RESUMO
Cystic Fibrosis (CF) is the most common autosomal-recessive genetic disease affecting approximately 8000 people in Germany. The disease is caused by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene leading to dysfunction of CFTR, a transmembrane chloride channel. This defect causes insufficient hydration of the epithelial lining fluid which leads to chronic inflammation of the airways. Recurrent infections of the airways as well as pulmonary exacerbations aggravate chronic inflammation, lead to pulmonary fibrosis and tissue destruction up to global respiratory insufficiency, which is responsible for the mortality in over 90â% of patients. The main aim of pulmonary treatment in CF is to reduce pulmonary inflammation and chronic infection. Pseudomonas aeruginosa (Pa) is the most relevant pathogen in the course of CF lung disease. Colonization and chronic infection are leading to additional loss of pulmonary function. There are many possibilities to treat Pa-infection. This is a S3-clinical guideline which implements a definition for chronic Pa-infection and demonstrates evidence-based diagnostic methods and medical treatment for Pa-infection in order to give guidance for individual treatment options.
Assuntos
Regulador de Condutância Transmembrana em Fibrose Cística/genética , Fibrose Cística/diagnóstico , Fibrose Cística/terapia , Guias de Prática Clínica como Assunto , Pseudomonas aeruginosa/isolamento & purificação , Fibrose Cística/complicações , Fibrose Cística/microbiologia , Regulador de Condutância Transmembrana em Fibrose Cística/metabolismo , Alemanha , Humanos , Infecções por Pseudomonas/diagnósticoRESUMO
BACKGROUND: Cystic fibrosis (CF) is a chronic, life-shortening disease of multiple organ systems. Guidelines recommend that patients should be treated in specialised CF centres with multi-professional teams. We describe the organisation of medical care at the CF centre of Innsbruck University as well as results of treatment. PATIENTS AND METHODS: Procedures and delivery of multi-professional care have been elaborated and structured. Since 2006 the Centre has been repeatedly certified according to DIN ISO 9001:2000. The patient database is being used during the doctor's consultation and for the continuous monitoring of treatment results. RESULTS: In 2010, 71 of the 148 patients (48%) were between 18 and 56 years old. The total number of patients has doubled and the proportion of adults tripled since 1995. Nevertheless, median FEV1 remained stable (>80% of predicted) during the last 15 years. Compared with 18 CF centres of the German Benchmarking Group, patients treated in Innsbruck had favourable FEV1 values: 52% of adults had a normal FEV1 (>80% pred.) and only 23% an FEV1 <50% of predicted. CONCLUSIONS: A structured programme of multi-professional care was associated with favourable treatment results, both longitudinally and in comparison to other CF centres.
Assuntos
Certificação/organização & administração , Comportamento Cooperativo , Fibrose Cística/reabilitação , Hospitais Especializados/organização & administração , Comunicação Interdisciplinar , Equipe de Assistência ao Paciente/organização & administração , Adolescente , Adulto , Áustria , Benchmarking/organização & administração , Estudos Transversais , Fibrose Cística/diagnóstico , Fibrose Cística/epidemiologia , Fibrose Cística/fisiopatologia , Feminino , Seguimentos , Volume Expiratório Forçado/fisiologia , Hospitais Universitários , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Adulto JovemRESUMO
To investigate the impact of chloride (Cl(-)) permeability, mediated by residual activity of the cystic fibrosis transmembrane conductance regulator (CFTR) or by other Cl(-) channels, on the manifestations of cystic fibrosis (CF), we determined Cl(-) transport properties of the respiratory and intestinal tracts in Delta F508 homozygous twins and siblings. In the majority of patients, cAMP and/or Ca(2+)-regulated Cl(-) conductance was detected in the airways and intestine. Our finding of cAMP-mediated Cl(-) conductance suggests that, in vivo, at least some Delta F508 CFTR can reach the plasma membrane and affect Cl(-) permeability. In respiratory tissue, the expression of basal CFTR-mediated Cl(-) conductance, demonstrated by 30% of Delta F508 homozygotes, was identified as a positive predictor of milder CF disease. In intestinal tissue, 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid-insensitive (DIDS-insensitive) Cl(-) secretion, which is indicative of functional CFTR channels, correlated with a milder phenotype, whereas DIDS-sensitive Cl(-) secretion was observed mainly in more severely affected patients. The more concordant Cl(-) secretory patterns within monozygous twins compared with dizygous pairs imply that genes other than CFTR significantly influence the manifestation of the basic defect.
