Global resting-state functional connectivity of neural oscillations in tinnitus with and without hearing loss.

This study examined global resting-state functional connectivity of neural oscillations in individuals with chronic tinnitus and normal and impaired hearing. We tested the hypothesis that distinct neural oscillatory networks are engaged in tinnitus with and without hearing loss. In both tinnitus groups, with and without hearing loss, we identified multiple frequency band-dependent regions of increased and decreased global functional connectivity. We also found that the auditory domain of tinnitus severity, assayed by the Tinnitus Functional Index, was associated with global functional connectivity in both auditory and nonauditory regions. These findings provide candidate biomarkers to target and monitor treatments for tinnitus with and without hearing loss.

Exergy Analysis of Advanced Adsorption Cooling Cycles.

This study conducted an exergy analysis of advanced adsorption cooling cycles. The possible exergy losses were divided into internal losses and external losses, and the exergy losses of each process in three advanced cycles: a mass recovery cycle, heat recovery cycle and combined heat and mass recovery cycle were calculated. A transient two-dimensional numerical model was used to solve the heat and mass transfer kinetics. The exergy destruction of each component and process in a finned tube type, silica gel/water working paired-adsorption chiller was estimated. The results showed that external loss was significantly reduced at the expense of internal loss. The mass recovery cycle reduced the total loss to 60.95 kJ/kg, which is -2.76% lower than the basic cycle. In the heat recovery cycle, exergy efficiency was significantly enhanced to 23.20%. The optimum value was 0.1248 at a heat recovery time of 60 s. The combined heat and mass recovery cycle resulted in an 11.30% enhancement in exergy efficiency, compared to the heat recovery cycle. The enhancement was much clearer when compared to the basic cycle, with 37.12%. The observed dependency on heat recovery time and heating temperature was similar to that observed for individual mass recovery and heat recovery cycles.

Interaction of Functionalized Naphthalenophanes with Abasic Sites in DNA: DNA Cleavage, DNA Cleavage Inhibition, and Formation of Ligand-DNA Adducts.

Ligands interacting with abasic (AP) sites in DNA may generate roadblocks in base-excision DNA repair (BER) due to indirect inhibition of DNA repair enzymes (e.g., APE1) and/or formation of toxic byproducts, resulting from ligand-induced strand cleavage or covalent cross-links. Herein, a series of 12 putative AP-site ligands, sharing the common naphthalenophane scaffold, but endowed with a variety of substituents, have been prepared and systematically studied. The results demonstrate that most naphthalenophanes bind to AP sites in DNA and inhibit the APE1-induced hydrolysis of the latter in vitro. Remarkably, their APE1 inhibitory activity, as characterized by IC50 and KI values, can be directly related to their affinity and selectivity to AP sites, as assessed by means of fluorescence melting experiments. On the other hand, the molecular design of naphthalenophanes has a crucial influence on their intrinsic AP-site cleavage activity (i.e., ligand-catalyzed ß- and ß,δ-elimination reactions at the AP site), as illustrated by the compounds either having an exceptionally high AP-site cleavage activity (e.g., 2,7-BisNP-S, 125-fold more efficacious than spermine) or being totally devoid of this activity (four compounds). Finally, the unprecedented formation of a stable covalent DNA adduct upon reaction of one ligand (2,7-BisNP-NH) with its own product of the AP-site cleavage is revealed.

Use of real-time QPCR in biokinetics and modeling of two different ammonia-oxidizing bacteria growing simultaneously.

A real-time quantitative polymerase chain reaction (QPCR) was used to evaluate biokinetic coefficients of Nitrosomonas nitrosa and N. cryotolerans clusters growing simultaneously in a batch mode of ammonia oxidation. The mathematical models based on Monod equation were employed to describe the competitive relationship between these clusters and were fitted to experimental data to obtain biokinetic values. The maximum growth rates (µ(m)), half-saturation coefficients (K(S)), microbial yields (Y) and decay coefficients (k(d)) of N. nitrosa and N. cryotolerans were 1.77 and 1.21 day(-1), 23.25 and 23.06 mg N·L(-1), 16 × 10(8) and 1 × 10(8) copies·mg N(-1), 0.26 and 0.20 day(-1), respectively. The estimated coefficients were applied for modeling continuous operations at various hydraulic retention times (HRTs) with an influent ammonia concentration of 300 mg N·L(-1). Modeling results revealed that ammonia oxidation efficiencies were achieved 55-98 % at 0.8-10 days HRTs and that the system was predicted to be washed out at HRT of 0.7 days. Overall, use of QPCR for estimating biokinetic coefficients of the two AOB cluster growing simultaneously by use of ammonia were successful. This idea may open a new direction towards biokinetics of ammonia oxidation in which respirometry tests are usually employed.

Steam explosion as sustainable biomass pretreatment technique for biofuel production: Characteristics and challenges.

