Zika-related adverse outcomes in a cohort of pregnant women with rash in Pernambuco, Brazil.

BACKGROUND: While Zika virus (ZIKV) is now widely recognized as a teratogen, the frequency and full spectrum of adverse outcomes of congenital ZIKV infection remains incompletely understood. METHODS: Participants in the MERG cohort of pregnant women with rash, recruited from the surveillance system from December/2015-June/2017. Exposure definition was based on a combination of longitudinal data from molecular, serologic (IgM and IgG3) and plaque reduction neutralization tests for ZIKV. Children were evaluated by a team of clinical specialists and by transfontanelle ultrasound and were classified as having microcephaly and/or other signs/symptoms consistent with congenital Zika syndrome (CZS). Risks of adverse outcomes were quantified according to the relative evidence of a ZIKV infection in pregnancy. FINDINGS: 376 women had confirmed and suspected exposure to ZIKV. Among evaluable children born to these mothers, 20% presented with an adverse outcome compatible with exposure to ZIKV during pregnancy. The absolute risk of microcephaly was 2.9% (11/376), of calcifications and/or ventriculomegaly was 7.2% (13/180), of additional neurologic alterations was 5.3% (13/245), of ophthalmologic abnormalities was 7% (15/214), and of dysphagia was 1.8% (4/226). Less than 1% of the children experienced abnormalities across all of the domains simultaneously. Interpretation: Although approximately one-fifth of children with confirmed and suspected exposure to ZIKV in pregnancy presented with at least one abnormality compatible with CZS, the manifestations presented more frequently in isolation than in combination. Due to the rare nature of some outcomes and the possibility of later manifestations, large scale individual participant data meta-analysis and the long-term evaluation of children are imperative to identify the full spectrum of this syndrome and to plan actions to reduce damages.

Survival analysis in non-congenital neurological disorders related to dengue, chikungunya and Zika virus infections in Northeast Brazil.

The Northeast of Brazil has experienced a triple epidemic, with the simultaneous circulation of dengue virus (DENV), chikungunya virus (CHIKV) and Zika virus (ZIKV), which may have contributed to the observed increase across this region of atypical forms of disease and deaths. In view of this fact, non-congenital neurological disorders related to arboviruses were compared with other etiologies, mortality and survival rates of patients admitted to referral neurology hospitals in Pernambuco State, Northeast Brazil, from 2015 to 2018. Blood and cerebrospinal fluid samples were collected and tested using molecular and serological assays. The arbovirus-exposed groups were compared with respect to epidemiological, clinical and neurologic characteristics by using the Pearson's chi-square test. For the survival analysis, the Kaplan-Meier and Hazard Ratio (HR) tests were used, with a 95% confidence interval (CI). Encephalitis and encephalomyelitis were more frequent in arboviruses, while myelitis predominated in the neurological disorders of other etiologies. Guillain-Barré Syndrome (GBS) was similarly distributed amongst the groups. Exposure to one of the arboviruses caused a six-fold increase in the risk of death (HR: 6.37; CI: 2.91 - 13.9). Amongst the arbovirus-exposed groups, infection (DENV/CHIKV) increased nine times the risk of death (HR: 9.07; CI: 3.67 - 22.4). The survival curve indicates that have been exposed to some arbovirus decreased the likelihood of survival compared to those with other etiologies (Log-Rank: p<0.001). Within this scenario, neurologic manifestations of DENV, CHIKV and ZIKV have the potential to increase mortality and decrease survival, and concomitant infection (DENV/CHIKV) is an aggravating factor in reducing the likelihood of survival when compared to monoinfections.

The first hundred days of COVID-19 in Pernambuco State, Brazil: epidemiology in historical context. / Cem dias de COVID-19 em Pernambuco, Brasil: a epidemiologia em contexto histórico.

