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1.
J Minim Access Surg ; 18(3): 431-437, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35708387

RESUMO

Aim: In this study, we aimed to investigate the effect of magnetic resonance imaging (MRI) in detecting diaphragmatic injury by comparing preoperative computed tomography (CT) and MRI imaging results with diagnostic laparoscopy/thoracoscopy results in patients with left thoracoabdominal penetrating injury. We investigated whether MRI reduces the rate of unnecessary surgery by examining its sensitivity and specificity. Materials and Methods: Patients with left thoracoabdominal penetrating injuries who applied to the Emergency Surgery Unit of Istanbul University Istanbul Faculty of Medicine between November 2017 and December 2020 were evaluated. Patients who underwent emergency surgery, who could not undergo MRI or CT for any reason or who could not be operated on were excluded from the study. Preoperative MRI and CT images of patients who underwent diagnostic laparoscopy/thoracoscopy due to left thoracoabdominal injury in our clinic were evaluated retrospectively by a radiologist who did not know the surgical results. MRI results of the cases were compared with surgical findings and CT images. Results: A total of 43 (41 males, mean age: 31, range: 15-57) patients were included in the study. The most common physical examination finding was lateral injury. The diaphragmatic injury was detected in 13 (30%) cases during surgical interventions. Laparoscopic repair was performed in 11 (84%) cases and thoracoscopic repair was performed in 2 (15%) cases with diaphragmatic injuries. MRI images of 14 (32%) cases were found to be compatible with diaphragmatic injury, in 1 of them no injury was observed during surgical intervention. According to these data, the sensitivity of MRI was calculated as 100%, specificity 94%, positive predictive value 86%, and negative predictive value 100%. The mean hospital stay was 6 days (1-30) in all cases. Conclusion: In our study, MRI was found to have high specificity and sensitivity in detecting diaphragmatic injuries. The number of negative laparoscopy/thoracoscopy can be reduced by performing surgical intervention only in cases with positive or suspected diaphragmatic injury on MRI. Results should be supported by conducting new studies with larger case series with normal MRI findings and long follow-ups.

2.
Ulus Travma Acil Cerrahi Derg ; 20(1): 23-7, 2014 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-24639311

RESUMO

BACKGROUND: In recent decades, the use of colorectal stents for palliation or as a bridge to surgery in acute malignant colorectal obstruction has increased. We aimed to evaluate the technical and clinical efficacy, safety and clinical outcomes of endoscopic stenting for the relief of acute colorectal obstruction secondary to cancer. METHODS: From March 2006 to December 2012, among 100 patients with acute malignant colorectal obstruction, stenting procedures were performed on 42 patients for relief of obstruction. Uncovered self-expanding metal stents (SEMS) were placed endoscopically under fluoroscopic guidance in all patients. Using the patient database, a review was conducted to determine the effectiveness of the procedure and the short- and long-term complications. RESULTS: Stent placement was technically successful in 39/42 (92.8%) and clinically successful in 38/42 (90.4%) patients. Sixteen patients later underwent an elective surgical resection, and in 26 patients with metastatic disease or comorbidity, stent placement was palliative. Complications occurred in 10 (23.8%) patients, and the most common was tenesmus (n=3). Migration, bleeding, and recto-sigmoid perforation occurred in two patients each. Stent obstruction due to fecal impaction was seen in one case. CONCLUSION: Stent placement for colorectal obstruction is an effective and relatively safe procedure, with minor complications. It not only allows subsequent elective resection, but is also definitive for palliative treatment in patients with obstructive colorectal cancer.


Assuntos
Neoplasias Colorretais/cirurgia , Obstrução Intestinal/cirurgia , Stents , Adulto , Idoso , Idoso de 80 Anos ou mais , Neoplasias Colorretais/complicações , Humanos , Obstrução Intestinal/etiologia , Pessoa de Meia-Idade , Estudos Retrospectivos
3.
Arch Gynecol Obstet ; 288(6): 1275-8, 2013 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-23715923

RESUMO

BACKGROUND: The current guidelines recommend endoscopic retrograde cholangiopancreatography (ERCP) procedures in pregnant women with minimal radiation exposure. Regarding the safety of ERCP during pregnancy, data are limited in the literature. In this study, we report our experience with five ERCP procedures performed in five pregnant women without radiation at a single tertiary health center. METHODS: Between May 2007 and February 2012, five pregnant patients underwent ERCP without radiation, analyzed retrospectively. Clinical disease was confirmed with either pre-procedure ultrasonography and magnetic resonance cholangiopancreatography in all patients. In all cases, selective deep cannulation was performed and confirmed by the aspiration and/or direct visualization of the bile. The data regarding laboratory, ultrasonography, magnetic resonance imaging, endoscopic findings, and clinical course of the patients were analyzed. Fetal complications were noted at delivery and 30 days postdelivery follow-up. RESULTS: The mean patient age was 26 years (22-33) and the mean duration of pregnancy was 20 weeks (12-32). In all cases, no secondary ERCP procedures were needed. Also, no maternal and fetal adverse events and complications were determined after the procedures or on follow-up. All stages of the procedure including cannulation, sphincterotomy, and stone extraction were performed without the use of fluoroscopy. CONCLUSION: As far we know, there is no report in the literature regarding the failure of endoscopic retraction of stones without fluoroscopy during pregnancy. Our series notes that ERCP is safe and prevents recurrent biliary pancreatitis during pregnancy. Unfortunately, due to the small limited number of patient data, our study notes the requirement of further large randomized and controlled series.


