Assessing retirement satisfaction and perceptions of retirement experiences.

A 2-part investigation developed a measure of retirement as a life transition. Study 1 generated items from interviews with retirees (n = 40) and service providers. Item analysis with recent retirees (n = 86) produced a 51-item Retirement Satisfaction Inventory assessing 6 areas: preretirement work functioning, adjustment and change, reasons for retirement, satisfaction with life in retirement, current sources of enjoyment, and leisure and physical activities. Study 2 examined a heterogeneous sample of men (n = 159) and women (n = 243) retires. Factor analyses produced internally consistent subscales. Moderate, but acceptable, test-retest reliability was demonstrated. Satisfaction scores correlated with concurrent measures and, together with pre- and postretirement experiences, discriminated 4 groups of voluntary and involuntary retirees. Few effects related to gender, socioeconomic status, length of retirement, and part-time employment were found.

Before the big time: early history of the Training School at Vineland, 1888 to 1949.

Leaders of the Training School at Vineland made major contributions to the field of mental retardation from 1890 to 1940. S. O. Garrison originated the cottage plan and emphasized education and self-support. E. R. Johnstone pioneered teacher training, published a journal, initiated social action programs, and established a research laboratory. H. H. Goddard standardized the Binet-Simon scales in the United States, validated heredity as a cause of mental retardation, and hosted the production of the first group intelligence tests. S. D. Porteus supplemented the Binet with measures of personality. E. A. Doll established that birth injury could cause mental retardation, investigated the educability of profoundly retarded individuals, produced the Vineland Social Maturity Scale, and fostered electroencephalographic research.

Autogenic training and dream recall.

The present study has investigated the relationship between Autogenic Training and dream recall for 112 participants in 16 beginning courses of 10 wk. Analyses confirmed the hypothesis that learning and practicing this relaxation technique enhanced dream recall.

Emotions in diary dreams.

Even though various investigations found a preponderance of negative emotions in dreams, the conclusion that human dream life is, in general, negatively toned is limited by several methodological issues. The present study made use of three different approaches to measure dream emotions: dream intensity rated by the dreamer, intensity rated by a judge, and scoring of explicitly mentioned emotions (Hall & Van de Castle, 1966). Results indicate that only in the case of external raters' estimates do negative emotions outweigh the positive ones; but in the case of self-ratings (i.e., those made by the dreamer himself/herself), the ratio was balanced. Analyses showed that this is mainly due to the underestimation of positive emotions in the external ratings. Additionally, a positive correlation was found between the intensity of dream emotions and dream recall frequency, whereas gender differences were nonsignificant as regards the emotional tone of diary dreams.

Respiratory mechanics and control of the ventilatory cycle in the garter snake.

We measured respiratory airflow and intrapulmonary pressure in spontaneously breathing garter snakes (Thamnophis sirtalis) before and after bilateral vagotomy. Each breathing cycle consisted of expiration, inspiration, and a breath-holding period with the glottis closed, as previously reported. Respiratory system compliance was very high compared with that of mammals (0.042 ml/cm H2O per g), but was considerably reduced when the animal was coiled. Resistance to airflow averaged 6.35 cm H2O per ml/sec. Lung volume during the breath-hold was usually above the relaxed volume of the system. Analysis of dynamic pressure-volume and flow-volume loops showed that both expiration and inspiration were active, and that little use was made of passive recoil pressure in expiration. Evidence that vagally mediated, volume-related feedback influenced the breathing pattern was found in some snakes, but this influence was weaker than in most mammals and other reptiles. The results suggest that breathing in snakes is mainly a centrally programmed process, not markedly dependent on respiratory system mechanics or neuromechanical feedback. This arrangement is advantageous in view of the high, posturally variable compliance and the frequent regional distortions of the respiratory system that result from the unique structure of these animals.

Restricted expression of the ron gene encoding the macrophage stimulating protein receptor during mouse development.

The human ron gene codes for a transmembrane protein tyrosine kinase which is a receptor for the macrophage stimulating protein. The ron receptor, together with the hepatocyte growth factor/scatter factor receptor encoded by the proto-oncogene met, and the product of the c-sea proto-oncogene, make up a family of structurally related receptors. We have cloned murine ron cDNA sequences and used them as probes for in situ hybridization and Northern blot experiments. We show that ron gene expression occurs relatively late in development, and is much more restricted than that of the met gene. ron gene expression is detected in specific areas of the central and the peripheric nervous system, as well as in discrete cells in developing bones, and in the glandular epithelia along the digestive tract.

Specific and redundant functions of the paralogous Hoxa-9 and Hoxd-9 genes in forelimb and axial skeleton patterning.

Using gene targeting, we have produced mice with a disruption of Hoxa-9 or Hoxd-9, two paralogous Abdominal B-related genes. During embryogenesis, these genes are expressed in limb buds and along the vertebral axis with anterior expression boundaries at the level of prevertebra #20 for Hoxa-9 and #23 for Hoxd-9. Skeletal analysis revealed homeotic transformations corresponding to anteriorisations of vertebrae #21 to #25 (L1 to L5) in the lumbar region of Hoxa-9-/- mutants; vertebrae #23 to #25 (L3 to L5) in the lumbar region together with vertebrae #28, #30 and #31 (S2, S4 and Ca1) in the sacrum and tail were anteriorized in Hoxd-9-/- mutants. Thus, anteriorisation of vertebrae #23 to #25 were common to both phenotypes. Subtle forelimb (but not hindlimb) defects, corresponding to a reduction of the humerus length and malformation of its deltoid crest, were also observed in Hoxd-9-/-, but not in Hoxa-9-/-, mutant mice. By intercrosses between these two lines of mutant mice, we have produced Hoxa-9/Hoxd-9 double mutants which exhibit synergistic limb and axial malformations consisting of: (i) an increase of penetrance and expressivity of abnormalities present in the single mutants, and (ii) novel limb alterations at the level of the forelimb stylopod and additional axial skeleton transformations. These observations demonstrate that the two paralogous genes Hoxa-9 and Hoxd-9 have both specific and redundant functions in lumbosacral axial skeleton patterning and in limb morphogenesis at the stylopodal level. Taken all together, the present and previously reported results show that disruption of different Hox genes can produce similar vertebral transformations, thus supporting a combinatorial code model for specification of vertebral identity by Hox genes.