1.
Bull Exp Biol Med
; 150(5): 632-4, 2011 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22235402
RESUMO
We performed quantitative analysis of FOSL1 gene expression in lesional psoriatic skin. The expression of this gene in lesional psoriatic skin was significantly increased compared to that in unaffected areas. Enhanced FOSL1 expression significantly correlated with high psoriasis area and severity index (PASI). High level of FOSL1 gene expression was proposed to be a marker of pathological process activity in psoriasis.
Assuntos
Proteínas Proto-Oncogênicas c-fos/metabolismo , Psoríase/genética , Psoríase/patologia , Pele/patologia , Fator de Transcrição AP-1/metabolismo , Humanos , RNA Mensageiro/genética , RNA Mensageiro/metabolismo , Pele/metabolismo
2.
Genetika
; 46(1): 104-10, 2010 Jan.
Artigo
em Russo
| MEDLINE
| ID: mdl-20198886
RESUMO
Psoriatic and atherosclerotic plaques were examined using the real-time polymerase chain reaction. Expression of the FOSL1 gene proved to substantially increase in both psoriatic lesions of the skin and atherosclerotic lesions of vessels as compared with nonlesion samples.