Assuntos
Cloretos/metabolismo , Regulador de Condutância Transmembrana em Fibrose Cística/genética , Fibrose Cística/genética , Doenças em Gêmeos , Adolescente , Adulto , Criança , Fibrose Cística/metabolismo , Feminino , Homozigoto , Humanos , Masculino , FenótipoRESUMO
[This corrects the article DOI: 10.1155/2014/621342.].
RESUMO
Antioxidants such as vitamin E protect unsaturated fatty acids of LDL against oxidation. In the ex vivo model used, LDL was exposed to Cu2+ ions, a potent prooxidant capable of initiating the oxidation of LDL. The lag time, indicating the delay of conjugated diene formation in LDL due to antioxidant protection, was measured in 54 cystic fibrosis (CF) patients with plasma alpha-tocopherol levels below (Group A, n = 30) or above (Group B, n = 24) 15.9 mumol/L (mean - 2 SD of Swiss population). Patients were reevaluated after 2 months on 400 IU/d of oral RRR-alpha-tocopherol. In group A, alpha-tocopherol concentrations in LDL increased significantly from 3.2 +/- 1.6 mol/mol LDL to 8.2 +/- 2.8 mol/mol (P < 0.001) and lag times increased from 79 +/- 33 min to 126 +/- 48 min (P < 0.001), whereas in the vitamin E sufficient group B no further increase neither in LDL alpha-tocopherol concentrations or in lag times was observed. LDL oleic acid concentrations were higher, and linoleic acid concentrations were lower in patients than in controls. After efficient vitamin E supplementation, lag times were positively related to LDL alpha-tocopherol (P < 0.01) and negatively to LDL linoleic and arachidonic acid content (P < 0.001). The maximum rate of oxidation correlated positively with linoleic and arachidonic acid concentrations, as did the maximum conjugated diene absorbance. These results indicate that LDL resistance to oxidation is impaired in vitamin E deficient CF patients but can be normalized within 2 months when alpha-tocopherol is given in sufficient amounts. Linoleic and arachidonic acid content exhibit a major influence on the LDL resistance to oxidation.
Assuntos
Antioxidantes/administração & dosagem , Fibrose Cística/metabolismo , Peroxidação de Lipídeos/efeitos dos fármacos , Lipoproteínas LDL/metabolismo , Vitamina E/administração & dosagem , Adulto , Cobre/farmacologia , Fibrose Cística/complicações , Ácidos Graxos/sangue , Humanos , Oxirredução , Vitamina E/sangue , Vitamina E/uso terapêutico , Deficiência de Vitamina E/complicações , Deficiência de Vitamina E/tratamento farmacológicoRESUMO
Vitamin C status and possible associations with the disease process in cystic fibrosis (CF) patients were investigated. Plasma vitamin C concentrations in patients from two different mid-European populations (Swiss, n = 62; Austrian, n = 60) taking no or low-dose vitamin C from multivitamin supplements did not differ from each other or from control subjects (n = 34). Vitamin C concentrations decreased with age (5.05 mumol.L-1, y-1). When followed up for 12 mo, patients had the highest plasma vitamin C concentrations in February and the lowest in May and August (P < 0.01); the decrease in vitamin C was accompanied by increases in plasma malondialdehyde (P < 0.001) and tumor necrosis factor alpha concentrations (P < 0.01). During supplementation with vitamin E for 2 mo or beta-carotene for 12 mo vitamin C concentrations did not change. They correlated inversely with white blood cell count (r = -0.36, P = 0.008), bands (r = -0.36, P = 0.02), alpha 1-acid glycoprotein (r = -0.45, P = 0.002), interleukin 6 (r = -0.46, P = 0.0006), and neutrophil elastase/alpha 1-proteinase inhibitor complexes (r = -0.34, P = 0.02). In patients with vitamin C concentrations < 40 mumol/L, all indexes of inflammation were relatively high, whereas those with concentrations > 80 mumol/L (upper quartile of control subjects) showed clearly lower values. These results are consistent with the hypothesis that by scavenging oxygen free radicals vitamin C interacts with an inflammation-amplifying cycle of activation of alveolar macrophages and neutrophils, release of proinflammatory cytokines and oxygen free radicals, and inactivation of antiproteases.
