Detalhe da pesquisa
1.
Repurposed dihydroorotate dehydrogenase inhibitors with efficacy against drug-resistant Acinetobacter baumannii.
Proc Natl Acad Sci U S A
; 119(51): e2213116119, 2022 12 20.
Artigo
Inglês
| MEDLINE | ID: mdl-36512492
2.
Identification of New Human Malaria Parasite Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors by Pharmacophore and Structure-Based Virtual Screening.
J Chem Inf Model
; 56(3): 548-62, 2016 Mar 28.
Artigo
Inglês
| MEDLINE | ID: mdl-26915022
3.
Chemical genetics of Plasmodium falciparum.
Nature
; 465(7296): 311-5, 2010 May 20.
Artigo
Inglês
| MEDLINE | ID: mdl-20485428
4.
Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series.
J Med Chem
; 64(9): 6085-6136, 2021 05 13.
Artigo
Inglês
| MEDLINE | ID: mdl-33876936
5.
Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds.
J Biol Chem
; 284(39): 26999-7009, 2009 Sep 25.
Artigo
Inglês
| MEDLINE | ID: mdl-19640844
6.
Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria.
J Med Chem
; 63(9): 4929-4956, 2020 05 14.
Artigo
Inglês
| MEDLINE | ID: mdl-32248693
7.
Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265.
ACS Infect Dis
; 5(1): 90-101, 2019 01 11.
Artigo
Inglês
| MEDLINE | ID: mdl-30375858
8.
Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum.
J Med Chem
; 51(12): 3649-53, 2008 Jun 26.
Artigo
Inglês
| MEDLINE | ID: mdl-18522386
9.
Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity.
ACS Omega
; 3(8): 9227-9240, 2018 Aug 31.
Artigo
Inglês
| MEDLINE | ID: mdl-30197997
10.
Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity.
J Med Chem
; 59(11): 5416-31, 2016 06 09.
Artigo
Inglês
| MEDLINE | ID: mdl-27127993
11.
A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria.
ACS Infect Dis
; 2(12): 945-957, 2016 12 09.
Artigo
Inglês
| MEDLINE | ID: mdl-27641613
12.
Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH).
J Med Chem
; 58(14): 5579-98, 2015 Jul 23.
Artigo
Inglês
| MEDLINE | ID: mdl-26079043
13.
A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria.
Sci Transl Med
; 7(296): 296ra111, 2015 Jul 15.
Artigo
Inglês
| MEDLINE | ID: mdl-26180101
14.
Fluorine modulates species selectivity in the triazolopyrimidine class of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors.
J Med Chem
; 57(12): 5381-94, 2014 Jun 26.
Artigo
Inglês
| MEDLINE | ID: mdl-24801997
15.
Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase.
J Med Chem
; 55(17): 7425-36, 2012 Sep 13.
Artigo
Inglês
| MEDLINE | ID: mdl-22877245
16.
Lead optimization of 3-carboxyl-4(1H)-quinolones to deliver orally bioavailable antimalarials.
J Med Chem
; 55(9): 4205-19, 2012 May 10.
Artigo
Inglês
| MEDLINE | ID: mdl-22435599
17.
Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice.
J Med Chem
; 54(11): 3935-49, 2011 Jun 09.
Artigo
Inglês
| MEDLINE | ID: mdl-21517059
18.
Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential.
J Med Chem
; 54(15): 5540-61, 2011 Aug 11.
Artigo
Inglês
| MEDLINE | ID: mdl-21696174
19.
Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice.
J Med Chem
; 52(7): 1864-72, 2009 Apr 09.
Artigo
Inglês
| MEDLINE | ID: mdl-19296651