Detalhe da pesquisa
1.
Development and Characterization of Selective FAK Inhibitors and PROTACs with In Vivo Activity.
Chembiochem
; 24(19): e202300141, 2023 10 04.
Artigo
Inglês
| MEDLINE | ID: mdl-37088717
2.
Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo.
Nat Chem Biol
; 17(9): 954-963, 2021 09.
Artigo
Inglês
| MEDLINE | ID: mdl-33972797
3.
Identification of a potent and selective covalent Pin1 inhibitor.
Nat Chem Biol
; 16(9): 979-987, 2020 09.
Artigo
Inglês
| MEDLINE | ID: mdl-32483379
4.
SAICAR induces protein kinase activity of PKM2 that is necessary for sustained proliferative signaling of cancer cells.
Mol Cell
; 53(5): 700-9, 2014 Mar 06.
Artigo
Inglês
| MEDLINE | ID: mdl-24606918
5.
Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation.
Nat Chem Biol
; 14(2): 163-170, 2018 02.
Artigo
Inglês
| MEDLINE | ID: mdl-29251720
6.
A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification.
J Am Chem Soc
; 141(1): 191-203, 2019 01 09.
Artigo
Inglês
| MEDLINE | ID: mdl-30518210
7.
Synthesis and structure activity relationships of a series of 4-amino-1H-pyrazoles as covalent inhibitors of CDK14.
Bioorg Med Chem Lett
; 29(15): 1985-1993, 2019 08 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31175010
8.
Characterization of a highly selective inhibitor of the Aurora kinases.
Bioorg Med Chem Lett
; 27(18): 4405-4408, 2017 09 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28818446
9.
Toward discovery of mutant EGFR inhibitors; Design, synthesis and in vitro biological evaluation of potent 4-arylamino-6-ureido and thioureido-quinazoline derivatives.
Bioorg Med Chem
; 24(16): 3501-12, 2016 08 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27288180
10.
Development and Characterization of a Wee1 Kinase Degrader.
Cell Chem Biol
; 27(1): 57-65.e9, 2020 01 16.
Artigo
Inglês
| MEDLINE | ID: mdl-31735695
11.
Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity.
Cell Chem Biol
; 26(6): 804-817.e12, 2019 06 20.
Artigo
Inglês
| MEDLINE | ID: mdl-30930164
12.
Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells.
Nat Commun
; 9(1): 3069, 2018 08 09.
Artigo
Inglês
| MEDLINE | ID: mdl-30093655
13.
A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader.
Cell Chem Biol
; 25(1): 88-99.e6, 2018 01 18.
Artigo
Inglês
| MEDLINE | ID: mdl-29129717