The biorefining process of lignocellulosic biomass has recently emerged as one of the most profitable biofuel production options. However, pretreatment is required to improve the recalcitrant lignocellulose's enzymatic conversion efficiency. Among biomass pretreatment methods, the steam explosion is an eco-friendly, inexpensive, and effective approach to pretreating biomass, significantly promoting biofuel production efficiency and yield. This review paper critically presents the steam explosion's reaction mechanism and technological characteristics for lignocellulosic biomass pretreatment. Indeed, the principles of steam explosion technology for lignocellulosic biomass pretreatment were scrutinized. Moreover, the impacts of process factors on pretreatment efficiency and sugar recovery for the following biofuel production were also discussed in detail. Finally, the limitations and prospects of steam explosion pretreatment were mentioned. Generally, steam explosion technology applications could bring great potential in pretreating biomass, although deeper studies are needed to deploy this method on industrial scales.

Integrated pest management of Hypsipyla robusta shoot-tip borer (Lepidoptera: Pyralidae) in Chukrasia tabularis (Sapindales: Meliaceae).

Chukrasia tabularis A. Juss produces a valuable timber but plantations are susceptible to attack by the shoot-tip borer Hypsipyla robusta Moore. An integrated pest management (IPM) approach is desirable to limit the extent of damage. Therefore, this study was undertaken to evaluate the deployment of IPM measures in plantations in Vietnam. Data on tree damage and the biology of H. robusta were gathered in 4 provinces over one year and used to build an investigation schedule. Two preliminary IPM trials were then established in which Bacillus thuringiensis and Metarhizium anisopliae were applied to the foliage when the damage incidence (P%) was in the range 5-10%; and insecticides (Carbaryl, Carbosulfan) were applied when the P% exceeded 10%. In addition, larvae and pupae were removed manually over time. In the first trial, the combination of manual and biological control methods reduced the damage index (DI) of trees from 4 tolerant families by 82% compared to the untreated control plots. In the second trial using standard planting stock, application of insecticides was required to reduce the DI by 83%. Six extended IPM trials were undertaken using the same IPM protocols and these reduced the DI to the same extent as in the preliminary trials. Over an 18-month period, the deployment of IPM increased height growth by 19-22% and diameter growth by 38-41% compared to the controls. These findings highlight the value of planting improved seed and the benefit of adopting an IPM approach to manage the shoot-tip borer.

Hydrothermal carbonization of food waste as sustainable energy conversion path.

Every day, a large amount of food waste (FW) is released into the environment, causing financial loss and unpredictable consequences in the world, highlighting the urgency of finding a suitable approach to treating FW. As moisture content makes up 75% of the FW, hydrothermal carbonization (HTC) is a beneficial process for the treatment of FW since it does not require extensive drying. Moreover, the process is considered favorable for carbon sequestration to mitigate climate change in comparison with other processes because the majority of the carbon in FW is integrated into hydrochar. In this work, the reaction mechanism and factors affecting the HTC of FW are scrutinized. Moreover, the physicochemical properties of products after the HTC of FW are critically presented. In general, HTC of FW is considered a promising approach aiming to attain simultaneously-two core benefits on economy and energy in the sustainable development strategy.

Binder ratio in the two-dimensional q-state clock model.

We study phase transition properties of the two-dimensional q-state clock model by an extensive Monte Carlo simulation. By analyzing the Binder ratio and its temperature derivative, we confirm that the two-dimensional q-state clock model exhibits two distinct Kosterlitz-Thouless phase transitions for q=5,6 but it has one second-order phase transition for q=4. The critical temperatures are estimated quite accurately from the crossing behavior of the Binder ratio (for q<5) and from negative divergent dips of the derivative of the Binder ratio (for q≥5) around these critical points. We also calculate the correlation length, the helicity modulus, and the derivative of the helicity modulus, and analyze their behaviors in different phases in detail.

Progression of liver fibrosis and associated factors among chronic hepatitis B patients at a general hospital in Northern Vietnam.

Evaluation of liver fibrosis is necessary to make the therapeutic decision and assess the prognosis of CHB patients. The current study aimed to describe the progression and identify some influencing factors in patients with chronic hepatitis B at a General Hospital in Northern Vietnam. The longitudinal study included 55 eligible subjects diagnosed Hepatitis-B-virus. Dependent variable was the aspartate aminotransferase/platelet ratio index and we collected some demographic variables and disease related and behaviour variables. Bayesian Model Averaging was used to select variables into model. Mixed-effect linear models were used to evaluate the change of the aspartate aminotransferase/platelet ratio index over time and identify related factors. the aspartate aminotransferase/platelet ratio index differences between examinations, age of participants, working status were statistically significant. This pattern indicated that the average the aspartate aminotransferase/platelet ratio index of the population decreased by 0.005 (95% CI=-0.009; -0.001) after each patient's visit, and increased by 0.013 if the patient's age increased by 1 year (95% CI=0.005; 0.0219). For non-working patients, the aspartate aminotransferase/platelet ratio index was lower, coefficient was -0.054 (95% CI=-0.108; 0.001). Other variables such as gender, education level, time for disease detection, drinking tea, alcohol consumption, forgetting to take medicine and the aspartate aminotransferase/platelet ratio index were not significantly different. The study showed that the majority of study subjects had average the aspartate aminotransferase/platelet ratio index, and were relatively well controlled and treated during the study. Age and working status are factors that influence the the aspartate aminotransferase/platelet ratio index.