Assuntos
Colangiopancreatografia Retrógrada Endoscópica/métodos , Colangite/diagnóstico , Coledocolitíase/cirurgia , Pancreatite/complicações , Complicações na Gravidez/cirurgia , Adulto , Colangite/terapia , Coledocolitíase/complicações , Feminino , Idade Gestacional , Humanos , Imageamento por Ressonância Magnética , Pancreatite/cirurgia , Gravidez , Complicações na Gravidez/diagnóstico , Resultado da Gravidez , Gravidez de Alto Risco , Estudos Retrospectivos , Resultado do Tratamento
4.
Ulus Travma Acil Cerrahi Derg ; 19(3): 246-50, 2013 May.
Artigo em Inglês | MEDLINE | ID: mdl-23720113

RESUMO

BACKGROUND: The aim of this study is to determine the type and cause of traumatic orofacial injuries in children up to 18 years of age. METHODS: This retrospective study involved data collected from 12055 patients that came to Istanbul University, Medical Faculty, Department of Emergency in 2011. The patients' data were evaluated with regard to age, gender, etiologic factor of the trauma, type and localization of the injury, and time interval between injury and treatment. RESULTS: A total of 1296 children in 12055 patients with orofacial trauma were evaluated. Trauma incidence was higher in boys (65%). The major etiologic factor of injury was falls (56%) and primary localization was in the frontal region (41%). The most frequent types of injury were laceration (30.1%) and hematoma (18.6%). 4% of the injuries were found in the orodental region including lips, teeth, tongue and oral mucosa of the mouth. 38% of the patients came to the emergency department within 30-60 minutes after the injury and 68% were sent home with symptomatic treatment. CONCLUSION: Considering the high percentage of orofacial traumas, effective education is necessary regarding the appropriate diagnostic approach, emergency management and prevention of traumatic dental injuries.


Assuntos
Traumatismos Faciais/epidemiologia , Adolescente , Criança , Pré-Escolar , Serviço Hospitalar de Emergência/estatística & dados numéricos , Traumatismos Faciais/diagnóstico , Traumatismos Faciais/terapia , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Estudos Retrospectivos , Turquia/epidemiologia
5.
Ulus Travma Acil Cerrahi Derg ; 29(6): 663-668, 2023 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-37278080

RESUMO

BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic has affected all aspects of clinical care including diagnosis and treatment of colorectal cancers (CRCs) globally, including in Türkiye. During the initial peak of the pandemic, elective surgeries and outpatient clinics were restricted in addition to the government-imposed lockdown, resulting in a decrease in the number of colonoscopies being performed and patients admitted to inpatient wards for treatment of CRCs. In this study, we aimed to investigate whether the pandemic has affected presentation characteristics and outcomes of obstructive colorectal cancer in this period. METHODS: This is a single-center, retrospective cohort study based on all CRC adenocarcinoma patients that underwent surgical resection in a high-volume tertiary referral center in Istanbul, Türkiye. Patients were divided into two groups before and after 15 months of identification of 'patient-zero' in Türkiye (March 18, 2020). Patient demographics, initial presentation characteristics, clin-ical outcomes, and pathological cancer stages were compared. RESULTS: Overall, 215 patients underwent resection for CRC adenocarcinoma during 30 months (COVID era: 107, pre-COVID era: 108). Patient characteristics, tumor location, and clinical staging were comparable between two groups. During the COVID period, the number of obstructive CRCs (P<0.01) and emergency presentations (P<0.01) increased significantly compared to the respective pre-COVID period. However, there were no differences between 30-day morbidity, mortality, and pathological outcomes (P>0.05). CONCLUSION: Although the results of our study indicate a significant increase in emergency presentation and a decrease in elective admissions of CRCs during the pandemic, patients treated during the COVID period were not at a significant disadvantage in terms of post-operative outcomes. Further efforts should be made to decrease risks related to an emergency presentation of CRCs for future adverse events.


