Long-term follow up of paediatric liver transplant recipients: outcomes following transfer to adult healthcare in New Zealand.

Poor outcomes are reported in young people with chronic health conditions. We performed a retrospective notes review of New Zealand paediatric liver transplant recipients transferred to adult services. Two patients were lost to follow up. Out of 20, 12 were non-adherent, and out of 12, 7 developed rejection. Other risk behaviours were common in the non-adherent group. We conclude that dedicated services for these young people may be needed to optimise outcomes.

Hodgkin disease relapse discovered at the time of liver transplant for acute liver failure.

Lymphoma is a recognized cause of liver damage and in rare instances presents as ALF. In such cases, the underlying malignancy is often difficult to detect. Historically, the prognosis has been poor. Cure has occasionally been achieved with chemotherapy alone. LT in this setting is controversial, but has contributed to successful outcomes, as in the case of the five-yr-old girl reported here.

Affirming the existential within medicine: medical humanities, governance, and imaginative understanding.

This paper first distinguishes governance (collective, autonomous self-regulatory processes) from government (externally-imposed mandatory regulation); it proposes that the second of these is essentially incompatible with a conception of the medical humanities that involves imagination and vision on the part of medical practitioners. It next develops that conception of the medical humanities, as having three distinguishable aspects (all of them distinct from the separate phenomena popularly known as "arts-in-health"): first, an intellectual enquiry into the nature of clinical medicine; second, an important dimension of medical education; third, a resource for moral and aesthetic influences upon clinical practice, supporting "humane health care" as the moral inspirations behind organised medicine. Medical humanities sustains these three aspects through paying proper attention to the existential and subjective aspects of medicine. By encouraging authentic imagination among health care practitioners, medical humanities aligns well with both humane health care and governance in the sense of self-regulation. However, it can neither be achieved mechanistically nor well-measured through proxies such as patient satisfaction. Above all, it should not be allowed to supply, through inappropriate qualitative "targets," new forms of management tyranny.

Medicine and music: three relations considered.

Two well-recognised, but inherently reductionist, relations between medicine and music are the attempted neuro-scientific understanding of responses to music and interest in music's contributions to clinical therapy. This paper proposes a third relation whereby music is seen as an organising metaphor for clinical medicine as a practice. Both music and clinical medicine affirm human well-being, and both do this inter alia through varieties of skilful, crafted yet spontaneous mutual engagement between a 'performer' and an 'audience'. I argue that this organising metaphor offers a corrective to the reductionist influences of the first two relations, illuminates a number of medicine's important features, and reaffirms the existential as being at the core of medicine's telos.

Wonder and the patient.

Is it possible to distinguish, as sociologist Arthur Frank proposes, an 'ideal of wonder' within which ill persons could recover some of their former sense of life and flourishing, even within the constraints of ill-health? Beyond this, are there more general benefits in terms of health and well-being that could accrue from cultivating an openness to wonder? In this paper I will first outline and defend a notion of wonder that gives philosophical support to Frank's proposal, noting why thinking about medical treatment may readily provoke a sense of wonder. Second I will however limit the normative force of such an 'ideal of wonder' noting its demands and some of the challenges facing it. The paper goes on, third, to conjecture wider benefits within and beyond the clinical encounter arising from being mindful of the wonder of embodied human agency. Fourth the paper will consider alignments between the foregoing analysis and some theoretical commitments in recent work in health geography. Finally I will briefly reconsider the notion of the body-as-territory, and the role of the imagination in bringing it under wonder's gaze.

Cortical neuronal counts in normal elderly controls and demented patients.

The purposes of the investigation were to determine whether there was significant neuronal loss in dementia, and if so, whether it was general or localised, and to examine the relationship between neuronal counts, senile plaques and neurofibrillary change. Neuronal counts were made in nine cortical areas in the brains of 25 patients with senile dementia of the Alzheimer type and twenty-five age-matched controls, with the aid of an image analysing computer. Neuronal counts per square millimetre were significantly lower in the demented group of patients in the inferior frontal and superior temporal gyri. Neuronal counts in four columns of cortex were significantly reduced in superior, middle and inferior frontal gyri, cingulate gyrus and superior and middle temporal gyri. There was no significant difference in the parietal (Brodmann area 7) or occipital (Brodmann area 17) cortex. Corresponding glial counts per square millimetre show a significant increase in the demented group only in the middle and inferior temporal gyri. Neuronal counts correlated weakly but significantly with plaque counts in the same cortical area in the middle frontal gyrus and the superior and middle temporal gyri. High correlations between neuronal counts and estimates of neurofibrillary change were found in superior, middle and inferior frontal gyri, cingulate gyrus and superior and middle temporal gyri.

