Severe disturbance of glucose metabolism in peripheral blood mononuclear cells of schizophrenia patients: a targeted metabolomic study.

BACKGROUND: Schizophrenia is a widespread and debilitating mental disorder. However, the underlying molecular mechanism of schizophrenia remains largely unknown and no objective laboratory tests are available to diagnose this disorder. The aim of the present study was to characterize the alternations of glucose metabolites and identify potential diagnostic biomarkers for schizophrenia. METHODS: Gas chromatography/mass spectrometry based targeted metabolomic method was used to quantify the levels of 13 glucose metabolites in peripheral blood mononuclear cells (PBMCs) derived from healthy controls, schizophrenia and major depression subjects (n = 55 for each group). RESULTS: The majority (84.6%) of glucose metabolites were significantly disturbed in schizophrenia subjects, while only two (15.4%) glucose metabolites were differently expressed in depression subjects relative to healthy controls in both training set (n = 35/group) and test set (n = 20/group). Antipsychotics had only a subtle effect on glucose metabolism pathway. Moreover, ribose 5-phosphate in PBMCs showed a high diagnostic performance for first-episode drug-naïve schizophrenia subjects. CONCLUSION: These findings suggested disturbance of glucose metabolism may be implicated in onset of schizophrenia and could aid in development of diagnostic tool for this disorder.

Multi-environment mapping and meta-analysis of 100-seed weight in soybean.

100-Seed weight (100-SW) of soybean is an important but complicated quantitative trait to yield. This study was focus on the quantitative trait loci (QTLs) of soybean 100-SW from 2006 to 2010, using recombination inbred lines population that was derived from a cross between Charleston and Dongnong 594. A total of 23 QTLs for 100-SW were detected in the linkage group C2, D1a, F, G and O. Nine QTLs were identified by composite interval mapping including one QTL with the minimum confidence interval (CI) of 1.3 cM, while 14 QTLs by multiple interval mapping. Furthermore, 94 reported QTLs of 100-SW were integrated with our QTL mapping results using BioMercator. As a result, 15 consensus QTLs and their corresponding markers were identified. The minimum CI was reduced to 1.52 cM by the combination of meta-analysis. These findings may merit fine-mapping of these QTL in soybean.

Association between physical activity and online sexual objectification experience: The mediating role of body-image depression.

Objective: With the popularization and development of online media technology, more and more women are paying attention to their body image and physical behavior. The purpose of this study was to investigate the effect of online sexual objectification experience on the physical activity of female college students and verify the mediating role of body-image depression between them. Methods: A cross-sectional convenient sample of 882 female college students from four universities in Hubei Province completed an online survey, and the Online Sexual Objectification Experience Scale (OSOES), the Body-Image Depression Questionnaire, and the Physical Activity Rating Scale (PARS) were used to collect the data. The mediating effect of the association between online sexual objectification experience and physical activity, was examined using the process procedure in SPSS and the bootstrap method. Results: Online sexual objectification experience was significantly positively correlated with physical activity (r = 0.420, p < 0.01). Body-image depression was significantly negatively correlated with online sexual objectification experience and physical activity (r = -0.484, p < 0.01; r = -0.569, p < 0.01). Online sexual objectification experience can affect physical activity directly (ß = 6.49, p < 0.001, effect value 44.97%) and also indirectly through body-image depression (ß = 7.95, p < 0.001, effect value 55.03%); there were significant differences between major and education-level categories in body-image depression and physical activity. Conclusion: Both online sexual objectification experience and body-image depression can promote physical activity among female college students, and body-image depression has a mediating effect between online sexual objectification experience and physical activity.