Assuntos
Ácido Ascórbico/sangue , Fibrose Cística/sangue , Pneumopatias/sangue , Adolescente , Adulto , Criança , Pré-Escolar , Estudos de Coortes , Fibrose Cística/etiologia , Fibrose Cística/fisiopatologia , Citocinas/metabolismo , Relação Dose-Resposta a Droga , Feminino , Humanos , Lactente , Inflamação/sangue , Inflamação/etiologia , Inflamação/fisiopatologia , Interleucina-6/sangue , Elastase de Leucócito/sangue , Peroxidação de Lipídeos/fisiologia , Pneumopatias/etiologia , Pneumopatias/fisiopatologia , Masculino , Malondialdeído/sangue , Estado Nutricional , Orosomucoide/análise , Orosomucoide/metabolismo , Estações do Ano , Fator de Necrose Tumoral alfa/análise , Fator de Necrose Tumoral alfa/metabolismo , Vitamina E/administração & dosagem , Vitamina E/farmacologia , beta Caroteno/administração & dosagem , beta Caroteno/sangue , beta Caroteno/farmacologiaRESUMO
AIM: To evaluate the use of intraosseous lines for rapid vascular access in primary resuscitation of preterm and full term neonates. METHODS: Thirty intraosseous lines were placed in 27 newborns, in whom conventional venous access had failed. RESULTS: All the neonates survived the resuscitation procedure, with no long term side effects. CONCLUSION: Intraosseous infusion is quick, safe, and effective in compromised neonates.
Assuntos
Hidratação , Doenças do Prematuro/terapia , Infusões Intraósseas/métodos , Ressuscitação , Asfixia Neonatal/tratamento farmacológico , Asfixia Neonatal/terapia , Contraindicações , Estudos de Avaliação como Assunto , Feminino , Cardiopatias Congênitas/terapia , Humanos , Recém-Nascido , Recém-Nascido Prematuro , Doenças do Prematuro/tratamento farmacológico , Masculino , Síndrome do Desconforto Respiratório do Recém-Nascido/tratamento farmacológico , Síndrome do Desconforto Respiratório do Recém-Nascido/terapia , TíbiaRESUMO
An enzyme immunoassay kit for the determination of anti-gliadin-IgA antibodies in serum has been evaluated in the diagnosis of coeliac disease in childhood. 84 patients, 22 of them with coeliac disease according to ESPGAN's criteria were tested between 1978 and 1989 and the results have been correlated with the findings on small intestine biopsy and the clinical features. The sensitivity of the test was 95.5% and the specificity was 87.0% on initial diagnosis. On a gluten-free diet reduced antibody levels were seen in all patients. During gluten challenge 11 of 13 children showed an increase in anti-gliadin-IgA concentration. Of the remaining 2 without antibody elevation IgA deficiency became manifest in one patient, the other had a nearly normal mucosa on small intestine biopsy. Provided that IgA deficiency is ruled out and the gluten intake is sufficient the test seems to be useful for screening and might replace biopsy after gluten challenge in cases of increasing antibody levels.
Assuntos
Doença Celíaca/diagnóstico , Gliadina/imunologia , Imunoglobulina A/análise , Biópsia , Doença Celíaca/dietoterapia , Doença Celíaca/imunologia , Criança , Pré-Escolar , Gliadina/administração & dosagem , Glutens/administração & dosagem , Humanos , Técnicas Imunoenzimáticas , Lactente , Mucosa Intestinal/patologiaRESUMO
Up to now 49,116 immunoreactive trypsin (IRT) measurements have been carried out in Austrian newborns in the first week of life. Related to provisionally chosen cut-off points, 301 newborns (0.61%) showed an elevated IRT value; 253 of them were successfully recalled. According to a direct strategy, sweat tests were done without a second IRT measurement in 101 infants; eleven of them were identified as cystic fibrosis (CF) patients. In accordance with a 2-step strategy, 152 infants were reinvestigated by a second IRT determination. Twenty-eight of them again showed an elevated IRT value, as based on provisional, age-dependent reference values; seven were subsequently identified as CF patients by sweat testing. So far two false-negative findings were obtained on IRT screening: one child was later identified as having CF on the basis of typical clinical symptoms and a positive sweat test, the other patient presenting with meconium ileus showed a normal IRT value after surgery, but was subjected to a sweat test in view of the underlying condition. These preliminary results suggest a CF incidence of 1 to 2460 newborns in Austria. Hence, IRT screening appears to be a reliable method for identifying CF patients in the newborn period, thereby facilitating early treatment and genetic counselling.
