Detalhe da pesquisa
1.
Identification of aryl sulfonamides as novel and potent inhibitors of NaV1.5.
Bioorg Med Chem Lett
; 45: 128133, 2021 08 01.
Artigo
Inglês
| MEDLINE | ID: mdl-34044121
2.
Molecular Pharmacology of Selective NaV1.6 and Dual NaV1.6/NaV1.2 Channel Inhibitors that Suppress Excitatory Neuronal Activity Ex Vivo.
ACS Chem Neurosci
; 15(6): 1169-1184, 2024 03 20.
Artigo
Inglês
| MEDLINE | ID: mdl-38359277
3.
NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats.
Elife
; 112022 03 02.
Artigo
Inglês
| MEDLINE | ID: mdl-35234610
4.
Discovery of Novel, Orally Bioavailable Pyrimidine Ether-Based Inhibitors of ELOVL1.
J Med Chem
; 64(24): 17777-17794, 2021 12 23.
Artigo
Inglês
| MEDLINE | ID: mdl-34871500
5.
Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate.
Bioorg Med Chem Lett
; 20(24): 7312-6, 2010 Dec 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21055935
6.
Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy.
J Med Chem
; 62(21): 9618-9641, 2019 11 14.
Artigo
Inglês
| MEDLINE | ID: mdl-31525968
7.
Progress in Understanding and Treating SCN2A-Mediated Disorders.
Trends Neurosci
; 41(7): 442-456, 2018 07.
Artigo
Inglês
| MEDLINE | ID: mdl-29691040
8.
Pyridazinoquinolinetriones as NMDA glycine-site antagonists with oral antinociceptive activity in a model of neuropathic pain.
J Med Chem
; 50(13): 3113-31, 2007 Jun 28.
Artigo
Inglês
| MEDLINE | ID: mdl-17542571
9.
Real-time in situ Raman analysis of microwave-assisted organic reactions.
Appl Spectrosc
; 58(1): 41-6, 2004 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-14727719
10.
Lessons learned from candidate drug attrition.
IDrugs
; 13(12): 869-73, 2010 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-21154145
11.
Synthesis of 7-chloro-2,3-dihydro-2-[1-(pyridinyl)alkyl]-pyridazino[4,5-b]quinoline-1,4,10(5H)-triones as NMDA glycine-site antagonists.
Bioorg Med Chem Lett
; 13(20): 3553-6, 2003 Oct 20.
Artigo
Inglês
| MEDLINE | ID: mdl-14505669