The timeline of the COVID-19 pandemic began on December 31, 2019, in China, with SARS-CoV-2 identified as the etiological agent. This article aims to describe the COVID-19 epidemic's spatial and temporal dynamics in the first hundred days in the State of Pernambuco, Brazil. We present the evolution in cases and deaths according to epidemiological weeks. We analyzed the series of accumulated daily confirmed COVID-19 cases, with projections for the subsequent 15 days, using the JoinPoint app. This software allows identifying turning points, testing their statistical significance. We also analyze the trend in the spread of COVID-19 to the interior of the state, considering the percent distribution of cases in the state capital, Recife, municipalities in Greater Metropolitan Recife, and the state's interior, by sets of three weeks, constructing thematic maps. The first hundred days of the COVID-19 epidemic resulted in 52,213 cases and 4,235 deaths from March 12, or epidemiological week 11, until June 20, 2020 (epidemiological week 25). The peak in the epidemic curve occurred in epidemiological week 21 (May 23), followed by deceleration in the number of cases. We initially detected the spread of cases from the city center to the periphery of the state capital and Metropolitan Area, followed by rapid spread to the state's interior. There was a decrease in the mean daily growth starting in April, but with an average threshold of more than 6,000 weekly cases of COVID-19. At the end of the period, the state's case series indicates the persistence of SARS-CoV-2 circulation and community transmission. Finally, paraphrasing Gabriel Garcia Marques in One Hundred Years of Solitude, we ask whether we are facing "a pause in the storm or a sign of redoubled rain".

A pandemia de COVID-19 iniciou sua linha do tempo em 31 de dezembro de 2019 na China e o SARS-CoV-2 identificado como agente etiológico. O objetivo deste manuscrito é descrever a dinâmica espacial e temporal da epidemia de COVID-19 nos primeiros cem dias, no Estado de Pernambuco, Brasil. Apresentamos a evolução de casos e óbitos segundo semana epidemiológica. Realizamos a análise da série do acumulado diário de casos da COVID-19 confirmados, com projeções para os 15 dias subsequentes, utilizando o aplicativo JoinPoint. Esse programa possibilita identificar pontos de inflexão testando sua significância estatística. Analisamos também a tendência de interiorização da COVID-19 no estado, considerando a distribuição percentual de casos ocorridos no Recife, municípios da Região Metropolitana de Recife e do interior, por conjuntos de três semanas, com construção de mapas temáticos. Os 100 dias da epidemia de COVID-19 resultaram em 52.213 casos e 4.235 óbitos entre 12 de março, correspondendo se 11, até 20 de junho de 2020 (semana epidemiológica 25). O pico da curva epidêmica ocorreu na semana epidemiológica 21 (23 de maio), seguido por desaceleração do número de casos. Detectou-se, inicialmente, a periferização dos casos na capital e região metropolitana, seguida por rápida disseminação para o interior do estado. Houve redução das taxas de crescimento médio diário a partir de abril, mas com patamar de mais de 6.000 casos semanais de COVID-19, em média. Ao final do período, a série de casos do estado indica persistência da circulação e transmissão comunitária do SARS-CoV-2. Finalmente, questiona-se parafraseando Garcia Marques em Cem Anos de Solidão, se estaríamos diante de "uma estiagem ou prenúncio de recrudescimento".

La pandemia de COVID-19 inicia su línea del tiempo el 31 de dicembre de 2019 en China y el SARS-CoV-2 identificado como agente etiológico. El objetivo de este trabajo original es describir la dinámica espacial y temporal de la epidemia de COVID-19 en los primeros cien días de epidemia, en el estado de Pernambuco, Brasil. Presentamos la evolución de casos y óbitos según las semanas epidemiológicas. Realizamos el análisis de la serie del acumulado diario de casos de COVID-19 confirmados, con proyecciones para los 15 días subsiguientes, utilizándose la aplicación JoinPoint. Este programa posibilita identificar puntos de inflexión, probando su significancia estadística. Analizamos también la tendencia de interiorización de la COVID-19 en el estado, considerándose la distribución porcentual de casos ocurridos en Recife, municipios de la Región Metropolitana de Recife y del interior, por conjuntos de tres semanas, con unas construcciones de mapas temáticos. Los cien días de la epidemia de COVID-19 resultaron en 52.213 casos y 4.235 óbitos entre el 12 de marzo, correspondiendo a la semana epidemiológica 11, hasta el 20 de juno de 2020 (semana epidemiológica 25). El pico de la curva epidémica ocurrió en la semana epidemiológica 21 (23 de mayo), seguido de una desaceleración en el número de casos. Se detectó, inicialmente, la periferización de los casos en la capital y región metropolitana, seguido por la rápida diseminación hacia el interior del estado. Hubo una reducción de las tasas de crecimiento medio diario a partir de abril, pero con un nivel de más de 6.000 casos semanales de COVID-19 de media. Al final del período la serie de casos del estado indica la persistencia de la circulación y transmisión comunitaria del SARS-CoV-2. Finalmente, se cuestiona, parafraseando a García Márquez en Cien Años de Soledad, si estamos ante "un periodo de remisión o la antesala de un recrudecimiento".

