Detalhe da pesquisa
1.
CrossTORC and WNTegration in Disease: Focus on Lymphangioleiomyomatosis.
Int J Mol Sci
; 22(5)2021 Feb 24.
Artigo
Inglês
| MEDLINE | ID: mdl-33668092
2.
Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis.
J Pharmacol Exp Ther
; 360(1): 1-13, 2017 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-27754931
3.
Structural Basis for Inhibition of Human Autotaxin by Four Potent Compounds with Distinct Modes of Binding.
Mol Pharmacol
; 88(6): 982-92, 2015 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-26371182
4.
Syndecan-2: Old Player in a New Field.
Am J Respir Cell Mol Biol
; 60(6): 611-612, 2019 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-30896971
5.
International Union of Basic and Clinical Pharmacology. LXXXIV: leukotriene receptor nomenclature, distribution, and pathophysiological functions.
Pharmacol Rev
; 63(3): 539-84, 2011 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-21771892
6.
Pharmacodynamics, pharmacokinetics and safety of GSK2190915, a novel oral anti-inflammatory 5-lipoxygenase-activating protein inhibitor.
Br J Clin Pharmacol
; 75(3): 779-90, 2013 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-22803688
7.
Lost in translation: a neglected mTOR target for lymphangioleiomyomatosis.
Eur Respir Rev
; 32(169)2023 Sep 30.
Artigo
Inglês
| MEDLINE | ID: mdl-37758276
8.
DP2 (CRTh2) antagonism reduces ocular inflammation induced by allergen challenge and respiratory syncytial virus.
Int Arch Allergy Immunol
; 157(3): 259-68, 2012.
Artigo
Inglês
| MEDLINE | ID: mdl-22042170
9.
Evaluation of endo- and exo-aryl-substitutions and central scaffold modifications on diphenyl substituted alkanes as 5-lipoxygenase activating protein inhibitors.
Bioorg Med Chem Lett
; 22(12): 4133-8, 2012 Jun 15.
Artigo
Inglês
| MEDLINE | ID: mdl-22578458
10.
Pharmacology of AM211, a potent and selective prostaglandin D2 receptor type 2 antagonist that is active in animal models of allergic inflammation.
J Pharmacol Exp Ther
; 338(1): 290-301, 2011 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-21487069
11.
Discovery and optimization of a biphenylacetic acid series of prostaglandin D2 receptor DP2 antagonists with efficacy in a murine model of allergic rhinitis.
Bioorg Med Chem Lett
; 21(21): 6608-12, 2011 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21958540
12.
Sodium [2'-[(cyclopropanecarbonyl-ethyl-amino)-methyl]-4'-(6-ethoxy-pyridin-3-yl)-6-methoxy-biphenyl-3-yl]-acetate (AM432): a potent, selective prostaglandin D2 receptor antagonist.
Bioorg Med Chem Lett
; 21(3): 1036-40, 2011 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21211969
13.
The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm.
Nat Med
; 10(9): 966-73, 2004 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-15322539
14.
Effects of prolactin on TSC2-null Eker rat cells and in pulmonary lymphangioleiomyomatosis.
Am J Respir Crit Care Med
; 182(4): 531-9, 2010 Aug 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20413627
15.
The nuclear membrane organization of leukotriene synthesis.
Proc Natl Acad Sci U S A
; 105(51): 20434-9, 2008 Dec 23.
Artigo
Inglês
| MEDLINE | ID: mdl-19075240
16.
Pharmacological blockade of the DP2 receptor inhibits cigarette smoke-induced inflammation, mucus cell metaplasia, and epithelial hyperplasia in the mouse lung.
J Pharmacol Exp Ther
; 332(3): 764-75, 2010 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-19996299
17.
5-Lipoxygenase-activating protein inhibitors. Part 3: 3-{3-tert-Butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM643)-A potent FLAP inhibitor suitable for topical administration.
Bioorg Med Chem Lett
; 20(15): 4598-601, 2010 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20566292
18.
5-Lipoxygenase-activating protein inhibitors. Part 2: 3-{5-((S)-1-Acetyl-2,3-dihydro-1H-indol-2-ylmethoxy)-3-tert-butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-1H-indol-2-yl}-2,2-dimethyl-propionic acid (AM679)--a potent FLAP inhibitor.
Bioorg Med Chem Lett
; 20(1): 213-7, 2010 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19914828
19.
Montelukast Use Decreases Cardiovascular Events in Asthmatics.
Front Pharmacol
; 11: 611561, 2020.
Artigo
Inglês
| MEDLINE | ID: mdl-33519477
20.
mTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function decline.
Nat Commun
; 11(1): 5640, 2020 11 06.
Artigo
Inglês
| MEDLINE | ID: mdl-33159078