Detalhe da pesquisa
1.
Genetic resistance to purine nucleoside phosphorylase inhibition in Plasmodium falciparum.
Proc Natl Acad Sci U S A
; 115(9): 2114-2119, 2018 02 27.
Artigo
Inglês
| MEDLINE | ID: mdl-29440412
2.
Mycobacterium tuberculosis Shikimate Pathway Enzymes as Targets for the Rational Design of Anti-Tuberculosis Drugs.
Molecules
; 25(6)2020 Mar 11.
Artigo
Inglês
| MEDLINE | ID: mdl-32168746
3.
Kinetic Isotope Effects and Transition State Structure for Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase from Plasmodium falciparum.
Biochemistry
; 56(48): 6368-6376, 2017 Dec 05.
Artigo
Inglês
| MEDLINE | ID: mdl-29131588
4.
Continuous Fluorescence Assays for Reactions Involving Adenine.
Anal Chem
; 88(23): 11860-11867, 2016 12 06.
Artigo
Inglês
| MEDLINE | ID: mdl-27779859
5.
Discovery of new inhibitors of Mycobacterium tuberculosis InhA enzyme using virtual screening and a 3D-pharmacophore-based approach.
J Chem Inf Model
; 53(9): 2390-401, 2013 Sep 23.
Artigo
Inglês
| MEDLINE | ID: mdl-23889525
6.
MAT Gain of Activity Mutation in Helicobacter pylori Is Associated with Resistance to MTAN Transition State Analogues.
ACS Infect Dis
; 9(4): 966-978, 2023 04 14.
Artigo
Inglês
| MEDLINE | ID: mdl-36920074
7.
Biochemical characterization of recombinant guaA-encoded guanosine monophosphate synthetase (EC 6.3.5.2) from Mycobacterium tuberculosis H37Rv strain.
Arch Biochem Biophys
; 517(1): 1-11, 2012 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22119138
8.
Inhibition and Mechanism of Plasmodium falciparum Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase.
ACS Chem Biol
; 17(12): 3407-3419, 2022 12 16.
Artigo
Inglês
| MEDLINE | ID: mdl-36413975
9.
Molecular, kinetic, thermodynamic, and structural analyses of Mycobacterium tuberculosis hisD-encoded metal-dependent dimeric histidinol dehydrogenase (EC 1.1.1.23).
Arch Biochem Biophys
; 512(2): 143-53, 2011 08 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21672513
10.
Structural and functional analyses of Mycobacterium tuberculosis Rv3315c-encoded metal-dependent homotetrameric cytidine deaminase.
J Struct Biol
; 169(3): 413-23, 2010 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-20035876
11.
The kinetic mechanism of human uridine phosphorylase 1: Towards the development of enzyme inhibitors for cancer chemotherapy.
Arch Biochem Biophys
; 497(1-2): 35-42, 2010 May.
Artigo
Inglês
| MEDLINE | ID: mdl-20226755
12.
Crystallographic and docking studies of purine nucleoside phosphorylase from Mycobacterium tuberculosis.
Bioorg Med Chem
; 18(13): 4769-74, 2010 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20570524
13.
Substrate specificity and kinetic mechanism of purine nucleoside phosphorylase from Mycobacterium tuberculosis.
Arch Biochem Biophys
; 486(2): 155-64, 2009 Jun 15.
Artigo
Inglês
| MEDLINE | ID: mdl-19416718
14.
Antibacterial Strategy against H. pylori: Inhibition of the Radical SAM Enzyme MqnE in Menaquinone Biosynthesis.
ACS Med Chem Lett
; 10(3): 363-366, 2019 Mar 14.
Artigo
Inglês
| MEDLINE | ID: mdl-30891141
15.
Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase.
J Med Chem
; 62(7): 3286-3296, 2019 04 11.
Artigo
Inglês
| MEDLINE | ID: mdl-30860833
16.
Biofilm Inhibition via Delivery of Novel Methylthioadenosine Nucleosidase Inhibitors from PVA-Tyramine Hydrogels while Supporting Mesenchymal Stromal Cell Viability.
ACS Biomater Sci Eng
; 5(2): 748-758, 2019 Feb 11.
Artigo
Inglês
| MEDLINE | ID: mdl-33405836
17.
Transition-State Analogues of Campylobacter jejuni 5'-Methylthioadenosine Nucleosidase.
ACS Chem Biol
; 13(11): 3173-3183, 2018 11 16.
Artigo
Inglês
| MEDLINE | ID: mdl-30339406
18.
Synthesis of bis-Phosphate Iminoaltritol Enantiomers and Structural Characterization with Adenine Phosphoribosyltransferase.
ACS Chem Biol
; 13(1): 152-160, 2018 01 19.
Artigo
Inglês
| MEDLINE | ID: mdl-29178779
19.
Transition-state inhibitors of purine salvage and other prospective enzyme targets in malaria.
Future Med Chem
; 5(11): 1341-60, 2013 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-23859211
20.
Crystal structure and molecular dynamics studies of purine nucleoside phosphorylase from Mycobacterium tuberculosis associated with acyclovir.
Biochimie
; 94(1): 155-65, 2012 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-22033138