Assuntos
Fibrose Cística/prevenção & controle , Triagem Neonatal , Radioimunoensaio , Tripsina/sangue , Áustria , Fibrose Cística/diagnóstico , Humanos , Recém-Nascido , Valor Preditivo dos Testes , Valores de ReferênciaRESUMO
There are no European recommendations on issues specifically related to lung transplantation (LTX) in cystic fibrosis (CF). The main goal of this paper is to provide CF care team members with clinically relevant CF-specific information on all aspects of LTX, highlighting areas of consensus and controversy throughout Europe. Bilateral lung transplantation has been shown to be an important therapeutic option for end-stage CF pulmonary disease. Transplant function and patient survival after transplantation are better than in most other indications for this procedure. Attention though has to be paid to pretransplant morbidity, time for referral, evaluation, indication, and contraindication in children and in adults. This review makes extensive use of specific evidence in the field of lung transplantation in CF patients and addresses all issues of practical importance. The requirements of pre-, peri-, and postoperative management are discussed in detail including bridging to transplant and postoperative complications, immune suppression, chronic allograft dysfunction, infection, and malignancies being the most important. Among the contributors to this guiding information are 19 members of the ECORN-CF project and other experts. The document is endorsed by the European Cystic Fibrosis Society and sponsored by the Christiane Herzog Foundation.
Assuntos
Fibrose Cística/cirurgia , Transplante de Pulmão/normas , Contraindicações , Circulação Extracorpórea/normas , Rejeição de Enxerto/prevenção & controle , Humanos , Transplante de Pulmão/efeitos adversos , Transplante de Pulmão/métodos , Terapia Nutricional/normas , Educação de Pacientes como Assunto , Cuidados Pós-Operatórios/normas , Cuidados Pré-Operatórios/normas , Psicologia , Apoio Social , Obtenção de Tecidos e Órgãos/organização & administraçãoRESUMO
The "team-approach" in the care of chronically ill children is one way of interdisciplinary cooperation. The care of CF-patients requires the coordination of all treatment-measures and the integration of psychosocial counselling and management into medical treatment. Not only emotionally straining situations--"telling" the diagnosis, non-compliance, care of terminally ill patients--have to be managed, but both, illness and treatment, produce a lot of problems, to which solutions have to be offered. The task of psychological staff is on the one hand to contribute their specific knowledge to treatment-concepts, to enhance the psychosocial competence of the medical staff and, on the other hand, to offer counselling to the patients and their parents.
Assuntos
Adaptação Psicológica , Fibrose Cística/psicologia , Equipe de Assistência ao Paciente , Psicoterapia , Papel do Doente , Adolescente , Criança , Terapia Combinada , Fibrose Cística/reabilitação , Terapia Familiar , HumanosRESUMO
Members of the lipocalin protein family are characterized by their ability to bind small hydrophobic molecules. Some of them are known to be produced by various glands and secretory cells. Under certain conditions, these proteins would be ideally suited for clearance of lipophilic, potentially harmful substances and might also act as protection factors in airway secretions. We therefore used RT-PCR analysis with a set of oligonucleotide primers deduced from conserved regions of lipocalin members to identify specific RNA isolated from human trachea. With two of these oligonucleotide primers, a positive result was obtained. Sequencing of the RT-PCR products revealed that the DNA fragments were identical to the lipocalin 1 (LCN1) encoding cDNA. LCN1 is an unusual lipocalin member that binds a variety of lipophilic compounds and exhibits cysteine proteinase inhibitor and antimicrobial activities. The local production and topographic distribution of LCN1 in the human tracheobronchial tree was then investigated by immunoperoxidase staining on thin-layer sections using a specific antiserum. LCN1 was detectable in the acini of serous mucosal glands and sometimes within the glandular lumen, suggesting excretion of the protein. The latter finding was tested and verified by Western blot analysis of bronchial secretions of healthy individuals. Furthermore, the results of SDS-PAGE and Western blot analysis of bronchial secretions from patients with cystic fibrosis (CF), which are usually characterized by an increase of airway lipids, suggested that LCN1 secretion was enhanced. Northern blot analysis of RNA from normal trachea and RNA isolated from tracheal biopsies of patients with CF indicated that induced secretion was due to an up-regulated expression of the LCN1 gene. Thus, our investigations present the first clear evidence that LCN1 is induced in infection or inflammation and support the idea that this lipocalin functions as a physiologic protection factor of epithelia in vivo.
