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1.
Neurology ; 42(5): 1015-9, 1992 May.
Artigo em Inglês | MEDLINE | ID: mdl-1579224

RESUMO

A family had a disorder characterized by (1) a pattern suggestive of autosomal dominant inheritance, (2) recurrent attacks of focal brain deficits starting in mid adulthood and often leading to severe motor disability with pseudobulbar palsy and dementia of the subcortical type, and (3) neuroimaging evidence of leukoencephalopathy and well-circumscribed lesions consistent with small deep infarcts. Some affected members were clinically asymptomatic but had MRI signs of leukoencephalopathy. Extensive investigations failed to uncover a previously described recognizable genetic disorder.


Assuntos
Isquemia Encefálica/genética , Encéfalo/patologia , Demência/genética , Adulto , Idoso , Isquemia Encefálica/patologia , Demência/patologia , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Linhagem
2.
J Neuroradiol ; 24(2): 116-25, 1997 Aug.
Artigo em Francês | MEDLINE | ID: mdl-9324513

RESUMO

Stereotactic methodology developed at Sainte-Anne Hospital Center from 1947 is based on the application of a simple spatial geometry-the Talairach Ac-Pc reference system-to the cranial volume and the identification of any anatomical structure or brain lesion within this volume. Now upgraded with modern imaging techniques, this methodology is the ground for multiple applications in functional as well as lesional neurosurgery and is now a a part of the daily neurosurgical practice at Sainte-Anne Hospital. Stereotactic procedures include three steps: first, the identification of one or several target-volumes through stereotactic imaging acquisition: CT, MRI and conventional stereoscopic angiography; second, the image treatment on a dedicated workstation for stereotactic coordinates determination and surgical planning; third, the surgical procedure itself and its control. The most frequent applications for stereotactic methodology are: image-guided stereotactic biopsies of brain tumors, in order to obtain tissue pathological diagnosis and spatial configuration; linac-based radiosurgery of arterio-venous malformations and tumors with high energy collimated beams converging towards a simple or complex target volume; surgery for partial drug-resistant epilepsy including depth electrode implantation for stereo-electroencephalography and epileptogenic cortex resection; stereotactic image-guided resection of superficial or deep-seated tumors or vascular malformation; Rhenium 186 intracavitary irradiation of cystic tumors such as craniopharyngiomas.


Assuntos
Encéfalo/cirurgia , Técnicas Estereotáxicas , Biópsia , Braquiterapia/métodos , Encéfalo/anatomia & histologia , Encéfalo/diagnóstico por imagem , Encefalopatias/cirurgia , Neoplasias Encefálicas/patologia , Neoplasias Encefálicas/radioterapia , Neoplasias Encefálicas/cirurgia , Angiografia Cerebral , Sistemas Computacionais , Craniofaringioma/radioterapia , Resistência a Medicamentos , Eletrodos Implantados , Eletroencefalografia/instrumentação , Epilepsias Parciais/tratamento farmacológico , Epilepsias Parciais/cirurgia , Humanos , Processamento de Imagem Assistida por Computador , Sistemas de Informação , Malformações Arteriovenosas Intracranianas/cirurgia , Imageamento por Ressonância Magnética , Planejamento de Assistência ao Paciente , Radioisótopos/uso terapêutico , Compostos Radiofarmacêuticos/uso terapêutico , Radiocirurgia , Rênio/uso terapêutico , Tomografia Computadorizada por Raios X
3.
J Neuroradiol ; 23(1): 6-18, 1996 Jun.
Artigo em Francês | MEDLINE | ID: mdl-8767913