Assuntos
Adenocarcinoma , COVID-19 , Neoplasias Colorretais , Humanos , COVID-19/epidemiologia , Estudos Retrospectivos , Pandemias , Controle de Doenças Transmissíveis , Neoplasias Colorretais/epidemiologia , Neoplasias Colorretais/cirurgia , Adenocarcinoma/epidemiologia , Adenocarcinoma/cirurgia
6.
Ulus Travma Acil Cerrahi Derg ; 18(1): 61-4, 2012 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-22290052

RESUMO

BACKGROUND: We reviewed retrospectively TV-related injuries to determine the risk factors, type of injuries, and operative intervention(s) required in children injured by falling TVs. METHODS: This was a retrospective descriptive study conducted on 42 pediatric patients who were admitted to Istanbul University, Istanbul Medical Faculty, Emergency Surgery Department. Case notes included all demographic and injury details, TV and TV-related furniture type, mechanism of injury, Pediatric Trauma Score (PTS), Pediatric Glasgow Coma Scale (PGCS), length of hospital stay, need for intensive care unit assessments, and management plans. RESULTS: More than 65% of the children were aged 1 to 3 years. The injury rate was higher for boys (66.7%) than girls (33.3%). Of the 42 patients identified, 17 (40.5%) sustained only head injuries, with almost half of these having a definite traumatic brain injury; 6 (14.3%) had only thoracic injury, and 4 (9.5%) had only limb injury. The PGCS ranged from 3 to 15, with a mean of 7. The PTS ranged from -6 to 12, with a mean of 9. Five children (11.9%), all aged 2 years or younger, died in the hospital as a result of the TV-related injury, all sustaining head and thorax injuries, which are reflected in a significantly lower PTS and lower PGCS on admission compared with older children. TV falls on to children often occur because of unstable supports, with dressers and shelves being the most common. The most common mechanism of injury (71.4%) among all age groups was fall/tipping of furniture. Pulling the furniture onto oneself (19%) was the second most frequent mechanism of injury. CONCLUSION: Injuries related to TV falls can lead to significant morbidity and mortality in children. As they are preventable injuries, restricted activity and improved supervision of children around the TV can potentially lead to fewer incidences.


Assuntos
Acidentes Domésticos , Ferimentos não Penetrantes/epidemiologia , Adolescente , Criança , Pré-Escolar , Feminino , Escala de Coma de Glasgow , Traumatismos Cranianos Fechados/epidemiologia , Traumatismos Cranianos Fechados/patologia , Traumatismos Cranianos Fechados/prevenção & controle , Humanos , Escala de Gravidade do Ferimento , Tempo de Internação , Masculino , Estudos Retrospectivos , Televisão , Turquia/epidemiologia , Ferimentos não Penetrantes/patologia , Ferimentos não Penetrantes/prevenção & controle
7.
Ulus Travma Acil Cerrahi Derg ; 18(1): 18-22, 2012 Jan.
Artigo em Turco | MEDLINE | ID: mdl-22290045

RESUMO

BACKGROUND: This research was conducted to analyze the impact of visiting patients in the intensive care unit on the vital signs of the patients. METHODS: This descriptive study was conducted at the emergency surgical intensive care unit of a university hospital in Istanbul. The sample consisted of 43 patients aged 18 and above, who stayed at the unit for more than 24 hours. Data collection included the demographic features of the patients as well as the information and evaluation form including the vital signs of patients before, during and after visits. Data were measured before, during and after visits. RESULTS: 39.5% (n=17) of the patients were female and 60.5% (n=26) were male. Values before and after visits, respectively, were as follows: Mean fever 36.7±0.81 and 36.8±.94; pulse 97.3±26.4 and 98.4±26.1; mean respiration 23.76±4.55 and 24.30±4.53; systolic pressure 113.4±25.86 and 120.4±21.15; and diastolic pressure 64.81±8 and 67.30±3. CONCLUSION: This study, carried out as a pilot study, found that visiting patients in intensive care units affects the patients; however, this effect does not cause a serious physiological change in the vital signs of the patient.


Assuntos
Pressão Sanguínea , Emergências , Pacientes/psicologia , Visitas a Pacientes , Adolescente , Adulto , Serviço Hospitalar de Emergência , Feminino , Humanos , Unidades de Terapia Intensiva , Masculino , Projetos Piloto , Turquia , Adulto Jovem
8.
Ulus Travma Acil Cerrahi Derg ; 28(6): 776-780, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-35652882

RESUMO

BACKGROUND: The use of antitrombotic (antiaggregant and anticoagulant) drugs is increasing all over the world and in our coun-try. About 12.6% of patients who underwent gastrointestinal tumor surgery receive antitrombotic therapy for various reasons, and in this study, we aimed to demonstrate the safe feasibility of elective or emergency gastrointestinal tumor surgery with the correct perioperative antitrombotic therapy management. METHODS: The patients who were planned for gastrointestinal tumor surgery under antitrombotic treatment were analyzed in three groups as those whose pre-operative treatment management treatment was discontinued, those who underwent bridging treat-ment, and those whose treatment continued. Anti-embolic stockings or intermittent pneumatic compression devices were applied to all patients preoperatively and postoperatively as mechanical prophylaxis. Post-operative complications, especially post-operative bleeding and thrombosis, were evaluated using the Clavien-Dindo post-operative complication classification. RESULTS: When patients who were under antithrombotic therapy, whose therapy was discontinued, and who underwent surgery under bridging therapy, no significant difference was found between the three groups in terms of bleeding complications. CONCLUSION: In tertiary centers with high clinical experience, elective and emergency gastrointestinal system tumour surgery can be safely performed under antitrombotic therapy without increasing the thromboembolic risk.