Assuntos
Brônquios/metabolismo , Proteínas de Transporte/metabolismo , Fibrose Cística/metabolismo , Traqueia/metabolismo , Adolescente , Adulto , Sequência de Aminoácidos , Sequência de Bases , Proteínas de Transporte/genética , Criança , Pré-Escolar , Feminino , Humanos , Imuno-Histoquímica , Lipocalina 1 , Masculino , Dados de Sequência Molecular , Mucosa/metabolismo , RNA Mensageiro/metabolismo , Valores de Referência , Distribuição TecidualRESUMO
The combination of tacrolimus (TAC) and mycophenolate mofetil (MMF) is frequently used for immunosuppression after organ transplantation (Tx), but the pharmacokinetics and interactions between the two drugs are poorly elucidated. We describe here the increase of TAC trough levels during MMF-induced diarrhea in a 8-yr-old boy after kidney Tx. Early dose reduction of TAC, together with short-term monitoring of TAC trough levels in the presence of diarrhea, is recommended.
Assuntos
Imunossupressores/efeitos adversos , Ácido Micofenólico/efeitos adversos , Tacrolimo/sangue , Criança , Interações Medicamentosas , Monitoramento de Medicamentos , Humanos , Imunossupressores/administração & dosagem , Imunossupressores/sangue , Masculino , Ácido Micofenólico/análogos & derivados , Tacrolimo/administração & dosagemRESUMO
Three patients, aged five to 16 years, developed chorea as the only or main clinical manifestation of primary antiphospholipid syndrome. In two cases, complaints were self-limited five to eight months after onset. In one patient, the clinical course was complicated by valvulitis. Under corticosteroid treatment, chorea disappeared and cardiac involvement stabilised. Primary antiphospholipid syndrome is a probably under-recognised differential diagnosis of choreatic syndromes in childhood. Assessment of anticardiolipin antibodies and/or lupus anticoagulant should be an obligatory part of the diagnostic work-up of such patients. Early diagnosis of primary antiphospholipid syndrome may improve clinical management and prognosis.
Assuntos
Síndrome Antifosfolipídica/diagnóstico , Coreia/etiologia , Adolescente , Corticosteroides/uso terapêutico , Anticorpos Anticardiolipina/sangue , Anticorpos Antinucleares/sangue , Síndrome Antifosfolipídica/complicações , Síndrome Antifosfolipídica/terapia , Aspirina/uso terapêutico , Pré-Escolar , Feminino , Valvas Cardíacas/diagnóstico por imagem , Valvas Cardíacas/fisiopatologia , Humanos , Inibidor de Coagulação do Lúpus/sangue , Masculino , Remissão Espontânea , Trombocitopenia/etiologia , Resultado do Tratamento , UltrassonografiaRESUMO
The authors report a preterm boy, born at 35 weeks gestation with hydrocephalus and an open sacral myelomeningocele. Cranial ultrasound showed ventricular dilatation with posture-dependent intraventricular bright echoes, representing air. Ultrasound of the cervical spine and the craniocervical junction revealed marked hydromyelia of the whole spinal cord, as well as a Chiari II malformation. Air penetrating the enlarged central canal through the neural tube defect and subsequently ascending to the cranial cavity was demonstrated by fluoroscopy. After a review of the literature, the authors conclude that the association of spontaneous pneumocephalus with myelomeningocele could indicate severe hydromyelia. These malformations are readily demonstrated by ultrasound in newborn infants.
