Detalhe da pesquisa
1.
Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor.
Nature
; 518(7538): 240-4, 2015 Feb 12.
Artigo
Inglês
| MEDLINE | ID: mdl-25409150
2.
PI3K Inhibitors in Breast Cancer Therapy.
Curr Oncol Rep
; 21(12): 110, 2019 12 11.
Artigo
Inglês
| MEDLINE | ID: mdl-31828441
3.
How we treat advanced biliary tract cancers in the second-line setting.
Clin Adv Hematol Oncol
; 21(1): 35-42, 2023 01.
Artigo
Inglês
| MEDLINE | ID: mdl-36638354
4.
Extended adjuvant endocrine therapy in hormone-receptor-positive early breast cancer.
Curr Opin Oncol
; 28(6): 455-460, 2016 11.
Artigo
Inglês
| MEDLINE | ID: mdl-27606696
5.
Are FGFR Fusions and Mutations the Next Tumor-Agnostic Targets in Oncology?
JCO Precis Oncol
; 8: e2400113, 2024 May.
Artigo
Inglês
| MEDLINE | ID: mdl-38709991
6.
Landscape of Clinical Resistance Mechanisms to FGFR Inhibitors in FGFR2-Altered Cholangiocarcinoma.
Clin Cancer Res
; 30(1): 198-208, 2024 01 05.
Artigo
Inglês
| MEDLINE | ID: mdl-37843855
7.
FGFR inhibition blocks NF-ĸB-dependent glucose metabolism and confers metabolic vulnerabilities in cholangiocarcinoma.
Nat Commun
; 15(1): 3805, 2024 May 07.
Artigo
Inglês
| MEDLINE | ID: mdl-38714664
8.
The Irreversible FGFR Inhibitor KIN-3248 Overcomes FGFR2 Kinase Domain Mutations.
Clin Cancer Res
; 30(10): 2181-2192, 2024 May 15.
Artigo
Inglês
| MEDLINE | ID: mdl-38437671
9.
Allosteric PI3Kα Inhibition Overcomes On-target Resistance to Orthosteric Inhibitors Mediated by Secondary PIK3CA Mutations.
Cancer Discov
; 14(2): 227-239, 2024 Feb 08.
Artigo
Inglês
| MEDLINE | ID: mdl-37916958
10.
KRAS Wild-Type Pancreatic Cancer: Decoding Genomics, Unlocking Therapeutic Potential.
Clin Cancer Res
; 29(22): 4527-4529, 2023 11 14.
Artigo
Inglês
| MEDLINE | ID: mdl-37695631
11.
Comparative Effectiveness of Immune Checkpoint Inhibitors vs Chemotherapy in Patients With Metastatic Colorectal Cancer With Measures of Microsatellite Instability, Mismatch Repair, or Tumor Mutational Burden.
JAMA Netw Open
; 6(1): e2252244, 2023 01 03.
Artigo
Inglês
| MEDLINE | ID: mdl-36689222
12.
Masculine epigenetic sex marks of the CYP19A1/aromatase promoter in genetically male chicken embryonic gonads are resistant to estrogen-induced phenotypic sex conversion.
Biol Reprod
; 87(1): 23, 1-12, 2012 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-22539680
13.
Emerging Role of Targeted Therapy in Metastatic Pancreatic Adenocarcinoma.
Cancers (Basel)
; 14(24)2022 Dec 16.
Artigo
Inglês
| MEDLINE | ID: mdl-36551707
14.
Effective Treatment of Established Bone Metastases Can Be Achieved by Combinatorial Osteoclast Blockade and Depletion of Granulocytic Subsets.
Cancer Immunol Res
; 9(12): 1400-1412, 2021 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34551967
15.
Cell-free DNA alterations in the AR enhancer and locus predict resistance to AR-directed therapy in patients with metastatic prostate cancer.
JCO Precis Oncol
; 4: 680-713, 2020.
Artigo
Inglês
| MEDLINE | ID: mdl-32903952
16.
PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition.
Cancer Cell
; 30(2): 229-242, 2016 08 08.
Artigo
Inglês
| MEDLINE | ID: mdl-27451907
17.
PI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor-positive breast cancer.
Sci Transl Med
; 7(283): 283ra51, 2015 Apr 15.
Artigo
Inglês
| MEDLINE | ID: mdl-25877889
18.
MACC1 expression levels as a novel prognostic marker for colorectal cancer.
Oncol Lett
; 8(5): 2305-2309, 2014 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-25295116
19.
Antagonism of EGFR and HER3 enhances the response to inhibitors of the PI3K-Akt pathway in triple-negative breast cancer.
Sci Signal
; 7(318): ra29, 2014 Mar 25.
Artigo
Inglês
| MEDLINE | ID: mdl-24667376
20.
Single-cell RNA sequencing identifies extracellular matrix gene expression by pancreatic circulating tumor cells.
Cell Rep
; 8(6): 1905-1918, 2014 Sep 25.
Artigo
Inglês
| MEDLINE | ID: mdl-25242334