Assuntos
Procedimentos Cirúrgicos do Sistema Digestório , Neoplasias Gastrointestinais , Anticoagulantes/efeitos adversos , Procedimentos Cirúrgicos Eletivos , Neoplasias Gastrointestinais/tratamento farmacológico , Neoplasias Gastrointestinais/cirurgia , Humanos , Complicações Pós-Operatórias/tratamento farmacológico , Complicações Pós-Operatórias/prevenção & controle
9.
Ulus Travma Acil Cerrahi Derg ; 28(5): 579-584, 2022 May.
Artigo em Inglês | MEDLINE | ID: mdl-35485462

RESUMO

BACKGROUND: Injury is the leading cause of death for pediatric population older than 1 year of age and 95% of those deaths are from the low- and middle-income countries. Most of those injured pediatric patients are treated in general hospitals. In designated trauma centers, the outcomes of severely injured patients are better. Scoring systems used frequently in intensive care units (ICUs) to make triage easier and to estimate prognosis. However, some of the scores may require additional expensive and sometimes time consuming tests. The purpose of the present study was to compare the usefulness of several scoring systems with initial ionized calcium levels and platelet counts to predict prognosis of pediatric trauma patients admitted to the emergency surgery department. METHODS: This retrospective study was performed at a tertiary university hospital. The patients' ages, genders, trauma etiologies, types of trauma, time of trauma, transport place (primary or secondary), duration of stay in the ICU and in the hospital, mortality rates, initial ionized calcium levels (Ca+2), initial platelet counts, and data of several trauma scores (GCS, RTS, ISS, TRISS, and PTS) were analyzed. RESULTS: One hundred and fourteen pediatric trauma patients were admitted to the ICU. The mean age was 77.8±54 months. Most of them were male, falls were the primary mechanism of injury, and head trauma was the most common pattern of injury. The mortality rate was 15.8%, and the admission values for Ca+2, platelet counts, GCS, RTS, TRISS, and PTS had been found higher for patients who survived, while ISS scores were higher for those who had died. CONCLUSION: It was found that pediatric patients admitted to the ICU were younger than 10 years, of whom most of them were male. Falls were the most common mechanism of injury, and head trauma was present in most of the pediatric patients admitted to the ICU. Initial Ca+2 levels and platelet counts can be used along with the trauma scoring systems in predicting mortality and overall survey regarding pediatric trauma patients.


Assuntos
Cálcio , Traumatismos Craniocerebrais , Criança , Pré-Escolar , Cuidados Críticos , Feminino , Humanos , Lactente , Masculino , Contagem de Plaquetas , Prognóstico , Estudos Retrospectivos
10.
Ulus Travma Acil Cerrahi Derg ; 28(4): 537-540, 2022 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-35485507

RESUMO

Actinomycosis is a rare, chronic granulomatous disease that is challenging to diagnose because the clinical symptoms and signs are nonspecific. Usage of intrauterine device (IUD) or being immunocompromised is facilitating factors. Clinical and radiological findings can mimic malignant neoplasm, inflammatory bowel disorder, or acute diverticulitis. We report a case of actinomyces infection of the colon secondary to IUD, which is a rare cause of acute abdominal pain and can mimic a malignant neoplasm. We also provide a review of the literature. Unnecessary surgery can be avoided with the correct diagnosis of granulomatous infectious diseases that can be treated with antibiotics.


Assuntos
Abdome Agudo , Actinomicose , Dispositivos Intrauterinos , Neoplasias , Dor Abdominal/etiologia , Actinomicose/diagnóstico , Actinomicose/tratamento farmacológico , Actinomicose/etiologia , Colo/patologia , Feminino , Humanos , Dispositivos Intrauterinos/efeitos adversos , Neoplasias/complicações
11.
Ulus Travma Acil Cerrahi Derg ; 27(1): 132-138, 2021 01.
Artigo em Inglês | MEDLINE | ID: mdl-33394481

