Detalhe da pesquisa
1.
Nationwide randomised trial evaluating elective neck dissection for early stage oral cancer (SEND study) with meta-analysis and concurrent real-world cohort.
Br J Cancer
; 121(10): 827-836, 2019 11.
Artigo
Inglês
| MEDLINE | ID: mdl-31611612
2.
5-Substituted-N-pyridazinylbenzamides as potent and selective LRRK2 inhibitors: Improved brain unbound fraction enables efficacy.
Bioorg Med Chem Lett
; 29(2): 212-215, 2019 01 15.
Artigo
Inglês
| MEDLINE | ID: mdl-30522952
3.
Discovery of 4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-amines as potent, selective and orally bioavailable LRRK2 inhibitors.
Bioorg Med Chem Lett
; 28(9): 1615-1620, 2018 05 15.
Artigo
Inglês
| MEDLINE | ID: mdl-29588215
4.
Accelerating molecular discovery through data and physical sciences: Applications to peptide-membrane interactions.
J Chem Phys
; 148(24): 241744, 2018 Jun 28.
Artigo
Inglês
| MEDLINE | ID: mdl-29960328
5.
Correction to: Nationwide randomised trial evaluating elective neck dissection for early stage oral cancer (SEND study) with meta-analysis and concurrent real-world cohort.
Br J Cancer
; 126(5): 831, 2022 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-34949789
6.
Discovery of 5-substituent-N-arylbenzamide derivatives as potent, selective and orally bioavailable LRRK2 inhibitors.
Bioorg Med Chem Lett
; 27(17): 4034-4038, 2017 09 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28774425
7.
Latonduine Analogs Restore F508del-Cystic Fibrosis Transmembrane Conductance Regulator Trafficking through the Modulation of Poly-ADP Ribose Polymerase 3 and Poly-ADP Ribose Polymerase 16 Activity.
Mol Pharmacol
; 90(2): 65-79, 2016 08.
Artigo
Inglês
| MEDLINE | ID: mdl-27193581
8.
A Concise Enantioselective Synthesis of Fluorinated Pyrazolo-Piperidine GSK3901383A Enabled by an Organocatalytic Aza-Michael Addition.
Org Lett
; 26(8): 1533-1538, 2024 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-38363757
9.
Synthesis of 2,6-trans-Tetrahydropyrans Using a Palladium-Catalyzed Oxidative Heck Redox-Relay Strategy.
Org Lett
; 26(14): 2857-2861, 2024 Apr 12.
Artigo
Inglês
| MEDLINE | ID: mdl-38198695
10.
Synthesis and evaluation of novel alpha-amino cyclic boronates as inhibitors of HCV NS3 protease.
Bioorg Med Chem Lett
; 20(12): 3550-6, 2010 Jun 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20493689
11.
Assessment of nonequilibrium free energy methods.
J Phys Chem B
; 113(16): 5508-19, 2009 Apr 23.
Artigo
Inglês
| MEDLINE | ID: mdl-19368411
12.
Protein-ligand binding affinity by nonequilibrium free energy methods.
J Phys Chem B
; 112(47): 14985-92, 2008 Nov 27.
Artigo
Inglês
| MEDLINE | ID: mdl-18973369
13.
Getting the chemistry right: protonation, tautomers and the importance of H atoms in biological chemistry.
Acta Crystallogr D Struct Biol
; 73(Pt 2): 131-140, 2017 02 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28177309
14.
New Insights into the Catalytic Mechanism of Aldose Reductase: A QM/MM Study.
ACS Omega
; 2(9): 5737-5747, 2017 Sep 30.
Artigo
Inglês
| MEDLINE | ID: mdl-30023751
15.
A Perspective on Water Site Prediction Methods for Structure Based Drug Design.
Curr Top Med Chem
; 17(23): 2599-2616, 2017.
Artigo
Inglês
| MEDLINE | ID: mdl-28460610
16.
Decorating Self-Assembled Peptide Cages with Proteins.
ACS Nano
; 11(8): 7901-7914, 2017 08 22.
Artigo
Inglês
| MEDLINE | ID: mdl-28686416
17.
A High-Throughput Screen to Identify LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease Using RapidFire Mass Spectrometry.
J Biomol Screen
; 21(2): 145-55, 2016 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-26403521
18.
Crystallizing Membrane Proteins in the Lipidic Mesophase. Experience with Human Prostaglandin E2 Synthase 1 and an Evolving Strategy.
Cryst Growth Des
; 14(4): 2034-2047, 2014 Apr 02.
Artigo
Inglês
| MEDLINE | ID: mdl-24803849
19.
Lead discovery for microsomal prostaglandin E synthase using a combination of high-throughput fluorescent-based assays and RapidFire mass spectrometry.
J Biomol Screen
; 17(5): 641-50, 2012 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-22337655
20.
Parametrization of Reversible Digitally Filtered Molecular Dynamics Simulations.
J Chem Theory Comput
; 1(1): 24-35, 2005 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-26641112