Detalhe da pesquisa
1.
Reconstitution of the Alzheimer's Disease Tau Core Structure from Recombinant Tau297-391 Yields Variable Quaternary Structures as Seen by Negative Stain and Cryo-EM.
Biochemistry
; 63(2): 194-201, 2024 Jan 16.
Artigo
Inglês
| MEDLINE | ID: mdl-38154792
2.
Tau protein liquid-liquid phase separation can initiate tau aggregation.
EMBO J
; 37(7)2018 04 03.
Artigo
Inglês
| MEDLINE | ID: mdl-29472250
3.
A flow cytometry-based in vitro assay reveals that formation of apolipoprotein E (ApoE)-amyloid beta complexes depends on ApoE isoform and cell type.
J Biol Chem
; 293(34): 13247-13256, 2018 08 24.
Artigo
Inglês
| MEDLINE | ID: mdl-29950521
4.
Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity.
EMBO J
; 34(24): 3028-41, 2015 Dec 14.
Artigo
Inglês
| MEDLINE | ID: mdl-26538322
5.
Isoform- and cell type-specific structure of apolipoprotein E lipoparticles as revealed by a novel Forster resonance energy transfer assay.
J Biol Chem
; 292(36): 14720-14729, 2017 09 08.
Artigo
Inglês
| MEDLINE | ID: mdl-28684412
6.
Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients.
Ann Neurol
; 80(3): 355-67, 2016 09.
Artigo
Inglês
| MEDLINE | ID: mdl-27351289
7.
Formation, release, and internalization of stable tau oligomers in cells.
J Neurochem
; 139(6): 1163-1174, 2016 12.
Artigo
Inglês
| MEDLINE | ID: mdl-27731899
8.
Real-time imaging of mitochondrial redox reveals increased mitochondrial oxidative stress associated with amyloid ß aggregates in vivo in a mouse model of Alzheimer's disease.
Mol Neurodegener
; 19(1): 6, 2024 Jan 18.
Artigo
Inglês
| MEDLINE | ID: mdl-38238819
9.
Distinct dendritic spine and nuclear phases of calcineurin activation after exposure to amyloid-ß revealed by a novel fluorescence resonance energy transfer assay.
J Neurosci
; 32(15): 5298-309, 2012 Apr 11.
Artigo
Inglês
| MEDLINE | ID: mdl-22496575
10.
Inhibition of the NFAT pathway alleviates amyloid ß neurotoxicity in a mouse model of Alzheimer's disease.
J Neurosci
; 32(9): 3176-92, 2012 Feb 29.
Artigo
Inglês
| MEDLINE | ID: mdl-22378890
11.
Specific detection of tau seeding activity in Alzheimer's disease using rationally designed biosensor cells.
Mol Neurodegener
; 18(1): 53, 2023 08 08.
Artigo
Inglês
| MEDLINE | ID: mdl-37553663
12.
Distinct roles in vivo for the ubiquitin-proteasome system and the autophagy-lysosomal pathway in the degradation of α-synuclein.
J Neurosci
; 31(41): 14508-20, 2011 Oct 12.
Artigo
Inglês
| MEDLINE | ID: mdl-21994367
13.
Characterization of oligomer formation of amyloid-beta peptide using a split-luciferase complementation assay.
J Biol Chem
; 286(31): 27081-91, 2011 Aug 05.
Artigo
Inglês
| MEDLINE | ID: mdl-21652708
14.
Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation.
J Neurosci
; 30(7): 2636-49, 2010 Feb 17.
Artigo
Inglês
| MEDLINE | ID: mdl-20164348
15.
Conformational fingerprinting of tau variants and strains by Raman spectroscopy.
RSC Adv
; 11(15): 8899-8915, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-34381596
16.
Isoform-selective decrease of glycogen synthase kinase-3-beta (GSK-3ß) reduces synaptic tau phosphorylation, transcellular spreading, and aggregation.
iScience
; 24(2): 102058, 2021 Feb 19.
Artigo
Inglês
| MEDLINE | ID: mdl-33554064
17.
An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of α-synuclein.
Cell Rep
; 35(10): 109189, 2021 06 08.
Artigo
Inglês
| MEDLINE | ID: mdl-34107263
18.
Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer's disease.
Nat Commun
; 11(1): 2146, 2020 05 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32358564
19.
Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease.
J Neuropathol Exp Neurol
; 68(5): 515-24, 2009 May.
Artigo
Inglês
| MEDLINE | ID: mdl-19525899
20.
Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport.
J Neurochem
; 111(2): 417-27, 2009 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-19686388