RESUMO
A novel pH-responsive probe based on an imidazo[1,2-a]indole fluorophore architecture is reported. The probe was highly selective to strongly acidic pH (pKa = 3.56) with high sensitivity and a fast response time (within 30 s). The probe did not demonstrate any fluorescence changes in the presence of interfering metal ions, and it featured excellent reversibility under strongly acidic conditions. The mechanism of detection of the probe was determined to be based on intramolecular charge transfer (ICT) at different pH. The probe was also able to be used for imaging for detecting acidic pH in Saccharomyces cerevisiae.
Assuntos
Corantes Fluorescentes , Saccharomyces cerevisiae , Células HeLa , Humanos , Concentração de Íons de Hidrogênio , IndóisRESUMO
Construction of new system and exploration of new approach are of great importance for the improvement of their photophysical properties to meet the growing various uses of phosphorescent materials. Triphenylmethane (TPM), composed only of carbon and hydrogen, exhibits excellent color tunable phosphorescence in air, with ultralong lifetime (836â ms), and wide color-tunable range (from cyan to green, then to yellow and finally to orange, 525â nm-616â nm). Through careful comparison with the single crystal diffraction structure of tetraphenylmethane (TTPM) and theoretical calculation analysis, we believe that various clusters formed through space interactions are crucial for color-tunable phosphorescence.
RESUMO
This study aimed to investigate risk factors (such as morning hypertension, drug compliance, and biochemical parameters) of macrovascular events after cerebral infarction.This was a retrospective study of patients with cerebral infarction admitted between May 2015 and April 2016 at the Fengxian Branch, 6th People's Hospital of Shanghai. They were divided into the macrovascular events and control groups according to the diagnosis of macrovascular events following cerebral infarction.Among the 702 patients included for analysis, 122 patients were with macrovascular events and 580 were without macrovascular events (controls). Morning hypertension (Pâ=â.01), dyslipidemia (Pâ=â.007), atrial fibrillation (Pâ=â.039), carotid artery plaque (Pâ=â.014), inflammatory infection (Pâ=â.005), high homocysteine (Pâ=â.032), antithrombotic compliance (Pâ<â.001), statins compliance (Pâ<â.001), morning diastolic blood pressure (Pâ<â.001), morning systolic blood pressure (Pâ<â.001), and morning heart rate (morHR) (Pâ=â.033) were associated with macrovascular events. Multivariable analysis showed that morning hypertension (Pâ=â.021, odds ratio [OR]â=â1.753, 95% confidence interval [CI] [1.088, 2.826]), dyslipidemia (Pâ=â.021, ORâ=â1.708, 95% CI [1.085, 2.687]), and inflammatory infection (Pâ=â.031, ORâ=â2.263, 95% CI [1.078, 4.752]) were independent risk factors for macrovascular events, while antithrombotic compliance (Pâ<â.001, ORâ=â0.488, 95% CI [0.336, 0.709]), statin compliance (Pâ=â.02, ORâ=â0.64, 95% CI [0.44, 0.931]), and morHR (Pâ=â.027, ORâ=â0.977, 95% CI [0.958, 0.997]) were independent protective factors against macrovascular events. Atrial fibrillation showed a tendency to be associated with macrovascular events (Pâ=â.077, ORâ=â1.531, 95% CI [0.955, 2.454]).Morning hypertension, dyslipidemia, and inflammatory infection may increase the risk of macrovascular events following cerebral infarction. Improving morning blood pressure management and drug compliance (antithrombotic drugs and statins) may reduce the risk of macrovascular events following cerebral infarction.