Outbreak of Guillain-Barré syndrome possibly related to prior Zika virus infection, Metropolitan Region of Recife, Pernambuco, Brazil, 2015. / Surto de síndrome de Guillain-Barré possivelmente relacionado à infecção prévia pelo vírus Zika, Região Metropolitana do Recife, Pernambuco, Brasil, 2015.

OBJETIVO: to investigate the occurrence of GBS in the Metropolitan Region of Recife, PE, Brazil, 2015. METHODS: this was a descriptive study using data from the Hospital Information System, National Pharmaceutical Services Management System and interviews; GBS cases were classified according to Brighton criteria and prior infection according to laboratory and clinical criteria. RESULTS: in 2015, the number of GBS hospitalizations had a threefold increase in comparison to 2014. We investigated 44 confirmed or probable GBS cases, of which 18 had symptoms of Zika infection up to 35 days before the occurrence of GBS, mainly rash; one case was laboratory-confirmed for Zika virus infection and one death was registered. CONCLUSION: the findings reinforce a possible relationship between GBS and Zika infection, given the absence of increased GBS occurrence in previous dengue epidemic years, absence of chikungunya transmission records, presence of clinical manifestations compatible with infection and a laboratory confirmation.

Saúde na Copa: The World's First Application of Participatory Surveillance for a Mass Gathering at FIFA World Cup 2014, Brazil.

BACKGROUND: The 2005 International Health Regulations (IHRs) established parameters for event assessments and notifications that may constitute public health emergencies of international concern. These requirements and parameters opened up space for the use of nonofficial mechanisms (such as websites, blogs, and social networks) and technological improvements of communication that can streamline the detection, monitoring, and response to health problems, and thus reduce damage caused by these problems. Specifically, the revised IHR created space for participatory surveillance to function, in addition to the traditional surveillance mechanisms of detection, monitoring, and response. Participatory surveillance is based on crowdsourcing methods that collect information from society and then return the collective knowledge gained from that information back to society. The spread of digital social networks and wiki-style knowledge platforms has created a very favorable environment for this model of production and social control of information. OBJECTIVE: The aim of this study was to describe the use of a participatory surveillance app, Healthy Cup, for the early detection of acute disease outbreaks during the Fédération Internationale de Football Association (FIFA) World Cup 2014. Our focus was on three specific syndromes (respiratory, diarrheal, and rash) related to six diseases that were considered important in a mass gathering context (influenza, measles, rubella, cholera, acute diarrhea, and dengue fever). METHODS: From May 12 to July 13, 2014, users from anywhere in the world were able to download the Healthy Cup app and record their health condition, reporting whether they were good, very good, ill, or very ill. For users that reported being ill or very ill, a screen with a list of 10 symptoms was displayed. Participatory surveillance allows for the real-time identification of aggregates of symptoms that indicate possible cases of infectious diseases. RESULTS: From May 12 through July 13, 2014, there were 9434 downloads of the Healthy Cup app and 7155 (75.84%) registered users. Among the registered users, 4706 (4706/7155, 65.77%) were active users who posted a total of 47,879 times during the study period. The maximum number of users that signed up in one day occurred on May 30, 2014, the day that the app was officially launched by the Minister of Health during a press conference. During this event, the Minister of Health announced the special government program Health in the World Cup on national television media. On that date, 3633 logins were recorded, which accounted for more than half of all sign-ups across the entire duration of the study (50.78%, 3633/7155). CONCLUSIONS: Participatory surveillance through community engagement is an innovative way to conduct epidemiological surveillance. Compared to traditional epidemiological surveillance, advantages include lower costs of data acquisition, timeliness of information collected and shared, platform scalability, and capacity for integration between the population being served and public health services.

Digital disease detection and participatory surveillance: overview and perspectives for Brazil.

This study aimed to describe the digital disease detection and participatory surveillance in different countries. The systems or platforms consolidated in the scientific field were analyzed by describing the strategy, type of data source, main objectives, and manner of interaction with users. Eleven systems or platforms, developed from 1996 to 2016, were analyzed. There was a higher frequency of data mining on the web and active crowdsourcing as well as a trend in the use of mobile applications. It is important to provoke debate in the academia and health services for the evolution of methods and insights into participatory surveillance in the digital age.

