Detalhe da pesquisa
1.
CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory.
Proc Natl Acad Sci U S A
; 119(7)2022 02 15.
Artigo
Inglês
| MEDLINE | ID: mdl-35140181
2.
A unique hinge binder of extremely selective aminopyridine-based Mps1 (TTK) kinase inhibitors with cellular activity.
Bioorg Med Chem
; 23(9): 2247-60, 2015 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-25801152
3.
Preclinical antitumor activity of S-222611, an oral reversible tyrosine kinase inhibitor of epidermal growth factor receptor and human epidermal growth factor receptor 2.
Cancer Sci
; 105(8): 1040-8, 2014 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-24837299
4.
Discovery of novel 5-alkynyl-4-anilinopyrimidines as potent, orally active dual inhibitors of EGFR and Her-2 tyrosine kinases.
Bioorg Med Chem Lett
; 22(1): 456-60, 2012 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22101132
5.
Immunogenicity and protective efficacy of SARS-CoV-2 recombinant S-protein vaccine S-268019-b in cynomolgus monkeys.
Vaccine
; 40(31): 4231-4241, 2022 07 29.
Artigo
Inglês
| MEDLINE | ID: mdl-35691872
6.
Immune response and protective efficacy of the SARS-CoV-2 recombinant spike protein vaccine S-268019-b in mice.
Sci Rep
; 12(1): 20861, 2022 12 02.
Artigo
Inglês
| MEDLINE | ID: mdl-36460696
7.
Synthesis and evaluation of novel pyrimidine-based dual EGFR/Her-2 inhibitors.
Bioorg Med Chem Lett
; 21(6): 1601-6, 2011 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21334203
8.
Destruxin E decreases Beta-amyloid generation by reducing colocalization of beta-amyloid-cleaving enzyme 1 and beta-amyloid protein precursor.
Neurodegener Dis
; 6(5-6): 230-9, 2009.
Artigo
Inglês
| MEDLINE | ID: mdl-19738368
9.
Author Correction: Immune response and protective efficacy of the SARS-CoV-2 recombinant spike protein vaccine S-268019-b in mice.
Sci Rep
; 14(1): 2599, 2024 Jan 31.
Artigo
Inglês
| MEDLINE | ID: mdl-38297027
10.
Development of a new knock-in mouse model and evaluation of pharmacological activities of lusutrombopag, a novel, nonpeptidyl small-molecule agonist of the human thrombopoietin receptor c-Mpl.
Exp Hematol
; 59: 30-39.e2, 2018 03.
Artigo
Inglês
| MEDLINE | ID: mdl-29274361
11.
Wnt5a promotes cancer cell invasion and proliferation by receptor-mediated endocytosis-dependent and -independent mechanisms, respectively.
Sci Rep
; 5: 8042, 2015 Jan 27.
Artigo
Inglês
| MEDLINE | ID: mdl-25622531
12.
Discovery of imidazo[1,2-b]pyridazine derivatives: selective and orally available Mps1 (TTK) kinase inhibitors exhibiting remarkable antiproliferative activity.
J Med Chem
; 58(4): 1760-75, 2015 Feb 26.
Artigo
Inglês
| MEDLINE | ID: mdl-25625617
13.
High-throughput miniaturized immunoassay for human interleukin-13 secreted from NK3.3 cells using homogenous time-resolved fluorescence.
J Pharm Biomed Anal
; 28(1): 73-9, 2002 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-11861110
14.
Indazole-based potent and cell-active Mps1 kinase inhibitors: rational design from pan-kinase inhibitor anthrapyrazolone (SP600125).
J Med Chem
; 56(11): 4343-56, 2013 Jun 13.
Artigo
Inglês
| MEDLINE | ID: mdl-23634759
15.
Diaminopyridine-based potent and selective mps1 kinase inhibitors binding to an unusual flipped-Peptide conformation.
ACS Med Chem Lett
; 3(7): 560-4, 2012 Jul 12.
Artigo
Inglês
| MEDLINE | ID: mdl-24900510