The applications of internet of things in smart healthcare sectors: a bibliometric and deep study.

The recent attention garnered by Internet of Things (IoT) technology for its potential to alleviate challenges faced by healthcare systems, such as those resulting from an aging population and the rise in chronic illnesses, has underscored the significance of smart healthcare. Surprisingly, no bibliometric study has been conducted on this subject to date. Consequently, this investigation aims to provide a comprehensive overview of the longitudinal state and knowledge structure of IoT in smart healthcare. To achieve this, a content analysis tool is employed for academic research, facilitating the identification of key study themes, the growth trajectory of the research topic, the top journal sources, and the distribution of nations based on subject areas. The bibliometric evaluation encompasses 614 publications published in 14 journals spanning the period from 2016 to 2022. Employing bibliographic coupling analysis, the latest developments in IoT have been uncovered within the domain of smart healthcare. The findings reveal 11 primary research topic areas that have been the focus of scholarly discourse during this period. This study highlights that the computing paradigm and network connectivity emerge as the most prominent topics within this research domain. Blockchain-based security in healthcare closely follows as the second-largest topic discussed by scholars. Additionally, the analysis indicates a significant increase in total publications for the most popular topic, peaking around 2018.

Levonorgestrel intrauterine system and breast cancer risk: An updated systematic review and meta-analysis of observational studies.

Objectives: Levonorgestrel intrauterine sustained release system (LNG-IUS) is an intrauterine hormonal contraceptive device. Breast cancer (BC) was the most common type of cancer in women in the world in 2020. The relationship between LNG-IUS and BC is controversial. We conducted an updated meta-analysis (larger sample capacity and including Asian data) to explore whether LNG-IUS can increase the risk of BC. Study design: We performed a thorough review of peer-reviewed publications from January 2005 through November 2022 using combinations of search terms for BC risk and LNG-IUS in the PubMed, Cochrane, Embase, Science Direct, and Web of Science databases. Studies reporting BC risk estimates among users of LNG-IUS were included according to the PRISMA criteria. Two authors independently evaluated all studies identified from the databases using Endnote software, and a third author resolved disagreements. The quality of evidence was evaluated using the Newcastle‒Ottawa Scale (NOS). A funnel plot was generated to assess publication bias. Results: We identified 3029 studies; 12 studies were included in our systematic review, and 6 studies involving 261,221 women were included in our meta-analysis. Two subgroup analyses were performed for different study designs. A total of 190,475 women were included in the meta-analysis of cohort studies, and the results were RR = 0.80 (95% CI 0.57-1.11, Z = 1.33, P = 0.18 > 0.05). The meta-analysis of the case‒control studies included 70,746 women, and the results were OR = 1.38 (95% CI 0.98-1.94, Z = 1.85, P = 0.06 > 0.05). Conclusions: Evidence of an increased risk of BC was not observed among LNG-IUS users. Implications: There are inconsistencies in existing studies that prevent us from confirming whether LNG-IUS can increase the risk of BC. Our updated meta-analysis preliminarily suggested that LNG-IUS did not increase the risk of BC, providing evidence for more clinically safe use and thus providing a better choice for contraception.