Detalhe da pesquisa
1.
A novel humanized mouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles.
Hum Mol Genet
; 26(6): 1115-1132, 2017 03 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28104789
2.
HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity.
Hum Mol Genet
; 24(11): 3257-71, 2015 Jun 01.
Artigo
Inglês
| MEDLINE | ID: mdl-25740845
3.
Huntingtin Haplotypes Provide Prioritized Target Panels for Allele-specific Silencing in Huntington Disease Patients of European Ancestry.
Mol Ther
; 23(11): 1759-1771, 2015 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-26201449
4.
Bidirectional control of postsynaptic density-95 (PSD-95) clustering by Huntingtin.
J Biol Chem
; 289(6): 3518-28, 2014 Feb 07.
Artigo
Inglês
| MEDLINE | ID: mdl-24347167
5.
Hip14l-deficient mice develop neuropathological and behavioural features of Huntington disease.
Hum Mol Genet
; 22(3): 452-65, 2013 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23077216
6.
A fully humanized transgenic mouse model of Huntington disease.
Hum Mol Genet
; 22(1): 18-34, 2013 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23001568
7.
In vivo evaluation of candidate allele-specific mutant huntingtin gene silencing antisense oligonucleotides.
Mol Ther
; 22(12): 2093-2106, 2014 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-25101598
8.
Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS.
Nucleic Acids Res
; 41(21): 9634-50, 2013 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-23963702
9.
High frequency of intermediate alleles on Huntington disease-associated haplotypes in British Columbia's general population.
Am J Med Genet B Neuropsychiatr Genet
; 162B(8): 864-71, 2013 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-24038799
10.
Potent and selective antisense oligonucleotides targeting single-nucleotide polymorphisms in the Huntington disease gene / allele-specific silencing of mutant huntingtin.
Mol Ther
; 19(12): 2178-85, 2011 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-21971427
11.
Reliable Resolution of Full-Length Huntingtin Alleles by Quantitative Immunoblotting.
J Huntingtons Dis
; 10(3): 355-365, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-34092649
12.
Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus.
Hum Mol Genet
; 17(15): 2390-404, 2008 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-18445618
13.
Phosphorylation of huntingtin reduces the accumulation of its nuclear fragments.
Mol Cell Neurosci
; 40(2): 121-7, 2009 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-18992820
14.
Huntingtin suppression restores cognitive function in a mouse model of Huntington's disease.
Sci Transl Med
; 10(461)2018 10 03.
Artigo
Inglês
| MEDLINE | ID: mdl-30282695
15.
A SNP in the HTT promoter alters NF-κB binding and is a bidirectional genetic modifier of Huntington disease.
Nat Neurosci
; 18(6): 807-16, 2015 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-25938884
16.
Allele-specific suppression of mutant huntingtin using antisense oligonucleotides: providing a therapeutic option for all Huntington disease patients.
PLoS One
; 9(9): e107434, 2014.
Artigo
Inglês
| MEDLINE | ID: mdl-25207939
17.
Huntington disease in the South African population occurs on diverse and ethnically distinct genetic haplotypes.
Eur J Hum Genet
; 21(10): 1120-7, 2013 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-23463025
18.
HTT haplotypes contribute to differences in Huntington disease prevalence between Europe and East Asia.
Eur J Hum Genet
; 19(5): 561-6, 2011 May.
Artigo
Inglês
| MEDLINE | ID: mdl-21248742
19.
Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.
Cell
; 125(6): 1179-91, 2006 Jun 16.
Artigo
Inglês
| MEDLINE | ID: mdl-16777606