RESUMO

BACKGROUND: Acute left colonic diverticulitis (ALCD) ranges from localized diverticulitis to perforation and fecal peritonitis, and treatment varies from conservative management to emergency surgery. The risk factors for recurrence following nonoperative management of ALCD is still controversial. We aimed to define the factors predicting severity level, progression and recurrence risk of ALCD to timely select patients requiring surgery. METHODS: This is a multicenter study where patients were included on accrual. Patients in our clinic between December 2017 and June 2019 with ALCD above 18 years of age were included (n=144) in this study, while 18 years and younger, pregnant or nursing mothers, those with Crohn's disease, ulcerative colitis, colorectal and/or anal cancer were excluded from this study. Laboratory parameters, Modified Hinchey Scores, clinical features, demographics, diet, smoking, alcohol consumption, body mass index, previous diverticulitis episodes, chronic diseases of patients with ALCD, as well as recurrences within 18 months after discharge were evaluated. RESULTS: The findings showed that smoking was more common in patients with previous episodes (p=0.04) and patients who underwent emergency surgery (p=0.04). Recurrence was higher in Modified Hinchey 1b and 2 (p=0.03) than 0 and 1a. Patients who were older than 50y had a higher propensity to undergo emergency surgery than the patients younger than 50y (p=0.049). Nausea, fever, respiratory rate, procalcitonin, total bilirubin and direct bilirubin levels were higher in patients with Modified Hinchey 4 (p=0.03, 0.049, 0.02, 0.001, 0.002, 0.001, respectively). Recurrence was higher in patients with a smoking history, previous ALCD episodes, lower body mass index and pandiverticulitis. CONCLUSION: Laboratory parameters, body mass index, age, clinical features, previous episodes of diverticulitis and smoking may predict the severity and progression of ALCD. Smoking and having low BMI seem to be precursors of ALCD recurrence, especially when the patient with MHS 1b or 2 had at least one previous episode of ALCD. Control colonoscopy results are predictive of recurrence.


Assuntos
Doença Diverticular do Colo , Índice de Massa Corporal , Doença Diverticular do Colo/epidemiologia , Doença Diverticular do Colo/patologia , Doença Diverticular do Colo/fisiopatologia , Humanos , Recidiva , Fatores de Risco , Fumar , Turquia
12.
Mediators Inflamm ; 2010: 482950, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-20396411

RESUMO

Proinflammatory cytokines, such as tumour necrosis factor alpha (TNFalpha), play fundamental roles in the pathogenesis of acute pancreatitis (AP). The aim of this study was to determine if polymorphisms in the TNFalpha gene are associated with AP. Two polymorphisms located in the promoter region (positions -308 and -238) in TNFalpha gene were determined using polymerase chain reaction- (PCR-) restriction fragment length polymorphism (RFLP) methods in 103 patients with AP and 92 healthy controls. Odds ratios (ORs) and 95% confidence intervals (CI) were estimated using logistic regression analysis adjusted for age, sex, BMI and smoking. The frequencies of TNFalpha polymorphisms were both similar in patients with mild or severe pancreatitis, so were in pancreatitis patients and in controls. We suggest that both SNPs of TNFalpha are not genetic risk factor for AP susceptibility (OR = 1.63; 95% CI: 1.13-4.01 for TNFalpha(-308) and OR = 0.86; 95% CI: 0.75-1.77 for TNFalpha(-238)).


Assuntos
Pancreatite/genética , Polimorfismo Genético , Fator de Necrose Tumoral alfa/genética , Doença Aguda , Adulto , Idoso , Feminino , Predisposição Genética para Doença , Humanos , Masculino , Pessoa de Meia-Idade , Pancreatite/imunologia
13.
Ulus Travma Acil Cerrahi Derg ; 26(3): 335-342, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32394416

RESUMO

COVID-19 is a new disease, based on currently available limited information, older adults and people of any age who have severe underlying medical conditions may be at higher risk for severe illness from COVID-19. People of all age groups are also at risk. Healthcare providers have always been the professionals most exposed to the risk of contracting to any kind of infection due to the nature of their profession. Elective interventions have been postponed to give care of patients with COVID-19. However, some interventions cannot be delayed, such as trauma surgery, acute abdomen, and emergency endoscopies. To maintain the sustainability of the healthcare system, the protection of healthcare providers should be the top priority. On the other hand, patients, who need emergency healthcare, should also be provided with appropriate treatment. Healthcare professionals should choose a treatment method appropriately in the circumstances to protect themselves and their patients as much as possible. This paper aims to summarize how a surgeon may act appropriately when an intervention is inevitable during the COVID-19 pandemic.


