Detalhe da pesquisa
1.
Polymorphic debrisoquine 4-hydroxylase activity in the rat is due to differences in CYP2D2 expression.
Pharmacogenetics
; 9(3): 357-66, 1999 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-10471068
2.
In-vitro analysis of the contribution of CYP2D6.35 to ultra-rapid metabolism.
Pharmacogenetics
; 11(8): 739-41, 2001 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-11692084
3.
Variable contribution of cytochromes P450 2D6, 2C9 and 3A4 to the 4-hydroxylation of tamoxifen by human liver microsomes.
Biochem Pharmacol
; 53(2): 171-8, 1997 Jan 24.
Artigo
Inglês
| MEDLINE | ID: mdl-9037249
4.
Potent inhibition of yeast-expressed CYP2D6 by dihydroquinidine, quinidine, and its metabolites.
Biochem Pharmacol
; 50(6): 833-7, 1995 Sep 07.
Artigo
Inglês
| MEDLINE | ID: mdl-7575645
5.
Catalytic activities of human debrisoquine 4-hydroxylase cytochrome P450 (CYP2D6) expressed in yeast.
Biochem Pharmacol
; 44(4): 617-20, 1992 Aug 18.
Artigo
Inglês
| MEDLINE | ID: mdl-1510710
6.
The demethylenation of methylenedioxymethamphetamine ("ecstasy") by debrisoquine hydroxylase (CYP2D6).
Biochem Pharmacol
; 47(7): 1151-6, 1994 Mar 29.
Artigo
Inglês
| MEDLINE | ID: mdl-7909223
7.
Ab initio molecular modeling in the study of drug metabolism.
Eur J Drug Metab Pharmacokinet
; 22(4): 283-9, 1997.
Artigo
Inglês
| MEDLINE | ID: mdl-9512922
8.
A rare G2061 insertion affecting the open reading frame of CYP2D6 and responsible for the poor metabolizer phenotype.
Pharmacogenetics
; 9(3): 393-6, 1999 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-10471072
9.
The metabolism of tamoxifen by human liver microsomes is not mediated by cytochrome P450IID6.
Biochem Pharmacol
; 42 Suppl: S209-12, 1991 Dec 11.
Artigo
Inglês
| MEDLINE | ID: mdl-1768279
10.
Identification of a sterol mutant of Neurospora crassa deficient in delta 14,15-reductase activity.
J Gen Microbiol
; 137(11): 2627-30, 1991 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-1838392
11.
Theophylline antagonizes flurazepam-induced depression of cerebral cortical neurons.
Can J Physiol Pharmacol
; 57(8): 917-20, 1979 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-497904
12.
Cytochromes P450 mediating the N-demethylation of amitriptyline.
Br J Clin Pharmacol
; 43(2): 137-44, 1997 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-9131945
13.
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is N-demethylated by cytochromes P450 2D6, 1A2 and 3A4--implications for susceptibility to Parkinson's disease.
J Pharmacol Exp Ther
; 277(2): 685-90, 1996 May.
Artigo
Inglês
| MEDLINE | ID: mdl-8627546
14.
Variable contribution of CYP2D6 to the N-dealkylation of S-(-)-propranolol by human liver microsomes.
Br J Clin Pharmacol
; 42(3): 390-3, 1996 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-8877032
15.
Interaction of microsomal cytochrome P-450 isolated from Aspergillus fumigatus with fluconazole and itraconazole.
J Med Vet Mycol
; 28(4): 327-34, 1990.
Artigo
Inglês
| MEDLINE | ID: mdl-2176687
16.
A novel method for studying ergosterol biosynthesis by a cell-free preparation of Aspergillus fumigatus and its inhibition by azole antifungal agents.
J Med Vet Mycol
; 28(4): 335-44, 1990.
Artigo
Inglês
| MEDLINE | ID: mdl-2176688
17.
Defective sterol C5-6 desaturation and azole resistance: a new hypothesis for the mode of action of azole antifungals.
Biochem Biophys Res Commun
; 164(3): 1170-5, 1989 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-2556119
18.
An ab initio approach to the understanding of cytochrome P450-ligand interactions.
Xenobiotica
; 28(1): 15-20, 1998 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-9493315
19.
First principles investigation of singly reduced cytochrome P450.
Xenobiotica
; 29(6): 561-71, 1999 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-10426555
20.
Expression of human cytochrome P4501A1 (CYP1A1) in Saccharomyces cerevisiae inhibits cell division.
Xenobiotica
; 26(10): 1013-23, 1996 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-8905916