Detalhe da pesquisa
1.
Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis.
J Pharmacol Exp Ther
; 360(1): 1-13, 2017 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-27754931
2.
Structural Basis for Inhibition of Human Autotaxin by Four Potent Compounds with Distinct Modes of Binding.
Mol Pharmacol
; 88(6): 982-92, 2015 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-26371182
3.
International Union of Basic and Clinical Pharmacology. LXXXIV: leukotriene receptor nomenclature, distribution, and pathophysiological functions.
Pharmacol Rev
; 63(3): 539-84, 2011 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-21771892
4.
Pharmacodynamics, pharmacokinetics and safety of GSK2190915, a novel oral anti-inflammatory 5-lipoxygenase-activating protein inhibitor.
Br J Clin Pharmacol
; 75(3): 779-90, 2013 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-22803688
5.
Lost in translation: a neglected mTOR target for lymphangioleiomyomatosis.
Eur Respir Rev
; 32(169)2023 Sep 30.
Artigo
Inglês
| MEDLINE | ID: mdl-37758276
6.
DP2 (CRTh2) antagonism reduces ocular inflammation induced by allergen challenge and respiratory syncytial virus.
Int Arch Allergy Immunol
; 157(3): 259-68, 2012.
Artigo
Inglês
| MEDLINE | ID: mdl-22042170
7.
Pharmacology of AM211, a potent and selective prostaglandin D2 receptor type 2 antagonist that is active in animal models of allergic inflammation.
J Pharmacol Exp Ther
; 338(1): 290-301, 2011 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-21487069
8.
Discovery and optimization of a biphenylacetic acid series of prostaglandin D2 receptor DP2 antagonists with efficacy in a murine model of allergic rhinitis.
Bioorg Med Chem Lett
; 21(21): 6608-12, 2011 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21958540
9.
Sodium [2'-[(cyclopropanecarbonyl-ethyl-amino)-methyl]-4'-(6-ethoxy-pyridin-3-yl)-6-methoxy-biphenyl-3-yl]-acetate (AM432): a potent, selective prostaglandin D2 receptor antagonist.
Bioorg Med Chem Lett
; 21(3): 1036-40, 2011 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21211969
10.
The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm.
Nat Med
; 10(9): 966-73, 2004 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-15322539
11.
Effects of prolactin on TSC2-null Eker rat cells and in pulmonary lymphangioleiomyomatosis.
Am J Respir Crit Care Med
; 182(4): 531-9, 2010 Aug 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20413627
12.
The nuclear membrane organization of leukotriene synthesis.
Proc Natl Acad Sci U S A
; 105(51): 20434-9, 2008 Dec 23.
Artigo
Inglês
| MEDLINE | ID: mdl-19075240
13.
Pharmacological blockade of the DP2 receptor inhibits cigarette smoke-induced inflammation, mucus cell metaplasia, and epithelial hyperplasia in the mouse lung.
J Pharmacol Exp Ther
; 332(3): 764-75, 2010 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-19996299
14.
5-Lipoxygenase-activating protein inhibitors. Part 3: 3-{3-tert-Butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM643)-A potent FLAP inhibitor suitable for topical administration.
Bioorg Med Chem Lett
; 20(15): 4598-601, 2010 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20566292
15.
5-Lipoxygenase-activating protein inhibitors. Part 2: 3-{5-((S)-1-Acetyl-2,3-dihydro-1H-indol-2-ylmethoxy)-3-tert-butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-1H-indol-2-yl}-2,2-dimethyl-propionic acid (AM679)--a potent FLAP inhibitor.
Bioorg Med Chem Lett
; 20(1): 213-7, 2010 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19914828
16.
Montelukast Use Decreases Cardiovascular Events in Asthmatics.
Front Pharmacol
; 11: 611561, 2020.
Artigo
Inglês
| MEDLINE | ID: mdl-33519477
17.
mTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function decline.
Nat Commun
; 11(1): 5640, 2020 11 06.
Artigo
Inglês
| MEDLINE | ID: mdl-33159078
18.
What's all the FLAP about?: 5-lipoxygenase-activating protein inhibitors for inflammatory diseases.
Trends Pharmacol Sci
; 29(2): 72-8, 2008 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-18187210
19.
Pharmacological characterization of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103), a novel selective 5-lipoxygenase-activating protein inhibitor that reduces acute and chronic inflammation.
J Pharmacol Exp Ther
; 331(3): 1042-50, 2009 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-19749079
20.
Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine model of allergic rhinitis.
Bioorg Med Chem Lett
; 19(16): 4647-51, 2009 Aug 15.
Artigo
Inglês
| MEDLINE | ID: mdl-19608418