Detalhe da pesquisa
1.
Soluble epoxide hydrolase inhibition does not prevent cardiac remodeling and dysfunction after aortic constriction in rats and mice.
J Cardiovasc Pharmacol
; 61(4): 291-301, 2013 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-23232840
2.
Perspective on high-throughput bioanalysis to support in vitro assays in early drug discovery.
Bioanalysis
; 15(3): 177-191, 2023 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-36917553
3.
Design and synthesis of polyethylene glycol-modified biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s.
Bioorg Med Chem Lett
; 22(16): 5303-7, 2012 Aug 15.
Artigo
Inglês
| MEDLINE | ID: mdl-22795627
4.
The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs.
Sci Transl Med
; 11(496)2019 06 12.
Artigo
Inglês
| MEDLINE | ID: mdl-31189717
5.
Orally efficacious thrombin inhibitors with cyanofluorophenylacetamide as the P2 motif.
Bioorg Med Chem Lett
; 18(9): 2865-70, 2008 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-18420408
6.
Design and Optimization of Sulfone Pyrrolidine Sulfonamide Antagonists of Transient Receptor Potential Vanilloid-4 with in Vivo Activity in a Pulmonary Edema Model.
J Med Chem
; 61(24): 11209-11220, 2018 12 27.
Artigo
Inglês
| MEDLINE | ID: mdl-30500190
7.
Activation of the Amino Acid Response Pathway Blunts the Effects of Cardiac Stress.
J Am Heart Assoc
; 6(5)2017 May 09.
Artigo
Inglês
| MEDLINE | ID: mdl-28487390
8.
Design, synthesis, and biological evaluation of novel potent and selective alphavbeta3/alphavbeta5 integrin dual inhibitors with improved bioavailability. Selection of the molecular core.
J Med Chem
; 48(4): 926-34, 2005 Feb 24.
Artigo
Inglês
| MEDLINE | ID: mdl-15715463
9.
A functional radioreceptor assay of alpha-V-beta-3 (alphavbeta3) inhibitors in plasma: application as an ex vivo pharmacodynamic model.
J Biochem Biophys Methods
; 65(2-3): 107-20, 2005 Dec 31.
Artigo
Inglês
| MEDLINE | ID: mdl-16325916
10.
Soluble epoxide hydrolase inhibition exerts beneficial anti-remodeling actions post-myocardial infarction.
Int J Cardiol
; 167(1): 210-9, 2013 Jul 15.
Artigo
Inglês
| MEDLINE | ID: mdl-22236509
11.
Voltage-gated Na+ channel blockers reduce functional bladder capacity in the conscious spontaneously hypertensive rat.
Urology
; 79(6): 1410.e1-6, 2012 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-22497980
12.
Pharmacokinetic properties of TDP4815 after single intravenous and oral administrations to rat, rabbit, monkey, dog and in vitro drug metabolism.
Biopharm Drug Dispos
; 29(3): 127-38, 2008 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-18186144
13.
Oxyguanidines: application to non-peptidic phenyl-based thrombin inhibitors.
Bioorg Med Chem Lett
; 13(8): 1495-8, 2003 Apr 17.
Artigo
Inglês
| MEDLINE | ID: mdl-12668020
14.
Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis.
Bioorg Med Chem Lett
; 14(14): 3727-31, 2004 Jul 16.
Artigo
Inglês
| MEDLINE | ID: mdl-15203151