[Outbreak of foodborne disease at a mass event of indigenous peoples in Cuiaba, Mato Grosso, Brazil, in 2013]. / Surto de doença transmitida por alimento em evento de massa de populações indígenas em Cuiabá, Mato Grosso, Brasil, no ano de 2013.

OBJECTIVE: to report the experience of investigating the outbreak of acute diarrhoea (AD) at the XII Indigenous Games in Cuiabá, Mato Grosso, Brazil, 2013. METHODS: data were collected from the Advanced Medical Post's service records of the AD cases, which were defined as 'individual Games participant referring episode of diarrhoea and/or vomiting'; AD attack rates, relative frequencies and measures of the central tendency of sociodemographic and clinical variables, sanitary inspections and results of bromatological samples were calculated. RESULTS: 384 (37%) cases met the definition of AD; the epidemic peaks of the outbreak occurred on the 4th and 7th day of the event and the disease attack rate was 33.5%; sanitary inspection showed evidence of food contamination by coagulase-negative Staphylococci, Bacillus cereus and heat resistant coliforms. CONCLUSION: there an outbreak of AD caused by food contamination.

Microcephaly in Pernambuco State, Brazil: epidemiological characteristics and evaluation of the diagnostic accuracy of cutoff points for reporting suspected cases. / Microcefalia no Estado de Pernambuco, Brasil: características epidemiológicas e avaliação da acurácia diagnóstica dos pontos de corte adotados para notificação de caso.

The increase in the number of reported cases of microcephaly in Pernambuco State, and Northeast Brazil, characterized an epidemic that led the Brazilian Ministry of Health to declare a national public health emergency. The Brazilian Ministry of Health initially defined suspected cases as newborns with gestational age (GA) ≥ 37 weeks and head circumference (HC) ≤ 33cm, but in December 2015 this cutoff was lowered to 32cm. The current study aimed to estimate the accuracy, sensitivity, and specificity of different cutoff points for HC, using ROC curves, with the Fenton and Intergrowth (2014) curves as the gold standard. The study described cases reported in Pernambuco from August 8 to November 28, 2015, according to sex and GA categories. The Fenton and Intergrowth methods provide HC growth curves according to GA and sex, and microcephaly is defined as a newborn with HC below the 3rd percentile in these distributions. Of the 684 reported cases, 599 were term or post-term neonates. For these, the analyses with ROC curves show that according to the Fenton criterion the cutoff point with the largest area under the ROC curve, with sensitivity greater than specificity, is 32cm for both sexes. Using the Intergrowth method and following the same criteria, the cutoff points are 32cm and 31.5cm for males and females, respectively. The cutoff point identified by the Fenton method (32cm) coincided with the Brazilian Ministry of Health recommendation. Adopting Intergrowth as the standard, the choice would be 32cm for males and 31.5cm for females. The study identified the need to conduct critical and on-going analyses to evaluate cutoff points, including other characteristics for microcephaly case definition.

Characteristics of the first cases of microcephaly possibly related to Zika virus reported in the Metropolitan Region of Recife, Pernambuco State, Brazil. / Características dos primeiros casos de microcefalia possivelmente relacionados ao vírus Zika notificados na Região Metropolitana de Recife, Pernambuco.

OBJECTIVE: to describe the first cases of microcephaly possibly related to Zika virus in live born babies reported in the Metropolitan Region of Recife, Pernambuco State, Brazil. METHODS: this was a descriptive case series study (cases reported between August 1st and October 31st 2015), using medical record data and data from a questionnaire answered by the mothers of the babies. RESULTS: 40 microcephaly cases were confirmed, distributed in eight municipalities within the Metropolitan Region, with Recife itself having the highest concentration of cases (n=12); median head circumference was 29 cm, median chest girth was 31 cm and median weight was 2,628 grams; 21/25 cases had brain calcification, ventriculomegaly or lissencephaly; 27 of the 40 mothers reported rash during pregnancy, 20 in the first trimester and 7 in the second trimester, as well as itching, headache, myalgia and absence of fever. CONCLUSION: the majority of the cases bore the characteristics of congenital infection; the clinical condition of the majority of mothers suggested Zika virus infection during pregnancy.

