Detalhe da pesquisa
1.
Identification of 2-Sulfonyl/Sulfonamide Pyrimidines as Covalent Inhibitors of WRN Using a Multiplexed High-Throughput Screening Assay.
Biochemistry
; 62(14): 2147-2160, 2023 07 18.
Artigo
Inglês
| MEDLINE | ID: mdl-37403936
2.
Identification and pharmacological characterization of multiple allosteric binding sites on the free fatty acid 1 receptor.
Mol Pharmacol
; 82(5): 843-59, 2012 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-22859723
3.
Cardiovascular response to small-molecule APJ activation.
JCI Insight
; 5(8)2020 04 23.
Artigo
Inglês
| MEDLINE | ID: mdl-32208384
4.
Discovery of AM-6226: A Potent and Orally Bioavailable GPR40 Full Agonist That Displays Efficacy in Nonhuman Primates.
ACS Med Chem Lett
; 9(7): 757-760, 2018 Jul 12.
Artigo
Inglês
| MEDLINE | ID: mdl-30034614
5.
5-Alkyl-2-urea-Substituted Pyridines: Identification of Efficacious Glucokinase Activators with Improved Properties.
ACS Med Chem Lett
; 7(7): 666-70, 2016 Jul 14.
Artigo
Inglês
| MEDLINE | ID: mdl-27437074
6.
Novel Series of Potent Glucokinase Activators Leading to the Discovery of AM-2394.
ACS Med Chem Lett
; 7(7): 714-8, 2016 Jul 14.
Artigo
Inglês
| MEDLINE | ID: mdl-27437083
7.
Highly regioselective Diels-Alder reactions toward oroidin alkaloids: use of a tosylvinyl moiety as a nitrogen masking group with adjustable electronics.
Org Lett
; 7(9): 1679-82, 2005 Apr 28.
Artigo
Inglês
| MEDLINE | ID: mdl-15844879
8.
Divergent approach to imino sugar C-glycosides using imino glycals: application to the stereocontrolled synthesis of (+)-deoxoprosophylline.
Chem Commun (Camb)
; (2): 150-1, 2002 Jan 21.
Artigo
Inglês
| MEDLINE | ID: mdl-12120347
9.
Improving the Pharmacokinetics of GPR40/FFA1 Full Agonists.
ACS Med Chem Lett
; 5(4): 384-9, 2014 Apr 10.
Artigo
Inglês
| MEDLINE | ID: mdl-24900845
10.
Optimization of GPR40 Agonists for Type 2 Diabetes.
ACS Med Chem Lett
; 5(5): 517-21, 2014 May 08.
Artigo
Inglês
| MEDLINE | ID: mdl-24900872
11.
C5-Alkyl-2-methylurea-Substituted Pyridines as a New Class of Glucokinase Activators.
ACS Med Chem Lett
; 5(12): 1284-9, 2014 Dec 11.
Artigo
Inglês
| MEDLINE | ID: mdl-25516785
12.
Activation of FFA1 mediates GLP-1 secretion in mice. Evidence for allosterism at FFA1.
Mol Cell Endocrinol
; 369(1-2): 119-29, 2013 Apr 30.
Artigo
Inglês
| MEDLINE | ID: mdl-23403053
13.
Discovery and Optimization of Potent GPR40 Full Agonists Containing Tricyclic Spirocycles.
ACS Med Chem Lett
; 4(6): 551-5, 2013 Jun 13.
Artigo
Inglês
| MEDLINE | ID: mdl-24900707
14.
Discovery of AM-1638: A Potent and Orally Bioavailable GPR40/FFA1 Full Agonist.
ACS Med Chem Lett
; 3(9): 726-30, 2012 Sep 13.
Artigo
Inglês
| MEDLINE | ID: mdl-24900539
15.
A potent class of GPR40 full agonists engages the enteroinsular axis to promote glucose control in rodents.
PLoS One
; 7(10): e46300, 2012.
Artigo
Inglês
| MEDLINE | ID: mdl-23056280
16.
Preparation and reactivity of imino glycals: stereocontrolled, divergent approach to imino sugars.
Org Biomol Chem
; 1(15): 2723-33, 2003 Aug 07.
Artigo
Inglês
| MEDLINE | ID: mdl-12948197