Assuntos
Recém-Nascido Prematuro , Meningomielocele/complicações , Pneumocefalia/etiologia , Siringomielia/complicações , Humanos , Recém-Nascido , Masculino , Meningomielocele/diagnóstico por imagem , Pneumocefalia/diagnóstico por imagem , Radiografia , Siringomielia/diagnóstico por imagemRESUMO
The purpose of our study was to evaluate the effect of oral vaccination with Bordetella pertussis surface antigens on the immune response at the site of antigen application. We orally immunized female BALB/c mice on five consecutive days and repeated this procedure after a free interval of 10 days. Lymphocytes of the lung (LL), Peyer's patches (PPL) and lamina propria of the gut (LPL) were isolated and the immunoglobulin secretion rate was measured with time-resolved immunofluorescence. Oral immunization was found to enhance the IgA secretion rate by 69.9% in LL compared to unimmunized animals. The IgG synthesis in LL was increased by 28.1% and the IgM synthesis by 14.1%. In addition, an improvement of 47.8% was observed for the IgG secretion in LPL and PPL. Thus, our results demonstrate a strong local immune response after oral immunization with Bordetella pertussis.
Assuntos
Antígenos de Bactérias/administração & dosagem , Bordetella pertussis/imunologia , Pulmão/imunologia , Administração Oral , Animais , Formação de Anticorpos , Antígenos de Superfície/administração & dosagem , Feminino , Imunoglobulina A/imunologia , Imunoglobulina G/imunologia , Imunoglobulina M/imunologia , Linfócitos/imunologia , Camundongos , Camundongos Endogâmicos BALB C , Nódulos Linfáticos Agregados/imunologiaRESUMO
We describe a full-term immunocompetent neonate who developed jaundice at 3 weeks of age. Physical examination disclosed no abnormalities. Laboratory investigations showed direct reacting hyperbilirubinaemia and elevated liver enzymes. Liver biopsy revealed a non-caseating granulomatous hepatitis. The patient made an uneventful recovery within 4 weeks without therapy. Bacille Calmette-Guérin hypersensitivity reaction is suggested as the reason for this neonatal hepatitis.
Assuntos
Vacina BCG/efeitos adversos , Hepatite/etiologia , Vacinação/efeitos adversos , Biópsia , Seguimentos , Hepatite/patologia , Humanos , Lactente , Recém-Nascido , Icterícia Neonatal/etiologia , Fígado/patologia , MasculinoRESUMO
Rotavirus (RV) is the most common cause of diarrheal illness in children. We report three solid-organ-transplanted patients in whom RV infection caused increased trough levels of the immunosuppressive macrolide tacrolimus (TAC) by mechanisms that are still under investigation. The virus was detected for longer in the feces of these patients than in infants not receiving immunosuppressive therapy. In association with short-term monitoring of blood trough levels of TAC, the dosage should be reduced early if symptoms of an acute gastroenteritis are present.
Assuntos
Diarreia/sangue , Diarreia/virologia , Imunossupressores/sangue , Complicações Pós-Operatórias/sangue , Infecções por Rotavirus/sangue , Tacrolimo/sangue , Transplante , Adulto , Criança , Monitoramento de Medicamentos , Fezes/virologia , Feminino , Gastroenterite/sangue , Gastroenterite/virologia , Humanos , Imunossupressores/administração & dosagem , Lactente , Transplante de Rim , Transplante de Fígado , Transplante de Pulmão , Masculino , Tacrolimo/administração & dosagemRESUMO
Fibromuscular dysplasia (FMD) is a non-inflammatory segmental arteriopathy of unknown origin. Most often the renal arteries are affected, however, also mesenteric, lumbar, vertebral, or carotid arteries may be involved. FMD has frequently been reported as a cause of stroke in adults, but very rarely in children. We report the case of an 11-year-old boy who presented with an ischaemic infarction in the anterior part of the territory of the left middle cerebral artery. Angiography demonstrated a 'string of beads' lesion suggestive of FMD causing occlusion at the origin of the middle artery. Laboratory analyses revealed the protease inhibitor (Pi) phenotype SZ (PiSZ) of alpha-1-antitrypsin deficiency as well as decreased antioxidants and signs of enhanced lipid peroxidation. Such an imbalance may be associated with diminished resistance to oxidation, possibly causing direct cellular and tissue injury. Whether alpha-1-antitrypsin deficiency and an impaired status of antioxidants, as seen in our patient, might play a role in the pathogenesis of FMD is presently unclear.