RESUMO

INTRODUCTION: The identification of the central region--i.e. the central sulcus, the pre- and post-central gyri, the paracentral lobule--on MRI and angiographic images may be necessary prior to stereotactic procedures such as biopsies or resection of centrally located tumors, depth electrode recordings for presurgical evaluation of drug-resistant epilepsies, or radiosurgery of arteriovenous malformations. Stereotactic methods, such as the Talairach's proportional grid based on the bicommissural system, demonstrated the statistical position of the central sulcus according to the Ac-Pc, Vac and Vpc baselines. However, the course and the spatial position of this sulcus have remarkable individual differences that sometimes make the sulcus difficult to identify on serial sagittal MRI or lateral angiographic images. In order to facilitate this identification, the authors propose a new oblique baseline, the rolandic (R) line. MATERIAL AND METHODS: The stereotactic MRI and angiography of 22 patients were reviewed for this study. Eleven of these patients had stereotactic biopsies for a low-grade tumor located in the central region, while eleven others had multiple intracerebral electrodes implantation and depth EEG recording (SEEG: stereoelectroencephalography) in the presurgical evaluation of drug-resistant partial epilepsy, prior to epileptogenic cortex resection. The Ac-Pc, Vac, Vpc baselines and segments of the central sulcus were drawn from the mid-sagittal and lateral T1-weighted MRI images and reported on an individual graph. Surface and deep margins as well as axis of the central sulcus were also reported along with corpus callosum baselines as defined by Olivier et al.: horizontal plane, anterior and posterior callosal planes. The rolandic line was then traced from the graph:it joined the intersection point between the anterior callosal plane and an orthogonal line passing through the floor of the temporal fossa, and the intersection point between posterior callosal plane and an orthogonal line passing through the top of the hemisphere. The rolandic line was then superimposed on any sagittal MRI image or lateral stereotactic angiographic film. Finally, the spatial position of electrode contracts through which electrical stimulations elicited motor and/or sensory responses, either from central electrode implanted for motor fibers identification prior to stereotactic biopsies or from SEEG electrodes implanted for epileptogenic zone identification and cortical mapping, was reported on the individual graph. Angular and linear measurements were taken from the graph, between the rolandic line, the central sulcus axis, the Ac-Pc and callosal baselines, and the central sulcus limits (top, bottom, anterior and posterior margins). RESULTS: Graph measurements indicated that the rolandic line was significantly closer to the inferior part of the central sulcus than to its superior part (average distance between the line and the inferior point of the sulcus: 1.86 +/- 1.87 mm; average distance between the line and the superior point of the sulcus: 4.5 +/- 2.3 mm; p < 0.001-t test); similarly, the rolandic line was closer to the deep margin of the sulcus rather than to its superficial border (average distance between the line and the most anterior point of the sulcus: 11.43 +/- 3.16 mm; average distance between the line and the most posterior point of the sulcus: 7.95 +/- 4.14 mm; p < 0.01-t test). In 90% of the cases, the rolandic line followed the deep or middle part of the sulcus, with an average angle of 4.18 degrees +/- 2.53 degrees between the line and the sulcus axis. The spatial position of the electrode contacts that elicited motor/or sensory responses to stimulations correlated topographically well in all cases with the position of the motor and sensory fibers defined according to the central sulcus, baselines and reference to stereotactic atlases. (ABSTRACT TRUNCATED)


Assuntos
Lobo Frontal/anatomia & histologia , Imageamento por Ressonância Magnética , Lobo Parietal/anatomia & histologia , Adolescente , Adulto , Biópsia , Neoplasias Encefálicas/patologia , Angiografia Cerebral , Criança , Pré-Escolar , Corpo Caloso/anatomia & histologia , Corpo Caloso/fisiologia , Eletrodos Implantados , Eletroencefalografia/instrumentação , Epilepsia/cirurgia , Feminino , Lobo Frontal/fisiologia , Humanos , Malformações Arteriovenosas Intracranianas/cirurgia , Masculino , Pessoa de Meia-Idade , Córtex Motor/anatomia & histologia , Córtex Motor/fisiologia , Lobo Parietal/fisiologia , Radiocirurgia , Reprodutibilidade dos Testes , Córtex Somatossensorial/anatomia & histologia , Córtex Somatossensorial/fisiologia , Técnicas Estereotáxicas
4.
Artigo em Francês | MEDLINE | ID: mdl-1791292

RESUMO

It has never been formally established whether eclampsia can come on more than 48 hours after delivery. We report a case of a patient who had convulsions together with transitory raised blood pressure coming on 14 days after her delivery. MRI was carried out 24 hours after the attack and showed pathological sub-cortical images and there was a hyper signal at T2. This is now a well known feature and has been described in the course of typical eclampsia fits. On the other hand MRI is able to eliminate a certain number of differential diagnoses such as cerebral thrombophlebitis, cerebral vascular accidents and tumours. A cerebral blood flow study and a trans-cranial Doppler flow study showed (as far as we know for the first time) a lessening in perfusion and in speed of flow giving rise to lowered blood circulation in that part of the brain and suggestive of vascular spasm. This observation makes it very likely that eclamptic crises can occur two weeks after delivery and favours a vascular spasm being the origin of these crises.