Cem dias de COVID-19 em Pernambuco, Brasil: a epidemiologia em contexto histórico / Cien días de COVID-19 en Pernambuco, Brasil: la epidemiología en contexto histórico / The first hundred days of COVID-19 in Pernambuco State, Brazil: epidemiology in historical context

Resumo: A pandemia de COVID-19 iniciou sua linha do tempo em 31 de dezembro de 2019 na China e o SARS-CoV-2 identificado como agente etiológico. O objetivo deste manuscrito é descrever a dinâmica espacial e temporal da epidemia de COVID-19 nos primeiros cem dias, no Estado de Pernambuco, Brasil. Apresentamos a evolução de casos e óbitos segundo semana epidemiológica. Realizamos a análise da série do acumulado diário de casos da COVID-19 confirmados, com projeções para os 15 dias subsequentes, utilizando o aplicativo JoinPoint. Esse programa possibilita identificar pontos de inflexão testando sua significância estatística. Analisamos também a tendência de interiorização da COVID-19 no estado, considerando a distribuição percentual de casos ocorridos no Recife, municípios da Região Metropolitana de Recife e do interior, por conjuntos de três semanas, com construção de mapas temáticos. Os 100 dias da epidemia de COVID-19 resultaram em 52.213 casos e 4.235 óbitos entre 12 de março, correspondendo se 11, até 20 de junho de 2020 (semana epidemiológica 25). O pico da curva epidêmica ocorreu na semana epidemiológica 21 (23 de maio), seguido por desaceleração do número de casos. Detectou-se, inicialmente, a periferização dos casos na capital e região metropolitana, seguida por rápida disseminação para o interior do estado. Houve redução das taxas de crescimento médio diário a partir de abril, mas com patamar de mais de 6.000 casos semanais de COVID-19, em média. Ao final do período, a série de casos do estado indica persistência da circulação e transmissão comunitária do SARS-CoV-2. Finalmente, questiona-se parafraseando Garcia Marques em Cem Anos de Solidão, se estaríamos diante de "uma estiagem ou prenúncio de recrudescimento".

Resumen: La pandemia de COVID-19 inicia su línea del tiempo el 31 de dicembre de 2019 en China y el SARS-CoV-2 identificado como agente etiológico. El objetivo de este trabajo original es describir la dinámica espacial y temporal de la epidemia de COVID-19 en los primeros cien días de epidemia, en el estado de Pernambuco, Brasil. Presentamos la evolución de casos y óbitos según las semanas epidemiológicas. Realizamos el análisis de la serie del acumulado diario de casos de COVID-19 confirmados, con proyecciones para los 15 días subsiguientes, utilizándose la aplicación JoinPoint. Este programa posibilita identificar puntos de inflexión, probando su significancia estadística. Analizamos también la tendencia de interiorización de la COVID-19 en el estado, considerándose la distribución porcentual de casos ocurridos en Recife, municipios de la Región Metropolitana de Recife y del interior, por conjuntos de tres semanas, con unas construcciones de mapas temáticos. Los cien días de la epidemia de COVID-19 resultaron en 52.213 casos y 4.235 óbitos entre el 12 de marzo, correspondiendo a la semana epidemiológica 11, hasta el 20 de juno de 2020 (semana epidemiológica 25). El pico de la curva epidémica ocurrió en la semana epidemiológica 21 (23 de mayo), seguido de una desaceleración en el número de casos. Se detectó, inicialmente, la periferización de los casos en la capital y región metropolitana, seguido por la rápida diseminación hacia el interior del estado. Hubo una reducción de las tasas de crecimiento medio diario a partir de abril, pero con un nivel de más de 6.000 casos semanales de COVID-19 de media. Al final del período la serie de casos del estado indica la persistencia de la circulación y transmisión comunitaria del SARS-CoV-2. Finalmente, se cuestiona, parafraseando a García Márquez en Cien Años de Soledad, si estamos ante "un periodo de remisión o la antesala de un recrudecimiento".

