Detalhe da pesquisa
1.
A phase I, randomized, double-blind, placebo-controlled, ascending single- and multiple-dose study of the pharmacokinetics, safety, and tolerability of oral ceftibuten in healthy adult subjects.
Antimicrob Agents Chemother
; 68(1): e0109923, 2024 Jan 10.
Artigo
Inglês
| MEDLINE | ID: mdl-38059635
2.
A Phase 1 Study of the Safety, Tolerability, and Pharmacokinetics of Biapenem in Healthy Adult Subjects.
Antimicrob Agents Chemother
; 65(5)2023 05 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33685898
3.
Spectrum of Beta-Lactamase Inhibition by the Cyclic Boronate QPX7728, an Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases: Enhancement of Activity of Multiple Antibiotics against Isogenic Strains Expressing Single Beta-Lactamases.
Antimicrob Agents Chemother
; 64(6)2020 05 21.
Artigo
Inglês
| MEDLINE | ID: mdl-32229489
4.
Impact of Intrinsic Resistance Mechanisms on Potency of QPX7728, a New Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases in Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii.
Antimicrob Agents Chemother
; 64(6)2020 05 21.
Artigo
Inglês
| MEDLINE | ID: mdl-32229498
5.
Polymyxin Susceptibility Testing and Interpretive Breakpoints: Recommendations from the United States Committee on Antimicrobial Susceptibility Testing (USCAST).
Antimicrob Agents Chemother
; 64(2)2020 01 27.
Artigo
Inglês
| MEDLINE | ID: mdl-31767718
6.
Pharmacodynamics of Minocycline against Acinetobacter baumannii in a Rat Pneumonia Model.
Antimicrob Agents Chemother
; 63(2)2019 02.
Artigo
Inglês
| MEDLINE | ID: mdl-30397059
7.
Pharmacokinetics/Pharmacodynamics of Vaborbactam, a Novel Beta-Lactamase Inhibitor, in Combination with Meropenem.
Antimicrob Agents Chemother
; 63(1)2019 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30397063
8.
Single Intravenous Dose of Oritavancin for Treatment of Acute Skin and Skin Structure Infections Caused by Gram-Positive Bacteria: Summary of Safety Analysis from the Phase 3 SOLO Studies.
Antimicrob Agents Chemother
; 62(4)2018 04.
Artigo
Inglês
| MEDLINE | ID: mdl-29358292
9.
In Vitro Activity of Meropenem-Vaborbactam against Clinical Isolates of KPC-Positive Enterobacteriaceae.
Antimicrob Agents Chemother
; 62(1)2018 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29084745
10.
A Retrospective Cohort Analysis Shows that Coadministration of Minocycline with Colistin in Critically Ill Patients Is Associated with Reduced Frequency of Acute Renal Failure.
Antimicrob Agents Chemother
; 62(1)2018 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29038261
11.
Phase 1 Study of the Safety, Tolerability, and Pharmacokinetics of Vaborbactam and Meropenem Alone and in Combination following Single and Multiple Doses in Healthy Adult Subjects.
Antimicrob Agents Chemother
; 62(4)2018 04.
Artigo
Inglês
| MEDLINE | ID: mdl-29437614
12.
Single-Dose Pharmacokinetics and Safety of Meropenem-Vaborbactam in Subjects with Chronic Renal Impairment.
Antimicrob Agents Chemother
; 62(3)2018 03.
Artigo
Inglês
| MEDLINE | ID: mdl-29311069
13.
Activity of Meropenem-Vaborbactam in Mouse Models of Infection Due to KPC-Producing Carbapenem-Resistant Enterobacteriaceae.
Antimicrob Agents Chemother
; 62(1)2018 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29109160
14.
Activity of Simulated Human Dosage Regimens of Meropenem and Vaborbactam against Carbapenem-Resistant Enterobacteriaceae in an In Vitro Hollow-Fiber Model.
Antimicrob Agents Chemother
; 62(2)2018 02.
Artigo
Inglês
| MEDLINE | ID: mdl-29133570
15.
Effect of Meropenem-Vaborbactam vs Piperacillin-Tazobactam on Clinical Cure or Improvement and Microbial Eradication in Complicated Urinary Tract Infection: The TANGO I Randomized Clinical Trial.
JAMA
; 319(8): 788-799, 2018 02 27.
Artigo
Inglês
| MEDLINE | ID: mdl-29486041
16.
Progress in the Fight Against Multidrug-Resistant Bacteria 2005-2016: Modern Noninferiority Trial Designs Enable Antibiotic Development in Advance of Epidemic Bacterial Resistance.
Clin Infect Dis
; 65(1): 141-146, 2017 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29017263
17.
Meropenem-Vaborbactam Resistance Selection, Resistance Prevention, and Molecular Mechanisms in Mutants of KPC-Producing Klebsiella pneumoniae.
Antimicrob Agents Chemother
; 61(12)2017 12.
Artigo
Inglês
| MEDLINE | ID: mdl-29038260
18.
Vaborbactam: Spectrum of Beta-Lactamase Inhibition and Impact of Resistance Mechanisms on Activity in Enterobacteriaceae.
Antimicrob Agents Chemother
; 61(11)2017 11.
Artigo
Inglês
| MEDLINE | ID: mdl-28848018
19.
Effects of Oritavancin on Coagulation Tests in the Clinical Laboratory.
Antimicrob Agents Chemother
; 61(2)2017 02.
Artigo
Inglês
| MEDLINE | ID: mdl-27956417
20.
Phase 1 Study of the Safety, Tolerability, and Pharmacokinetics of the ß-Lactamase Inhibitor Vaborbactam (RPX7009) in Healthy Adult Subjects.
Antimicrob Agents Chemother
; 60(10): 6326-32, 2016 10.
Artigo
Inglês
| MEDLINE | ID: mdl-27527080