RESUMO
Titanium (Ti) and its alloys are the most commonly used materials for bone implants. However, implant failure often happens due to bacterial infection. Developing antibacterial coatings on Ti implants is an effective strategy. Dopamine and tannic acid were cross-linked to form coating on Ti through Michael addition and Schiff base reaction. In addition, the Ag ions were grafted on the coating by the redox reaction of phenolic hydroxyl groups. Thus, an Ag-incorporated polydopamine/tannic acid coating was prepared on Ti substrate. SEM, EDS, water contact angle, FTIR, and XRD results demonstrated that the coating was formed on Ti successfully. The antibacterial activity of the coating against Gram-negative E. coli was examined, and the cytotoxicity of the coating was investigated by mouse fibroblast cells. The improvement of hydrophilicity, good cytocompatibility, and antibacterial effectiveness indicates that the coating has potential to surface modification of Ti implants.
RESUMO
Porous titanium was modified by anodic oxidation and heat treatment method. Scanning electron microscopy and X-ray diffraction examinations revealed that the modified surface of porous titanium was covered by anatase nanotubes. In vitro, the bioactivity of specimens before and after modification was evaluated by immersing into the double-concentration simulated body fluid for 7 days. The porous titanium specimens were implanted into the femurs of dogs for 3 months. The osteointegration of the implants was investigated by push-out test and histological examination. The results showed that the porous titanium with anatase nanotubes has the superior ability of apatite formation and a higher push-out force when compared with the other implants. The histological analysis indicated that the implant with anatase nanotubes had excellent ability to facilitate the osteointegration in vivo.