Foundation-level dyslexia: assessment and treatment.

It is supposed that there is an early, foundation stage in beginning reading during which children acquire basic letter-sound knowledge, a capability for alphabetic processing, and a logographic sight vocabulary. An assessment of foundation processes was administered to Scottish children with reading difficulties (n = 51) and to reading-level-matched controls (n = 56). The results suggested that the foundation is normally in place by the time a reading age of about 7 years has been achieved. Foundation-level dyslexia is identifiable in children with reading difficulty whose reading ages fall below this level. Differing patterns of dyslexia were observed, depending on whether the primary effect was on letter-sound learning (literal dyslexia), the acquisition of the alphabetic process (alphabetic dyslexia), or retention of a sight vocabulary (logographic dyslexia). Balanced dyslexia, in which both alphabetic and logographic functions were impaired, was also found. Some implications for assessment and treatment are discussed.

Wonder and the clinical encounter.

In terms of intervening in embodied experience, medical treatment is wonder-full in its ambition and its metaphysical presumption; yet, wonder's role in clinical medicine has received little philosophical attention. In this paper, I propose, to doctors and others in routine clinical life, the value of an openness to wonder and to the sense of wonder. Key to this is the identity of the central ethical challenges facing most clinicians, which is not the high-tech drama of the popular conceptions of medical ethics but, rather, the routine of patients' undramatic but unremitting demands for the clinician's time and respectful attention. Wonder (conceived as an intense and transfiguring attentiveness) is a ubiquitous ethical source, an alternative to the more familiar respect for rational autonomy, a source of renewal galvanizing diagnostic imagination, and a timely recalling of the embodied agency of both patient and clinician.

Multiple joint involvement in total knee replacement for osteoarthritis: Effects on patient-reported outcomes.

OBJECTIVE: To determine whether symptomatic (painful/problematic) joints pre-total knee replacement (TKR) surgery influence 1) pre- and 12-month post-TKR patient-reported outcomes (pain, physical function, and mood [fatigue, anxiety, and depression]) and 2) postsurgical pain and function mediated through mood. METHODS: A total of 494 participants completed the patient-reported outcome measures pre- and 12-months post-TKR. Symptomatic (painful/problematic) joints affected by arthritis were indicated on a homunculus presurgery. Covariate data included age, sex, educational attainment, body mass index, and comorbidity. Pre- and postsurgical outcome scores were regressed on symptomatic joint sites and covariates using linear regression analyses; postsurgical scores additionally were regressed on presurgery scores. Path analyses examined whether the effects of symptomatic joint sites on postsurgical pain and function were mediated through mood. RESULTS: The age range was 35-88 years (mean 65 years) and 65% were women. Forty-six percent reported ≥4 symptomatic joints (other than the surgical knee). Pre- and postsurgery, worse outcome scores were observed with increasing joint count. Adjusted for covariates, individuals reporting symptomatic ankles/feet/toes, neck, and spine/lower back had worse presurgery fatigue and anxiety. Adjusted for covariates and presurgery status, worse fatigue for the neck and spine/lower back and worse depression, pain, and function for the ankles/feet/toes and neck were observed postsurgery. The influence of symptomatic ankles/feet/toes on postsurgical pain and function was in part direct and partially mediated through depression. Full mediation was found for the neck through fatigue, anxiety, and depression, and for the spine/lower back through fatigue. CONCLUSION: Findings suggest that a comprehensive approach to osteoarthritis management/care is warranted, and identify important associations between symptomatic joints and mood that negatively impact post-TKR pain and physical function.

A HISTORY OF THE THEORY OF PRENATAL ATTACHMENT.

John Bowlby's theory of human attachment has become widely applied across disciplines and across the stages of human development. This discussion explores the evolution of an application of Bowlby's theory to the experience of pregnancy, from both maternal and paternal perspectives. Although the theoretical construct of maternal fetal attachment (MFA) requires continued theoretically-driven research, existing studies have associated this proposed construct with health behaviors, marital relationship, depressive symptoms, and the postpartum mother-infant relationship, pointing toward its relevance for academicians and clinicians devoted to the service of women and infants.