Sorbent-based devices for the removal of spilled oil from water: a review.

Always, oil spills do cause serious and dire consequences for the environment, nature, and society that it consumes much time and socio-economic resources to overcome such consequences. Oil spills, hence, posed a big challenge in searching the advanced technologies and devices to recover spilled oil rapidly and efficiently. Indeed, sorbents have been found to play an extremely critical role in the spilled-oil remediation processes. Recently, a large number of various advanced sorbents and sorbent-based oil-collecting devices/technologies have been developed to enhance the oil-recovery capacity. Therefore, it is necessary to have a comprehensive assessment of the application of sorbent-based oil-collecting devices/technologies in recovering spilled oil. Due to this reason, this paper aims to provide a comprehensive review of the advanced technologies of the combination of sorbents and oil-collecting devices in the oil cleanup strategies. Two main oil-collecting devices such as booms and skimmers that could conjunct with sorbents were critically evaluated on the basis of the applicability and technological features, indicating that the capacity of oil spill recovery could achieve 90%. Moreover, oil-storage and oil-collecting devices were also completely mentioned. Last but not least, technical directions, concerns over the application of sorbents in oil recovery, and existing challenges relating to storage, transport, and disposal of used sorbents were discussed in detail. In the future, the automatic process of spilled oil recovery with the conjunction between advanced devices and environmentally friendly high-efficiency sorbents should be further investigated to minimize the environmental impacts, reduce the cost, as well as maximize the collected oil spill.

Advanced super-hydrophobic polymer-based porous absorbents for the treatment of oil-polluted water.

The threat of environmental pollution caused by spilled oil is rapidly increasing along with the expansion of oil exploration, the development of maritime activities and industrial growth. Oil spill incidents usually affect seriously the ecosystem and human life. Therefore, the treatment and recovery of the oil spill have been considered as an ultra-important issue to protect the environment and to minimize its negative impacts on socio-economic activities. Among methods of oil spill recovery, porous materials have emerged as potential absorbents possessing the capacity of absorbing spilled oil at a fast rate, high adsorption capacity, good selectivity, and high reusability. In this review paper, two types of polymer-based porous absorbents modified surface and structure were introduced for the treatment strategy of the oil-polluted water. In addition, the absorption mechanism and factors affecting the adsorption capacity for oils and organic solvents were thoroughly analyzed. More importantly, characteristics of polymer-based porous materials were discussed in detail based on microstructure analysis, absorption efficiency, and reusability. In general, this paper has provided an overview and a comprehensive assessment of the use of advanced polymer-based porous materials for the treatment of oil-polluted water, although the impacts of environmental factors such as wind, wave, and temperature should be further investigated in the future.

How has Internet Addiction been Tracked Over the Last Decade? A Literature Review and 3C Paradigm for Future Research.

BACKGROUND: The popularity of the internet aggravated by its excessive and uncontrolled use has resulted in psychological impairment or addiction. Internet addiction is hypothesized as an impulse-control disorder of internet use having detrimental impacts on daily life functions, family relationships, and emotional stability. The goal of this review is to provide an exhaustive overview of the empirical evidence on internet addiction and draw attention to future research themes. METHODS: We performed a literature search on ScienceDirect and PubMed to review original research articles with empirical evidence published on peer-reviewed international journals from 2010 to 2019. Eight hundred and 26 articles were eligible for analysis. Frequency and descriptive statistics were calculated by Microsoft Excel. RESULTS: A substantial contribution has been coming from researchers from China, Turkey, Korea, Germany, and Taiwan respectively. Despite controversies regarding its definition and diagnostic procedures, internet addiction has become the focal point of a myriad of studies that investigated this particular phenomenon from different exposures. Given observed literature review data regarding research design, data acquisition, and data analysis strategies, we proposed the 3C paradigm which emphasizes the necessity of research incorporating cross-disciplinary investigation conducted on cross-cultural settings with conscientious cross-validation considerations to gain a better comprehension of internet addiction. CONCLUSIONS: The findings of the present literature review will serve both academics and practitioners to develop new solutions for better characterize internet addiction.

Auxiliary-directed etherification of sp2 C-H bonds under heterogeneous metal-organic framework catalysis: synthesis of ethenzamide.

An efficient protocol for 8-aminoquinoline assisted alkoxylation and phenoxylation of sp2 C-H bonds under heterogeneous catalysis was developed. The optimal conditions employed Cu-MOF-74 (20%), K2CO3 base, pyridine ligand or dimethyl formamide solvent, and O2 oxidant at 80 °C or 100 °C for 24 hours. Cu-MOF-74 revealed remarkably higher activity when compared with other previously commonly used Cu-MOFs in cross coupling reactions, supported copper catalysts, and homogeneous copper salts. The reaction scope with respect to coupling partners included a wide range of various substrates. Interestingly, the developed conditions are applicable for the synthesis of high-profile relevant biological agents from easily accessible starting materials. Furthermore, a leaching test confirmed the reaction heterogeneity and the catalyst was reused and recycled at least 8 times with trivial degradation in activity.