Abstract: The timeline of the COVID-19 pandemic began on December 31, 2019, in China, with SARS-CoV-2 identified as the etiological agent. This article aims to describe the COVID-19 epidemic's spatial and temporal dynamics in the first hundred days in the State of Pernambuco, Brazil. We present the evolution in cases and deaths according to epidemiological weeks. We analyzed the series of accumulated daily confirmed COVID-19 cases, with projections for the subsequent 15 days, using the JoinPoint app. This software allows identifying turning points, testing their statistical significance. We also analyze the trend in the spread of COVID-19 to the interior of the state, considering the percent distribution of cases in the state capital, Recife, municipalities in Greater Metropolitan Recife, and the state's interior, by sets of three weeks, constructing thematic maps. The first hundred days of the COVID-19 epidemic resulted in 52,213 cases and 4,235 deaths from March 12, or epidemiological week 11, until June 20, 2020 (epidemiological week 25). The peak in the epidemic curve occurred in epidemiological week 21 (May 23), followed by deceleration in the number of cases. We initially detected the spread of cases from the city center to the periphery of the state capital and Metropolitan Area, followed by rapid spread to the state's interior. There was a decrease in the mean daily growth starting in April, but with an average threshold of more than 6,000 weekly cases of COVID-19. At the end of the period, the state's case series indicates the persistence of SARS-CoV-2 circulation and community transmission. Finally, paraphrasing Gabriel Garcia Marques in One Hundred Years of Solitude, we ask whether we are facing "a pause in the storm or a sign of redoubled rain".

Surto de síndrome de Guillain-Barré possivelmente relacionado à infecção prévia pelo vírus Zika, Região Metropolitana do Recife, Pernambuco, Brasil, 2015 / Brote de síndrome de Guillain-Barré potencialmente relacionado con la infección anterior por el virus Zika, en la Región Metropolitana de Recife, Pernambuco, Brasil, 2015 / Outbreak of Guillain-Barré syndrome possibly related to prior Zika virus infection, Metropolitan Region of Recife, Pernambuco, Brazil, 2015

Objetivo: investigar a ocorrência da síndrome de Guillain-Barré (SGB) na Região Metropolitana do Recife, Brasil, 2015. Métodos: estudo descritivo com dados do Sistema de Informações Hospitalares, Sistema Nacional de Gestão da Assistência Farmacêutica e entrevistas; os casos de SGB foram classificados segundo os critérios de Brighton, e a infecção prévia, segundo critérios laboratoriais e clínicos. Resultados: em 2015, houve três vezes mais internações por SGB que em 2014; investigaram-se 44 casos confirmados ou prováveis de SGB, dos quais 18 apresentaram sintomas de infecção por Zika até 35 dias antes da ocorrência da SGB, principalmente exantema; houve um caso confirmado laboratorialmente para Zika e um óbito. Conclusão: os achados reforçam possível relação da SGB com infecção por Zika, por ausência de aumento da ocorrência da SGB em anos epidêmicos de dengue, ausência de registro de transmissão de chikungunya, presença de manifestações clínicas compatíveis com infecção por Zika e uma confirmação laboratorial.

Objetivo: investigar la ocurrencia de SGB en la Región Metropolitana de Recife, Brasil, 2015. Métodos: estudio descriptivo utilizando datos del Sistema de Información Hospitalaria, Sistema Nacional de Gestión de Atención Farmacéutica y entrevistas; los casos de SGB fueron clasificados de acuerdo con criterios de Brighton y la infección anterior segundo criterios laboratoriales y clínicos. Resultados: en 2015, hubo tres veces más internaciones por SGB que 2014; se investigaron 44 casos confirmados o probables de SGB, donde 18 tenían síntomas de infección por Zika hasta 35 días antes de la SGB, especialmente erupción; hubo una confirmación laboratorial de Zika y una muerte. Conclusión: los hallazgos refuerzan la posible relación de SGB con infección por Zika, frente la ausencia de aumento de la ocurrencia de SGB en años epidémicos de dengue, ausencia de registro de transmisión de chikungunya, presencia de manifestaciones clínicas compatibles con infección previa por Zika y una confirmación laboratorial.

Objetivo: to investigate the occurrence of GBS in the Metropolitan Region of Recife, PE, Brazil, 2015. Methods: this was a descriptive study using data from the Hospital Information System, National Pharmaceutical Services Management System and interviews; GBS cases were classified according to Brighton criteria and prior infection according to laboratory and clinical criteria. Results: in 2015, the number of GBS hospitalizations had a threefold increase in comparison to 2014. We investigated 44 confirmed or probable GBS cases, of which 18 had symptoms of Zika infection up to 35 days before the occurrence of GBS, mainly rash; one case was laboratory-confirmed for Zika virus infection and one death was registered. Conclusion: the findings reinforce a possible relationship between GBS and Zika infection, given the absence of increased GBS occurrence in previous dengue epidemic years, absence of chikungunya transmission records, presence of clinical manifestations compatible with infection and a laboratory confirmation.

