RESUMO
A new alloplastic high-permeable material based on tricalcium phosphate with Kelvin architectonics created by stereolithographic 3D-printing was studied in vivo. A monocortical defect of the femur was modeled in rats and the material was implanted into the defect area. In 24 weeks, the animals were euthanized and histological examination of the defect area was performed. One femur fracture with fixator migration was recorded after implantation of the studied material and the reference chronOS synthetic material. The studied material demonstrated better osteoconductive properties then traditional osteoplastic material, which was seen from greater number of bone trabeculae and their area in the defect area.
Assuntos
Regeneração Óssea/fisiologia , Substitutos Ósseos/uso terapêutico , Osso Esponjoso/crescimento & desenvolvimento , Diáfises/anormalidades , Fêmur/anormalidades , Animais , Transplante Ósseo/métodos , Fosfatos de Cálcio/uso terapêutico , Diáfises/patologia , Modelos Animais de Doenças , Fêmur/patologia , Porosidade , Impressão Tridimensional , Ratos , Ratos WistarRESUMO
The objective of the present study was to identify morphological features of stab and slush injuries to the skin inflicted with the ragged-spine knife. Visual and stereoscopic examination of experimental skin injuries to the biodummies revealed a number of peculiar characteristics of such wounds. Their severity is shown to depend on such factors as pressure on the spine or the blade.
Assuntos
Pele , Ferimentos Perfurantes/patologia , Patologia Legal/métodos , Humanos , Pele/lesões , Pele/patologia , Índices de Gravidade do Trauma , Armas/classificaçãoRESUMO
A technique for colloidal forming of Ca2P2O7 macroporous bioceramics, based on low-pressure injection molding (LPIM) of a glycerol-water slip containing Ca2P2O7 and Ca(Ð2PO4)2 into a plastic mold fabricated via FDM 3D-printing, was proposed. Chemical reaction between the solid phases of the water containing slip - Ca2P2O7 and Ca(Ð2PO4)2, resulting in brushite (CaHPO4·2H2O) formation, led to consolidation of the casting and preserved its complex architecture in the course of mold burning-out. Macroporous ceramics of Kelvin structure (70% macropores with the sizes from 2 up to 4 mm), based on a pre-defined composition with 10 wt% Ca(PO3)2 and sintered in liquid-phase regime, demonstrated a compressive strength of 1.4 ± 0.1 MPa at a density of 22 ± 2%. In vitro tests on bioactivity in SBF solution, as well as on resorption of the ceramics in model solution of citric acid, were carried out.