1.
Angew Chem Int Ed Engl
; 51(45): 11258-62, 2012 Nov 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23042634
RESUMO
Capturing a coactivator, naturally: the natural products sekikaic acid and lobaric acid, isolated after a high-throughput screen of a structurally diverse extract collection, effectively target the dynamic binding interfaces of the GACKIX domain of the coactivator CBP/p300. These molecules are the most effective inhibitors of the GACKIX domain yet described and are uniquely selective for this domain.