Assuntos
Betacoronavirus , Infecções por Coronavirus/complicações , Serviço Hospitalar de Emergência , Pneumonia Viral/complicações , Ferimentos e Lesões/cirurgia , Abdome Agudo/cirurgia , Idoso , COVID-19 , Infecções por Coronavirus/epidemiologia , Serviço Hospitalar de Emergência/normas , Feminino , Humanos , Masculino , Pandemias , Pneumonia Viral/epidemiologia , Fatores de Risco , SARS-CoV-2
14.
Transplant Proc ; 51(6): 2132-2135, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31399189

RESUMO

OBJECTIVE: We aimed to compare the clinical and histopathological results of skin graft transplants between rats that had been injected with lymphocytes into the anterior chamber of the eye with those that had not. METHODS: A total of 16 Wistar albino, male rats were included in the study. Subjects were divided into 2 groups, namely a test group and a control group. Lymphocyte suspensions derived from the subjects of the control group were injected into the anterior chamber of the eye of each opposing subject of the test group. Also, an identical volume of physiological saline was injected into the anterior chamber of each subject in the control group to prevent bias. One week after this procedure, circular skin grafts of 1 cm in diameter were transplanted within the opposing groups. After a period of 1 week, transplanted graft tissues were excised to compare tissue healing. RESULTS: The occurence of granulation and reepithelialization was more evident in the test group (96% and 33%, respectively, vs 80% and 17% for the control group, respectively). On the other hand, it was determined that acute inflammation was more intense in the control group (77% vs 50% for the test group). CONCLUSION: We had created immune tolerance in rats through anterior chamber lymphocyte injection, which slowed down the rejection process. If this can be successfully implemented in practice, survival for transplant patients without long-term rejection will move closer to becoming a reality.


Assuntos
Câmara Anterior/imunologia , Sobrevivência de Enxerto/imunologia , Linfócitos/imunologia , Transplante de Pele/métodos , Tolerância ao Transplante/imunologia , Animais , Masculino , Ratos , Ratos Wistar
15.
Ulus Travma Acil Cerrahi Derg ; 25(4): 424-426, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31297779

RESUMO

Transvaginal small bowel evisceration is a rare, life-threatening condition, requiring urgent surgical intervention. In our case, ischemia developed in the intestinal segment with evisceration, with a laceration in the small intestine of the mesentery, and finally, a small bowel resection was required. An 89-year-old woman was brought to the hospital with a sudden onset of abdominal pain, which lasted for 4 hours. Upon the examination, it was found that approximately 50 cm of the small intestine was eviscerated from the vagina, with its mesentery. The intestines were edematous, and also there were signs of ischemia on the mesentery. The patient was urgently transferred to surgery. Functional end-to-end anastomosis was performed, following a 70 cm small bowel resection. The vaginal defect was repaired transvaginally. Transvaginal small bowel evisceration is rarely described in the literature. It is most commonly seen in postmenopausal, elderly women who underwent vaginal surgery before and who have enterocele. The treatment is an emergent surgical approach. Surgical treatment should be based on individual patient. Various surgical techniques have been described for the repair of transvaginal small bowel evisceration, such as vaginal, abdominal, laparoscopic, and combined approaches. Transvaginal small bowel evisceration should be considered in the differential diagnosis of patients with a sudden onset abdominal pain. Patients with an increased risk for transvaginal small bowel evisceration are postmenopausal women and patients who underwent vaginal surgery before. After the accurate diagnosis, patients should be operated as soon as possible, and necessary surgery should be done.


Assuntos
Intestino Delgado/patologia , Intestino Delgado/cirurgia , Vagina/patologia , Dor Abdominal , Idoso de 80 Anos ou mais , Anastomose Cirúrgica , Diagnóstico Diferencial , Edema , Emergências , Feminino , Humanos , Histerectomia , Isquemia , Laparoscopia/métodos , Mesentério/irrigação sanguínea , Mesentério/patologia , Fatores de Risco , Vagina/cirurgia
16.
Langenbecks Arch Surg ; 393(3): 367-72, 2008 May.
Artigo em Inglês | MEDLINE | ID: mdl-17674029

RESUMO

OBJECTIVE: Although there are various experimental pancreatic models in animals, only a few studies have evaluated how intraductal pressure and contrast agent affect the development of pancreatitis after endoscopic retrograde cholangiopancreatograpy (ERCP). MATERIALS AND METHODS: The rats were randomly divided into seven groups (n = 8/group). The rats in all groups underwent laparotomy and their biliopancreatic ducts were cannulated transduodenally using a 24G catheter. In the control group, group 1, the biliopancreatic ducts of the rats were not infused with any fluid. The biliopancreatic ducts of the rats in groups 2, 3, and 4 were infused with 0.5 ml isotonic NaCl solution at 10, 2, and 50 mmHg, respectively. Groups 5, 6, and 7 were given 0.5 ml of 50% diluted contrast agent at 10, 25, and 50 mmHg, respectively. The serum amylase, aspartate aminotransferase (AST), lactic dehydrogenase (LDH), and C-reactive protein (CRP) were measured 24 h after the procedure. Pancreatic tissue was also evaluated histopathologically. RESULTS: Pancreatitis due to the contrast agent was noted when comparing the low pressure isotonic NaCl group and the low pressure contrast group (p < 0.05). Based on serum amylase and CRP values, there was a positive correlation between the severity and frequency of acute pancreatitis and pressure (p < 0.01). AST and LDH levels increased in all of the groups that underwent the procedure; however, no correlation was detected with increasing pressure or with the use of contrast agent (p > 0.05). Both pancreatic edema and the inflammatory cell infiltration score were elevated in isotonic NaCl and contrast group (p < 0.05); however, necrosis was not significantly changed (p > 0.05). CONCLUSION: The results of this study suggest that the main mechanism for preventing pancreatitis after ERCP is to minimize trauma to the pancreatic canal, to cannulate the pancreas only when it is necessary, and to give contrast agent under low pressure when it is needed.