Assuntos
Isquemia Encefálica/diagnóstico , Eclampsia/diagnóstico , Hipertensão/diagnóstico , Transtornos Puerperais/diagnóstico , Adulto , Isquemia Encefálica/etiologia , Angiografia Cerebral/normas , Circulação Cerebrovascular , Eclampsia/complicações , Eclampsia/patologia , Feminino , Humanos , Hipertensão/etiologia , Imageamento por Ressonância Magnética/normas , Gravidez , Transtornos Puerperais/complicações , Transtornos Puerperais/patologia , Ultrassonografia/normas
6.
Sem Hop ; 60(13): 937-43, 1984 Mar 22.
Artigo em Francês | MEDLINE | ID: mdl-6326278

RESUMO

The search for an organic etiology in psychiatric conditions is greatly facilitated by modern radiological techniques. The most frequent etiologies demonstrated in the department of Radiology at the Sainte Anne Hospital were tumors, dementias, vascular disease and trauma with its attendant pathology.


Assuntos
Transtornos Neurocognitivos/etiologia , Adulto , Idoso , Encefalopatias/diagnóstico por imagem , Neoplasias Encefálicas/diagnóstico por imagem , Transtornos Cerebrovasculares/diagnóstico por imagem , Demência/diagnóstico por imagem , Diagnóstico Diferencial , Encefalite/diagnóstico por imagem , Feminino , Hematoma Subdural/diagnóstico por imagem , Humanos , Masculino , Pessoa de Meia-Idade , Radiografia
7.
Neuroradiology ; 27(6): 588-92, 1985.
Artigo em Inglês | MEDLINE | ID: mdl-4080156

RESUMO

The authors describe the epidemiology and the physiopathological aspects of ischemic strokes in patients with a history of oestroprogestogen use. They then study their main radiological correlates: arterial infarcts at CT scan and angiographic non-specific lesions which can be included in the extremely wide framework of arteritis and, much more rarely, venous thrombophlebitis.


Assuntos
Isquemia Encefálica/induzido quimicamente , Infarto Cerebral/induzido quimicamente , Anticoncepcionais Orais Hormonais/efeitos adversos , Arterite/induzido quimicamente , Doenças das Artérias Carótidas/induzido quimicamente , Hemorragia Cerebral/induzido quimicamente , Feminino , Humanos , Embolia e Trombose Intracraniana/induzido quimicamente , Tromboflebite/induzido quimicamente , Tomografia Computadorizada por Raios X
8.
Clin Chem ; 42(6 Pt 1): 933-41, 1996 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-8665686

RESUMO

Three labeled-antibody immunoassays of free triiodothyronine (FT3) were studied in hyperthyroid patients, patients with nonthyroidal illness, and patients being treated with amiodarone; we also studied sera presenting known interferences (n for all groups = 465). The results were compared with those of a one-step labeled-analog assay. The precision of the two automated assays were similar to that of the manual assays. The three labeled-antibody FT3 assays demonstrated a satisfactory diagnostic performance for confirming hyperthyroidism and robustness to interference; nevertheless, two assays displayed unusual behavior in some patients with nonthyroidal illness, with chronic renal failure, or after amiodarone therapy.


Assuntos
Imunoensaio/métodos , Imunoensaio/estatística & dados numéricos , Tri-Iodotironina/sangue , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Amiodarona/uso terapêutico , Autoanálise/estatística & dados numéricos , Autoanticorpos/sangue , Humanos , Hipertireoidismo/sangue , Falência Renal Crônica/sangue , Pessoa de Meia-Idade , Controle de Qualidade , Valores de Referência , Sensibilidade e Especificidade , Tiroxina/imunologia , Tri-Iodotironina/imunologia
9.
Nouv Rev Fr Hematol ; 15(6): 657-666, 1975.
Artigo em Francês | MEDLINE | ID: mdl-133335

RESUMO

A radio-assay, using a lactoglobulin fraction of milk proteins as a folate binder and 125-I pteroyl glutamate as a competitor, has been studied in 130 cases. The results have been compared to those obtained with microbiological methods. A good correlation has been observed. The radio-assay allows the measurement of folate in the presence of agents inhibiting the bacterial growth (methotrexate, trimethoprime). It can be used for assay in the cerebro-spinal fluid. This method appears to be useful for clinical investigations.


Assuntos
Ácido Fólico/sangue , Ácido Fólico/análise , Ácido Fólico/líquido cefalorraquidiano , Humanos , Métodos , Radioimunoensaio
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