Detalhe da pesquisa
1.
Inhibition of the BTK-IDO-mTOR axis promotes differentiation of monocyte-lineage dendritic cells and enhances anti-tumor T cell immunity.
Immunity
; 54(10): 2354-2371.e8, 2021 10 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34614413
2.
The new small tyrosine kinase inhibitor ARQ531 targets acute myeloid leukemia cells by disrupting multiple tumor-addicted programs.
Haematologica
; 105(10): 2420-2431, 2020 10 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33054082
3.
In-vitro and in-vivo combined effect of ARQ 092, an AKT inhibitor, with ARQ 087, a FGFR inhibitor.
Anticancer Drugs
; 28(5): 503-513, 2017 06.
Artigo
Inglês
| MEDLINE | ID: mdl-28240679
4.
First-in-Human Study of the Reversible BTK Inhibitor Nemtabrutinib in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia and B-Cell Non-Hodgkin Lymphoma.
Cancer Discov
; 14(1): 66-75, 2024 01 12.
Artigo
Inglês
| MEDLINE | ID: mdl-37930156
5.
Structural basis for Rab GTPase recognition and endosome tethering by the C2H2 zinc finger of Early Endosomal Autoantigen 1 (EEA1).
Proc Natl Acad Sci U S A
; 107(24): 10866-71, 2010 Jun 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20534488
6.
Discovery of a novel mode of protein kinase inhibition characterized by the mechanism of inhibition of human mesenchymal-epithelial transition factor (c-Met) protein autophosphorylation by ARQ 197.
J Biol Chem
; 286(23): 20666-76, 2011 Jun 10.
Artigo
Inglês
| MEDLINE | ID: mdl-21454604
7.
A novel mode of protein kinase inhibition exploiting hydrophobic motifs of autoinhibited kinases: discovery of ATP-independent inhibitors of fibroblast growth factor receptor.
J Biol Chem
; 286(23): 20677-87, 2011 Jun 10.
Artigo
Inglês
| MEDLINE | ID: mdl-21454610
8.
TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism.
Nature
; 442(7100): 303-6, 2006 Jul 20.
Artigo
Inglês
| MEDLINE | ID: mdl-16855591
9.
Preclinical evaluation of combination nemtabrutinib and venetoclax in chronic lymphocytic leukemia.
J Hematol Oncol
; 15(1): 166, 2022 11 15.
Artigo
Inglês
| MEDLINE | ID: mdl-36380319
10.
Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
Nature
; 436(7049): 415-9, 2005 Jul 21.
Artigo
Inglês
| MEDLINE | ID: mdl-16034420
11.
Preclinical efficacy for a novel tyrosine kinase inhibitor, ArQule 531 against acute myeloid leukemia.
J Hematol Oncol
; 13(1): 8, 2020 01 28.
Artigo
Inglês
| MEDLINE | ID: mdl-31992353
12.
ESCRT complexes assembled and GLUEd.
Structure
; 14(4): 631-2, 2006 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-16615903
13.
The BTK Inhibitor ARQ 531 Targets Ibrutinib-Resistant CLL and Richter Transformation.
Cancer Discov
; 8(10): 1300-1315, 2018 10.
Artigo
Inglês
| MEDLINE | ID: mdl-30093506
14.
Structural basis for Rab11-mediated recruitment of FIP3 to recycling endosomes.
J Mol Biol
; 364(2): 121-35, 2006 Nov 24.
Artigo
Inglês
| MEDLINE | ID: mdl-17007872
15.
Preclinical Activity of ARQ 087, a Novel Inhibitor Targeting FGFR Dysregulation.
PLoS One
; 11(9): e0162594, 2016.
Artigo
Inglês
| MEDLINE | ID: mdl-27627808
16.
Discovery of 3-(3-(4-(1-Aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine (ARQ 092): An Orally Bioavailable, Selective, and Potent Allosteric AKT Inhibitor.
J Med Chem
; 59(13): 6455-69, 2016 07 14.
Artigo
Inglês
| MEDLINE | ID: mdl-27305487
17.
Targeting AKT1-E17K and the PI3K/AKT Pathway with an Allosteric AKT Inhibitor, ARQ 092.
PLoS One
; 10(10): e0140479, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-26469692
18.
Discovery and optimization of a series of 3-(3-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amines: orally bioavailable, selective, and potent ATP-independent Akt inhibitors.
J Med Chem
; 55(11): 5291-310, 2012 Jun 14.
Artigo
Inglês
| MEDLINE | ID: mdl-22533986
19.
Determinants of Rab5 interaction with the N terminus of early endosome antigen 1.
J Biol Chem
; 278(10): 8494-500, 2003 Mar 07.
Artigo
Inglês
| MEDLINE | ID: mdl-12493736