Assuntos
Colangiopancreatografia Retrógrada Endoscópica/efeitos adversos , Meios de Contraste/toxicidade , Iohexol/análogos & derivados , Ductos Pancreáticos/efeitos dos fármacos , Pancreatite Necrosante Aguda/induzido quimicamente , Amilases/sangue , Animais , Aspartato Aminotransferases/sangue , Proteína C-Reativa/metabolismo , Feminino , Pressão Hidrostática , Iohexol/toxicidade , L-Lactato Desidrogenase/sangue , Pâncreas/efeitos dos fármacos , Pâncreas/patologia , Pancreatite Necrosante Aguda/enzimologia , Pancreatite Necrosante Aguda/patologia , Ratos , Ratos Sprague-Dawley , Cloreto de Sódio/farmacologia
17.
J Trauma ; 64(4): 943-8, 2008 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-18404060

RESUMO

BACKGROUND: A number of large series' have attempted to examine the management of blunt solid organ injuries; however, only a few studies regarding multiple injuries exist. The aim of this study is to analyze whether multiple solid organ injury affects nonoperative management (NOM) and to look for predictive factors of NOM. METHODS: All patients admitted with a diagnosis of blunt solid organ injury between January 1, 1999 and January 1, 2005 were included in this prospective observational study. Of the 468 patients who had solid organ injury, 46 patients met the inclusion criteria of multiple solid organ injuries. Presentation, mechanism of injury, injury grade, Abbreviated Injury Scale score, management, and outcomes were analyzed. Independent predictive factors of NOM failure were identified. Patients managed nonoperatively were compared with patients who had had emergent laparotomy and patients for whom NOM failed. RESULTS: Fifteen patients (33%) underwent emergency laparotomy because of hypovolemic shock that was unresponsive to aggressive resuscitation, and 31 (66%) were selected for NOM. Among the 31 patients, NOM was successful in 23 (75%). No specific organ injury combination was found to affect NOM failure. Admission lactate level [odds ratio(OR), 1.44; 95% confidence interval (CI), 1.05-1.98; p = 0.025], a drop in the hematocrit greater than 20% in the first hour after admission (OR, 1.13; 95% confidence interval CI, 1.04-1.24; p = 0.007), and solid viscus score (OR, 1.67; 95% CI, 1.03-2.80; p = 0.04) were significant independent risk factors in those patients for whom NOM failed. In logistic regression analysis, hypotension at admission (OR, 0.96; 95% CI, 0.92-0.99; p = 0.014) and transfusion in the first 6 hours after admission (OR, 1.03; 95% CI, 1.00-1.05; p = 0.015) were found to significantly affect the success rate of nonoperative management. CONCLUSION: Lactate levels at admission, solid viscus score, necessity of transfusion, crystalloid resuscitation, and a drop in the hematocrit in the first hour after admission are useful parameters for judging the failure of NOM. Although there is a higher failure rate of NOM in multiple solid organ injury, NOM can still be considered in these cases with extra caution.


Assuntos
Traumatismos Abdominais/terapia , Traumatismo Múltiplo/terapia , Ferimentos não Penetrantes/terapia , Traumatismos Abdominais/mortalidade , Traumatismos Abdominais/cirurgia , Adolescente , Adulto , Idoso , Transfusão de Sangue , Estudos de Coortes , Intervalos de Confiança , Quimioterapia Combinada , Feminino , Seguimentos , Humanos , Escala de Gravidade do Ferimento , Rim/lesões , Fígado/lesões , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Traumatismo Múltiplo/mortalidade , Traumatismo Múltiplo/cirurgia , Razão de Chances , Probabilidade , Estudos Prospectivos , Medição de Risco , Baço/lesões , Análise de Sobrevida , Resultado do Tratamento , Turquia , Ferimentos não Penetrantes/mortalidade , Ferimentos não Penetrantes/cirurgia
18.
Ulus Travma Acil Cerrahi Derg ; 14(1): 10-3, 2008 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-18306061

RESUMO

The number of trauma victims in Turkey is expected to increase as a consequence of the increasing vehicular traffic, potential for earthquakes, and risk of terrorist attacks. The Turkish Association for Trauma and Emergency Surgery monitors trauma cases, publishes a quarterly journal, organizes trauma courses and seminars for various health personnel nationwide. It is also extending efforts to improve in-hospital care by establishing trauma and emergency surgery fellowships and trauma and emergency surgery centers nationwide, which is run by General Surgeons currently. Turkey faces the same dilemma as the rest of the developed world regarding the future of trauma surgeons in the current era of nonoperative trauma management. We suggest that the field of trauma and emergency surgery be redefined to include emergency general surgery and cavitary trauma.