Características dos primeiros casos de microcefalia possivelmente relacionados ao vírus Zika notificados na Região Metropolitana de Recife, Pernambuco / Características de los primeros casos de microcefalia, posiblemente relacionadas con el virus Zika reportados en la Región Metropolitana de Recife / Characteristics of the first cases of microcephaly possibly related to Zika virus reported in the Metropolitan Region of Recife, Pernambuco State, Brazil

OBJETIVO: descrever os primeiros casos de microcefalia possivelmente relacionados ao vírus Zika em nascidos vivos notificados na Região Metropolitana do Recife, Pernambuco, Brasil. MÉTODOS: estudo descritivo de tipo série de casos (notificados de 1º de agosto a 31 de outubro de 2015), com dados obtidos dos registros médicos e de questionário aplicado às mães. RESULTADOS: foram confirmados 40 casos com microcefalia, distribuídos em oito municípios da Região Metropolitana do Recife, com maior concentração no Recife (n=12); a mediana do perímetro cefálico foi de 29 cm, do perímetro torácico, 31 cm, e do peso, 2.628 gramas; 21/25 casos apresentaram calcificação cerebral, ventriculomegalia ou lisencefalia; entre as 40 mães, 27 referiram exantema na gestação, 20 no primeiro trimestre e sete no segundo, além de prurido, cefaleia, mialgia e ausência de febre. CONCLUSÃO: a maioria dos casos apresentou características de infecção congênita; a maioria das mães apresentou quadro sugestivo de infecção pelo vírus Zika na gestação.

OBJETIVO: describir los primeros casos de microcefalia en nacidos vivos reportados al Departamento de Salud del Estado de Pernambuco, en la región metropolitana de Recife, Pernambuco, 2015. MÉTODOS: estudio epidemiológico descriptivo de serie de casos (reportados de 1 de agosto a 31 de octubre de 2015), con datos obtenidos de registros médicos y cuestionarios aplicados a las madres. RESULTADOS: 40 casos fueron confirmados con microcefalia, en ocho municipios de la región metropolitana de Recife, con mayor concentración de casos en Recife (n=12); la circunferencia media de la cabeza fue 29 cm, perímetro torácico 31 cm y peso 2.628 gramos; exámenes revelaron que 21/25 casos mostraron calcificación, dilatación ventricular o lisencefalia; de las 40 madres, 27 (68%) informan exantema durante la gestación, 20 (74%) en el primer trimestre y siete (26%) en la segunda, además de prurito, dolor de cabeza, mialgia y ausencia de fiebre. CONCLUSIÓN: la mayoría de los casos presenta características de infección congénita; la mayoría de las madres mostró características que sugieren infección por el virus Zika en el embarazo.

OBJECTIVE: to describe the first cases of microcephaly possibly related to Zika virus in live born babies reported in the Metropolitan Region of Recife, Pernambuco State, Brazil. METHODS: this was a descriptive case series study (cases reported between August 1st and October 31st 2015), using medical record data and data from a questionnaire answered by the mothers of the babies. RESULTS: 40 microcephaly cases were confirmed, distributed in eight municipalities within the Metropolitan Region, with Recife itself having the highest concentration of cases (n=12); median head circumference was 29 cm, median chest girth was 31 cm and median weight was 2,628 grams; 21/25 cases had brain calcification, ventriculomegaly or lissencephaly; 27 of the 40 mothers reported rash during pregnancy, 20 in the first trimester and 7 in the second trimester, as well as itching, headache, myalgia and absence of fever. CONCLUSION: the majority of the cases bore the characteristics of congenital infection; the clinical condition of the majority of mothers suggested Zika virus infection during pregnancy.

Avaliação do Sistema de Informações sobre Nascidos Vivos. Brasil, 2006 a 2010 / Evaluación del Sistema de Información de Nacidos Vivos. Brasil, 2006 a 2010 / Evaluation of the National Information System on Live Births in Brazil, 2006-2010

