Protective effect of aerobic exercise on the vocal folds against cigarette smoke exposure.

PURPOSE: Laryngeal pathologies due to cigarette smoking vary among individuals, whereas some smokers remain disease free. These differences can be explained by multiple factors among individuals. In this context, an animal study was designed to determine if there is any protective effect of aerobic exercise against the detrimental effects of cigarette smoke on laryngeal tissues. METHODS: A total of 24 male Wistar albino rats were divided into three groups of eight animals each: control (no smoke exposure), smoking (smoke exposure), and exercise (smoke exposure and exercise) groups. Histopathological (light and electron microscopy) and immunohistochemical (GSTA1, CYP1A1, CYP2E1) evaluations of the vocal folds were performed at the end of experimental period. RESULTS: Exercise group revealed statistically significant decrease in edema (p = 0.03) and inflammatory cell infiltration (p = 0.02) compared to smoking group. In electron microscopic evaluation; cytoplasmic vacuoles were also present in exercise group, but were smaller than smoking group. Edema and swollen mitochondria were also less prominent in exercise group. Condensed chromatin material in the periphery of nucleus was observed only in few cells in exercise group, and observed in more cells in smoking group. GSTA1 expression was higher (p = 0.047) and CYP1A1 expression was lower (p = 0.01) in exercise group than smoking group. CONCLUSIONS: Our results indicate that aerobic exercise has a protective role on the larynx against the damaging effect of cigarette smoke. Smokers who exercise regularly may be at a lower risk of cigarette smoke-related laryngeal diseases, as compared with those who do not exercise.

The effect of nasal septum deviation on voice aging.

PURPOSE: The aging process of the voice differs among individuals, and the factors that affect age-related changes in voice are not well-defined. In this study, we investigated the difference between older people with nasal septum deviation (NSD) and older people without NSD in terms of degree of aging voice using objective and subjective voice assessment tools. METHODS: The study included 94 patients (47 women, 47 men) aged >65 years. Nasal septum deviation was determined in 45 patients (NSD group), and 49 patients had no nasal pathology (control group). Maximum phonation time (MPT), GRBAS scale, and acoustic voice analysis parameters were compared between the NSD and control groups; sub-group analysis disaggregated by sex was also performed. RESULTS: No significant difference was observed between the NSD and control groups with respect to MPT, GRBAS scale, and acoustic voice analysis parameters in the total study population and among male subjects. The only parameter that showed a significant difference between sub-groups of female subjects was soft phonation index (SPI) (p=.03). CONCLUSIONS: To the best of our knowledge, this is the first study to analyze the effect of NSD on the voice aging. With the findings of the present study, NSD does not seem to have an effect on voice aging, and also it can be suggested that septoplasty will not have an effect on preventing presbyphonia. Further studies on larger groups of patients are required to provide more definitive evidence on this subject.

Acoustic and perceptual voice parameters in subclinical and overt primary hypothyroidism.

OBJECTIVE: Hypothyroidism is a common endocrine disorder affecting various systems of the body. Only a few studies have focused on the effect of primary hypothyroidism on voice with objective parameters, and none of them compared the effect of subclinical and overt hypothyroidism on voice. The aim of the present study is to evaluate and compare the acoustic and perceptual parameters of voice in patients newly diagnosed with subclinical and overt hypothyroidism. METHODS: The study included 26 subclinical hypothyroidism, 26 overt hypothyroidism patients and 30 euthyroid control participants. Perceptual evaluation of voice with GRBAS (grade, roughness, breathiness, asthenia, strain) scale, voice handicap index (VHI)-10, and acoustic voice analysis by using Multi-Dimensional Voice Program were performed for all the participants. RESULTS: The voice parameters which showed a statistically significant difference between the groups were frequency parameters (Fo; p= 0.003, Fhi; p=0.010, Flo; p= 0.002) and VHI-10 (p= 0.047). A statistically significant decrease in frequency parameters and a statistically significant increase in VHI-10 were found in overt hypothyroidism group comparing with control group (Fo; p= 0.002, Fhi; p=0.009, Flo; p= 0.001 and VHI-10; p= 0.046). Voice parameters in subclinical hypothyroidism group did not show a statistically significant difference comparing with both control and overt hypothyroidism groups. CONCLUSION: In the present study, overt hypothyroidism is found to affect frequency parameters and patients' own subjective assessment of voice. Primary hypothyroidism does not seem to have significant effect on voice parameters until thyroxine levels are affected.