[The production and physicochemical characteristics of new pyridazinyl-3-methyl-4-phenylazo-5-pyrazolones]. / Obtinerea si caracterizarea fizico-chimica a unor noi piridazinil-3-metil-4-fenilazo-5-pirazolone.

The synthesis of eight new 1-(R-pyridazinil)-3-methyl-4-(R-phenylazo)-5-pyrazolone, the structure of which was confirmed by the results of the physicochemical analysis, is presented. The preliminary tests for determining their biological action have revealed a moderate antimicrobial activity.

[Diazabicyclic systems (VII). Cycloaddition reactions of benzocinnoline via ylidic intermediates]. / Systèmes diazabicycliques (VII). Réactions de cycloaddition par l'intermède des ylures de la benzo[c]-cinnoline.

By the reaction of p-bromo-phenacyl bromide on the 3,8-dimethyl- and the 3,8-di-methoxy-benzocinnoline, a cycloimmonium salts was obtained which, in the presence of triethylamine, was converted to benzocinnolinium-phenacylides. The existence in situ of the ylids was furnished evidence of the 3+2 dipolar cyclo- addition reactions with various dipolarophiles, such dimethyl and diethyl acetylenedicarboxylate, diethyl propiolate and also with diethyl azodicarboxylate. Thus, the application of the 1.3-dipolar additions is a successful route for the synthesis of some new bicyclic two nitrogen bridged systems.

[New derivatives of pyrazolo- and tetrazolobenzoquinolines with antimicrobial action]. / Noi derivati de pirazolo- si tetrazolo-benzocinolina cu actiune antimicrobiana.

The conditions for obtaining and the properties of some new diazabicyclic compounds is the new step in our investigation on the benzocynoline derivatives. The structure of the new compounds was confirmed by elementary (C, H, N) and spectral analyses. The antimicrobial tests evidenced that part of the newly synthetized compounds have a good antifungal action.

[The reaction of 3-(R-phenyl)-6-hydrazine pyridazine with 5-methylisatin and 1-morpholinomethyl-5-methylisatin]. / La réaction de la 3-(R-phényle)-6-hydrazino-pyridazine avec la 5-méthyl-isatine et la 1-morpholinométhyl-5-méthyl-isatine.

This paper presents the synthesis of six hydrazones obtained by treating 5-methyl-isatin or 1-morpholino methyl-5-methyl-isatin with 3-(R-phenyl)-6-hydrazino-pyridazine (R = OCH3, Cl, Br) and two complex combination with copper, derived from 3-(p-anisyl-pyridazinyl)-hydrazone-5-methyl-indoline-2- one. The structure of the new compounds was confirmed by the results of the quantitative elementary and IR, UV-VIS spectral analysis. The biological tests point out that product VI, in which a copper atom binds two molecules of 3-(p-anisyl-pyridazinyl)-hydrazono-5-methyl-indoline-2-one, has a considerable antiinflammatory activity, giving a inflammation inhibition of 39, 6%. All the synthetized compounds have a moderate antimicrobial activity against Candida albicans.

Hydrazones and formazans with possible biological activity.

This paper presents a synthesis about some hydrazones, formazans and copper's complexes combinations. The structure of the new compounds was confirmed by the results of the quantitative elementary and IR spectral analysis. The antimicrobial and antiinflammatory activities were investigated.

Tetrazolium salts and metal complexes of some formazans.

This paper presents the synthesis of some tetrazolium salts and metal complexes combinations, which are derived from aromatic and heterocyclic formazans. Elemental quantitative analyses and spectral data confirmed the structure of the new synthesized compounds. The new synthesized compounds were submitted to microbiological tests.

[The reaction of 3-(R-phenyl)-6-hydrazine pyridazines with substituted isatins (II)]. / La réaction de certaines 3-(R-phényle)-6-hydrazino-pyridazines avec des isatines substituées (II).

This paper presents the synthesis of six hydrazones from isatin and 1-morpholinomethyl-isatin and also of their six cooper's complex salts. Their structure was confirmed by the results of the quantitative elemental analysis and by IR, UV-VIS spectral analysis. The biological tests point out that cooper's complex salt of 3-(3'-phenyl-pyridazinylhydrazono)-5-methyl-indoline-2-one (1:2) (VI a) has the smallest toxicity (DMT over 800 mg/kg.w. p.o.), a remarkable anti-inflammatory activity (inhibition 57.1%, IAR 1.1) and also a gastroprotector coefficient of 43.3%. In the mean time, the cooper's complex salt of 3-(3'-p-anisyl-pyridazinyl-hydrazono)-5-methyl-ind oline-2-one (1:2) (VI b) has a gastroprotector coefficient of 76.3% and a lower anti-inflammatory activity than the first derivative (inhibition 36.9%).

[New isatin-derived hydrazones and Mannich bases with possible biological activity]. / Noi hidrazone si baze Mannich derivate de la isatina, cu eventuala activitate biologica.

The paper presents a synthesis of six new Mannich bases, five hydrazones derived from 1-piperidino-methyl-5-R-isatin and three copper complex compounds of 3-(3'-R-phenyl-pyridazinil-hydrazone)-indoline-2-ones (R=H, CH3, OCH3). The structure of the new compounds was confirmed by the results of the elementary and spectral analysis. Pharmacodynamic studies indicated that copper complex compounds present effective biological properties. Thus, it can be seen that the experimental carrageenan-induced inflammatory oedema was 58.3% inhibited by the complex V (R=CH3) after oral administration. Antimicrobial tests revealed that only compound V (R=OCH3) shows a moderate antimicrobial activity against the gram-positive and gram-negative bacteria, used in the test.