OBJETIVO: avaliar atributos e utilidade do Sistema de Informações sobre Nascidos Vivos (Sinasc), Brasil, 2006-2010. METÓDOS: avaliação baseada nas diretrizes do Guia de Avaliação dos Sistemas de Vigilância de Saúde Pública do Centers for Disease Control and Prevention/USA. RESULTADOS: das 23 variáveis avaliadas, 21 apresentaram completude superior a 90,0%; o percentual de completude de variáveis preenchidas em partos hospitalares foi 97,9%; não houve diferença entre as proporções de nascimentos segundo macrorregiões e sexo, na comparação com os dados do Censo Demográfico 2010. Foram recebidos em tempo oportuno 82,6% do volume de dados, em 2010; a razão entre nascidos vivos informados e estimados foi de 89,4% em 2006 e de 97,4% em 2010; dados do Sinasc eram utilizados em 22 indicadores de monitoramento. CONCLUSÃO: os atributos avaliados e a utilidade do Sinasc ratificam a qualidade e a importância das informações geradas pelo sistema para subsidiar políticas públicas de saúde materno-infantil.

OBJETIVO: evaluar los atributos y utilidad del Sistema de Información de Nacidos Vivos (SINASC), Brasil,2006-2010. MÉTODOS: esta evaluación se basó en las directrices de la Guía para Evaluación de Sistemas de Vigilancia de Salud Pública del Center for Disease Control and Prevention/USA. RESULTADOS: de las 23 variables evaluadas, 21 mostraron completitud superior al 90%; el porcentaje de completitud de las variables llenadas en los partos hospitalarios fue de 97,9%; no hubo diferencias en las proporciones de nacimientos de mujeres y hombres, cuando comparados con el censo de 2010; se recibió a tiempo 82,6% del volumen de datos en 2010; la proporción de nacidos vivos informados y estimados fue 89,4% en 2006 y 97,4% en 2010; se utilizó para la construcción de 22 indicadores de monitoreo de salud datos del Sinasc. CONCLUSIÓN: los atributos evaluados y la utilidad del Sinasc destacaron la calidad e importancia de la información generada por el sistema para subsidiar políticas públicas de salud materno-infantil.

OBJECTIVE: to analyze attributes and usefulness of the Live Birth Information System (Sinasc), Brazil, 2006-2010. METHODS: this evaluation was based on the Centers for Disease Control and Prevention Guidelines for Evaluating Public Health Surveillance Systems. RESULTS: 21 of the 23 variables analyzed showed completeness above 90.0%. 97.9% of hospital birth variables had complete data; no differences in the proportion of births were found with regard to macroregion and sex when compared to the 2010 census; 82.6% of data was received on time in 2010; the ratio between reported and estimated live births was 89.4% in 2006 and 97.4% in 2010; this system was used to build 22 health monitoring indicators. CONCLUSION: the aspects evaluated and usefulness of Sinasc confirm the quality and importance of the information it provides in serving as input for public policies on maternal and child health.

New variant of Creutzfeldt-Jakob (vCJD) disease and other human prion diseases under epidemiological surveillance in Brazil.

To increase the timeliness of detection of human cases of the new variant of Creutzfeldt-Jakob disease (vCJD) and to reduce the risk of transmission, the Brazilian Ministry of Health has established and standardized rules and control measures. These include the definition of criteria for suspect cases, reporting, monitoring, and control measures for illness prevention and transmission. Guidelines to be used by the team of health care staff were published and distributed to health workers. A detailed proposal for a simplified system of surveillance for prion diseases was developed and mandatory reporting introduced. Additional effort is necessary to increase vCJD case detection, thus making it necessary to establish a partnership with health care services for best identification of suspected cases and dissemination of information to all involved in the service dealing with vCJD investigation.

Com o objetivo de detectar de maneira oportuna casos humanos da nova variante da Doença de Creutzfeldt-Jakob (vDCJ) e de reduzir o risco de transmissão da doença, o Ministério da Saúde (MS) vem estabelecendo e padronizando normas e medidas de controle. Estas incluem critérios de suspeita diagnóstica, notificação, monitoramento e medidas de prevenção da doença e seus mecanismos de transmissão. Procedimentos a serem adotados pela área de assistência à saúde também foram produzidos e divulgados. Desenvolveu-se uma proposta detalhada do Sistema Simplificado de Vigilância Epidemiológica das Doenças Priônicas, estabelecendo a compulsoriedade de sua notificação. Muito esforço ainda será necessário para efetiva e rotineira captação da ocorrência de um caso suspeito de vDCJ, por isso faz-se necessário o estabelecimento de uma parceria com os profissionais da assistência por serem estes os que têm a capacidade de identificar suspeitos e remeter a informação a todos aqueles que devem conhecê-la.