1.
Ann N Y Acad Sci
; 987: 60-7, 2003 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12727624
RESUMO
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by loss of T cell tolerance to nuclear antigens. Studies in mice and humans have demonstrated that T cells from individuals with lupus are abnormal. Here, we review the known T cell defects in lupus and their possible biochemical nature, genetic causes, and significance for lupus pathogenesis.