2-Oxoglutarate and 2-Phosphoglycerate.
mBio
; 10(6)2019 11 26.
Artigo
Inglês
| MEDLINE | ID: mdl-31772052
15.
Structural and functional characterization of the glutathione peroxidase-like thioredoxin peroxidase from the fungus Trichoderma reesei
Int J Biol Macromol, v. 167, p. 93-100, jan. 2021
Artigo
Inglês
| SES-SP, SES SP - Instituto Butantan, SES-SP | ID: bud-3507
16.
Enzymology of Pyran Ringâ A Formation in Salinomycin Biosynthesis.
Angew Chem Weinheim Bergstr Ger
; 127(46): 13826-13829, 2015 Nov 09.
Artigo
Inglês
| MEDLINE | ID: mdl-27587902
17.
Design and structural analysis of aromatic inhibitors of type II dehydroquinase from Mycobacterium tuberculosis.
ChemMedChem
; 10(1): 116-33, 2015 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-25234229
18.
Unsaturated fatty acids as high-affinity ligands of the C-terminal Per-ARNT-Sim domain from the Hypoxia-inducible factor 3α.
Sci Rep
; 5: 12698, 2015 Aug 03.
Artigo
Inglês
| MEDLINE | ID: mdl-26237540
19.
Discovery of Schaeffer's acid analogues as lead structures of mycobacterium tuberculosis typeâ II dehydroquinase using a rational drug design approach.
ChemMedChem
; 8(1): 54-8, 2013 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-23169689
20.
Chimeric glycosyltransferases for the generation of hybrid glycopeptides.
Chem Biol
; 16(6): 676-85, 2009 Jun 26.
Artigo
Inglês
| MEDLINE | ID: mdl-19549605