Prevalencia de virus del papiloma humano en mujeres españolas de un programa de cribado poblacional / Prevalence of human papillomavirus in Spanish women from a population screening program

Introducción. El virus del papiloma humano (VPH), es causa necesaria para el desarrollo de cáncer de cuello uterino. El objetivo del estudio fue estimar la prevalencia de mujeres con infección por VPH, adheridas al Programa de Prevención y Detección precoz de Cáncer de cuello de útero de Castilla y León (España). Material y métodos. Se han evaluado los resultados del análisis de VPH en las muestras de las mujeres incluidas en el programa de cribado poblacional. El estudio incluye un total de 120.326 muestras de frotis de cérvix, recogidas en el periodo comprendido entre enero de 2012 y diciembre de 2014. Resultados. Se obtuvieron 12.183 muestras con detección positiva de ADN de VPH, correspondiendo a una prevalencia de 9,6‰ (IC 95% 9,5%-9,8%), en la población femenina. Los VPH asociados a un alto riesgo de transformación celular se encuentran en mayor proporción que los de bajo riesgo (5,9% vs 2,23%). La prevalencia está inversamente relacionada con la edad de las mujeres del cribado. La presencia de infecciones múltiples de VPH se demuestra en un tercio de las mujeres analizadas. Conclusiones. Estos resultados son los primeros y más amplios de un programa de cribado poblacional estructurado en España y deben servir como referencia para futuros estudios y medir el impacto futuro de la vacunación (AU)

Introduction. The human papillomavirus (HPV), is necessary to cause a woman developing cervical cancer. The aim of the study was to estimate the prevalence of women with HPV infection, covered by the program of prevention and early detection of cervical cancer of Castile and León (Spain). Material and methods. Samples of women included in the screening program were analyzed. Including a total of 120,326 cervical swab samples, collected in the period from January 2012 to December 2014. Results. 12,183 HPV positive samples were detected, representing a prevalence of 9.6 ‰, (IC 95% 9.5%-9.8%) in the female population. High-risk HPV were found in higher proportion that HPV low-risk genotypes. HPV prevalence correlates inversely with women age. Coinfections of multiple genotypes were found in one third of screened women population. Conclusions. Data showed in this study are the first and wider Spanish results from a cervical cancer screening program population non opportunistic based on HPV detection. These results would serve as a reference for future prevalence studies and to evaluate the future impact of HPV vaccination campaigns (AU)

A type-specific study of human papillomavirus prevalence in cervicovaginal samples in three different Spanish regions.

Human papillomavirus (HPV) is the most frequent sexually transmitted viral infection. It is necessary to know HPV genotype distribution to identify how many women will be protected by HPV vaccines. During a period of 18 months, we have analyzed 2362 HPV positive reporting data from a secondary demand screening program in three regions in Spain (Cantabria, Leon and Burgos). The study has been conducted using polymerase chain reaction and tube array hybridization covering the 35 HPV genotypes described as affecting anogenital mucosa. There were no significant differences between the three regions according to genotype distribution. The most frequent were HPV16 (19.18%), HPV53 (11.26%) and HPV58 (7.66%). HPV18 was the source of 4.02% of infections. High-risk HPVs were found in 1863/2362 cases. HPV16 was present in 24.3% of high-risk infections and HPV18 was found in 5.1%. Uncommon genotypes (<5% of the total prevalence each) were found in 17,9% of the total high-risk infections (334/1863). Multiple infections were diagnosed in 22% of the cases. The HPV genotype distribution is different from previously published data when multiple types are included in the screening. Both HPV16/18 account for 30% of high-risk infections in a clinical setting in Spain. The presence of multiple genotypes is very common among the population.

Erupción papulosa liquenoide / Papular lichenoid eruption

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