Assuntos
Tratamento de Emergência , Necessidades e Demandas de Serviços de Saúde , Traumatologia/tendências , Serviço Hospitalar de Emergência/tendências , Humanos , Centro Cirúrgico Hospitalar/tendências , Turquia
19.
Ulus Travma Acil Cerrahi Derg ; 14(4): 318-22, 2008 Oct.
Artigo em Turco | MEDLINE | ID: mdl-18988057

RESUMO

BACKGROUND: The aim of this study was to evaluate demographics, methodological data and writing style of abstracts presented at the 5th Congress of National Trauma and Emergency Surgery. METHODS: Study design, institutions and number of authors, appropriateness of the title, use of a structured abstract, word count, fluency, accuracy of the statistical evaluation, and conclusionabstract accordance were assessed in 451 abstracts. RESULTS: Nearly 49% of abstracts were retrospective and 29% were case reports in design. 33%, 26%, and 24% of abstracts were related to isolated organ, single system and multi-system injuries, respectively. Approximately two-fifths of presentations were university-based. Approximately one-third of presentations were multidisciplinary in origin. The mean number of authors was 5.6+/-1.8, and a statistical significance was found between abstract contributions from university versus other hospitals (p=0.001). Three-fourths of the abstracts had an appropriate title and 91% were structured. Word count was 100-250 in 57% and 250-500 in 42% of abstracts. Statistical analysis was used in only 19% of abstracts. Most of the abstracts were fluent. Conclusion-abstract accordance was present in 71% of the abstracts. CONCLUSION: Our results indicate there are some deficiencies in the abstract writing process. The use of a structured abstract may intensify fluency and compliance to abstract writing guidelines. Clinical studies regarding multi-traumatized patient groups and experimental studies should be encouraged.


Assuntos
Indexação e Redação de Resumos/estatística & dados numéricos , Congressos como Assunto , Projetos de Pesquisa/estatística & dados numéricos , Redação/normas , Indexação e Redação de Resumos/métodos , Indexação e Redação de Resumos/normas , Estudos de Casos e Controles , Humanos , Estudos Prospectivos , Pesquisa , Projetos de Pesquisa/normas , Estudos Retrospectivos
20.
Ulus Travma Acil Cerrahi Derg ; 24(1): 20-24, 2018 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-29350363

RESUMO

BACKGROUND: Fatigue and sleep deprivation can affect rational decision-making and motor skills, which can decrease medical performance and quality of patient care. The aim of the present study was to investigate the association between times of the day when laparoscopic general surgery under general anesthesia was performed and their adverse outcomes. METHODS: All laparoscopic cholecystectomies and appendectomies performed at the emergency surgery department of a tertiary university hospital from 01. 01. 2016 to 12. 31. 2016 were included. Operation times were divided into three groups: 08.01-17.00 (G1: daytime), 17.01-23.00 (G2: early after-hours), and 23.01-08.00 (G3: nighttime). The files of the included patients were evaluated for intraoperative and postoperative surgery and anesthesia-related complications. RESULTS: We used multiple regression analyses of variance with the occurrence of intraoperative complications as a dependent variable and comorbidities, age, gender, body mass index (BMI), ASA score, and operation time group as independent variables. This revealed that nighttime operation (p<0.001; OR, 6.7; CI, 2.6-16.9) and older age (p=0.004; OR, 1.04; CI, 1.01-1.08) were the risk factor for intraoperative complications. The same analysis was performed for determining a risk factor for postoperative complications, and none of the dependent variables were found to be associated with the occurrence of postoperative complications. CONCLUSION: Nighttime surgery and older patient age increased the risk of intraoperative complications without serious morbidity or mortality, but no association was observed between the independent variables and the occurrence of postoperative complications.


Assuntos
Anestesia Geral , Colecistectomia Laparoscópica/estatística & dados numéricos , Competência Clínica , Avaliação de Resultados em Cuidados de Saúde , Complicações Pós-Operatórias/epidemiologia , Adulto , Colecistectomia Laparoscópica/efeitos adversos , Feminino , Humanos , Masculino , Duração da Cirurgia , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/mortalidade , Estudos Retrospectivos , Fatores de Risco , Fatores de Tempo , Turquia/epidemiologia
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