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Clin Immunol ; 181: 60-66, 2017 08.
Artigo em Inglês | MEDLINE | ID: mdl-28625884

RESUMO

Anecdotal case reports, amplified by mass media and internet-based opinion groups, have recently indicated vaccinations as possibly responsible for autoimmunity/lymphoproliferation development. Multiply vaccinated Italian military personnel (group 1, operating in Italy, group 2, operating in Lebanon) were followed-up for nine months to monitor possible post-vaccine autoimmunity/lymphoproliferation onset. No serious adverse event was noticed in both groups. Multivariate analysis of intergroup differences only showed a significant association between lymphocyte increase and tetanus/diphtheria vaccine administration. A significant post-vaccine decrease in autoantibody positivity was observed. Autoantibodies were also studied by microarray analysis of self-proteins in subjects exposed to ≥4 concurrent vaccinations, without observing significant difference among baseline and one and nine months post-vaccine. Moreover, HLA-A2 subjects have been analyzed for the possible CD8T-cell response to apoptotic self-epitopes, without observing significant difference between baseline and one month post-vaccine. Multiple vaccinations in young adults are safe and not associated to autoimmunity/lymphoproliferation onset during a nine-month-long follow-up.


Assuntos
Doenças Autoimunes/epidemiologia , Transtornos Linfoproliferativos/epidemiologia , Militares/estatística & dados numéricos , Vacinas/uso terapêutico , Adolescente , Adulto , Anticorpos Anticitoplasma de Neutrófilos/imunologia , Anticorpos Antinucleares/imunologia , Anticorpos Antifosfolipídeos/imunologia , Autoanticorpos/imunologia , Doenças Autoimunes/imunologia , Eletroforese das Proteínas Sanguíneas , Vacina contra Varicela/uso terapêutico , Vacina contra Difteria e Tétano/uso terapêutico , Feminino , Seguimentos , Vacinas contra Hepatite A/uso terapêutico , Vacinas contra Hepatite B/uso terapêutico , Humanos , Imunoglobulinas/sangue , Vacinas contra Influenza/uso terapêutico , Itália/epidemiologia , Transtornos Linfoproliferativos/imunologia , Masculino , Vacina contra Sarampo-Caxumba-Rubéola/uso terapêutico , Vacinas Meningocócicas/uso terapêutico , Vacina Antipólio de Vírus Inativado/uso terapêutico , Estudos Prospectivos , Fator Reumatoide/imunologia , Fatores de Risco , Vacinas Tíficas-Paratíficas/uso terapêutico , Adulto Jovem
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