Development of the Texas Spanish Naming Test: a test for Spanish speakers.

Neuropsychological assessment of Spanish speakers often involves translated versions of English measures, with limited validation data and potential bias due to cultural, educational, and linguistic differences. The Texas Spanish Naming Test (TNT), a 30-item confrontation naming test, was developed for Spanish speakers by systematically selecting culturally salient words. In a sample of 85 minimally educated Spanish speakers, the TNT demonstrated good internal consistency and convergent validity, and showed greater sensitivity than a translated version of the popular Boston Naming Test. Results support the clinical utility of the TNT when dementia among Spanish speakers is suspected.

Do patients have duties?

The notion of patients' duties has received periodic scholarly attention but remains overwhelmed by attention to the duties of healthcare professionals. In a previous paper the author argued that patients in publicly funded healthcare systems have a duty to participate in clinical research, arising from their debt to previous patients. Here the author proposes a greatly extended range of patients' duties grounding their moral force distinctively in the interests of contemporary and future patients, since medical treatment offered to one patient is always liable to be an opportunity cost (however justifiable) in terms of medical treatment needed by other patients. This generates both negative and positive duties. Ten duties-enjoining obligations ranging from participation in healthcare schemes to promoting one's own earliest recovery from illness-are proposed. The characteristics of these duties, including their basis, moral force, extent and enforceability, are considered. They are tested against a range of objections-principled, societal, epistemological and practical-and found to survive. Finally, the paper suggests that these duties could be thought to reinforce a regrettably adversarial characteristic, shared with rights-based approaches, and that a preferable alternative might be sought through the (here unexplored) notion of a "virtuous patient" contributing to a problem-solving partnership with the clinician. However, in defining and giving content to that partnership, there is a clear role for most, if not all, of the proposed duties; their value thus extends beyond the adversarial context in which they might first be thought to arise.

Medical humanities: stranger at the gate, or long-lost friend?

"Medical humanities" is a phrase whose currency is wider than its agreed meaning or denotation. What sort of study is it, and what is its relation to the study of philosophy of medicine? This paper briefly reviews the origins of the current flowering of interest and activity in studies that are collectively called "medical humanities", and presents an account of its nature and central enquiries in which philosophical questions are unashamedly central. In the process this paper argues that the field of enquiry is well-conceived as being philosophical in character, and as having philosophy - albeit pursued over a larger canvas - at the core of its contributing humanities disciplines. The paper characterises humanities disciplines as having an important focus on human experience and subjectivity, of which the experiences and subjectivities at stake in health, medicine and illness form an important sub-set, the preoccupation of the medical humanities as a whole. Claims of interdisciplinarity (as distinct from multidisciplinarity) are noted, but such claims need to be recognised for the high and stern ambition that they embody, and should not be made lightly.

Uncomfortable implications: placebo equivalence in drug management of a functional illness.

Using a fictional but representative general practice consultation, involving the diagnosis of irritable bowel syndrome in a patient who is anxious for some relief from the discomfort his condition entails, this paper argues that when both (a) a drug fails to out-perform placebo and (b) the condition in question is a functional illness with no demonstrable underlying pathology, then the action of the drug is not only no better than placebo, and it is also no different from it either. The paper also argues that, in the circumstances of the consultation described, it is striking that current governance deems it ethical for a practitioner to prescribe either a drug or a placebo, both of which appear to rely for their effectiveness on a measure of concealment on the part of the doctor, yet deems it unethical for a practitioner openly to prescribe a harmless and enjoyable substance which (in equivalent conditions of transparency and information) is likely to be no less effective than either drug or placebo and is also likely to be better-tolerated and cheaper than the drug.

Cause for concern: the absence of consideration of public and ethical interest in British public policy.

In the UK, many fundamentally important policy decisions that are likely to affect the relationship between citizens and care services are now made at the sublegislative level and without adequate ethical consideration and scrutiny. This is well exemplified in the proposed guidance on the disclosure of information on children. A recent consultation paper by the UK government on the subject proposes an approach that seeks a simple technical solution to a complex problem, emphasising control and surveillance. This reflects pressure to be seen to act. The document fails with regard to ethical reflection appropriate to the complexity of the issue, an appreciation of complex relationships of trust, and a proper sense of the richness and complexity of the public interest. Such policies would, if implemented, fundamentally change the relationships between citizens and their carers, and among carers and the law and the state. This and similar proposals require far more ethical scrutiny and consideration of the public interest in the widest sense.