Detalhe da pesquisa
1.
Orally bioavailable amine-linked macrocyclic inhibitors of factor XIa.
Bioorg Med Chem Lett
; 30(4): 126949, 2020 02 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31932224
2.
Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability.
Bioorg Med Chem Lett
; 29(19): 126604, 2019 10 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31445854
3.
Macrocyclic inhibitors of Factor XIa: Discovery of alkyl-substituted macrocyclic amide linkers with improved potency.
Bioorg Med Chem Lett
; 27(16): 3833-3839, 2017 08 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28687203
4.
Orally bioavailable pyridine and pyrimidine-based Factor XIa inhibitors: Discovery of the methyl N-phenyl carbamate P2 prime group.
Bioorg Med Chem
; 24(10): 2257-72, 2016 05 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27073051
5.
Pyridine and pyridinone-based factor XIa inhibitors.
Bioorg Med Chem Lett
; 25(4): 925-30, 2015 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-25592713
6.
Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties.
Bioorg Med Chem Lett
; 25(7): 1635-42, 2015 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-25728130
7.
Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy.
J Med Chem
; 65(3): 1770-1785, 2022 02 10.
Artigo
Inglês
| MEDLINE | ID: mdl-34494428
8.
Discovery of a High Affinity, Orally Bioavailable Macrocyclic FXIa Inhibitor with Antithrombotic Activity in Preclinical Species.
J Med Chem
; 63(13): 7226-7242, 2020 07 09.
Artigo
Inglês
| MEDLINE | ID: mdl-32456431
9.
Potent, Orally Bioavailable, and Efficacious Macrocyclic Inhibitors of Factor XIa. Discovery of Pyridine-Based Macrocycles Possessing Phenylazole Carboxamide P1 Groups.
J Med Chem
; 63(2): 784-803, 2020 01 23.
Artigo
Inglês
| MEDLINE | ID: mdl-31833761
10.
Structure-activity relationships of anthranilamide-based factor Xa inhibitors containing piperidinone and pyridinone P4 moieties.
Bioorg Med Chem Lett
; 18(9): 2845-9, 2008 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-18424044
11.
Structure-Based Design of Macrocyclic Factor XIa Inhibitors: Discovery of the Macrocyclic Amide Linker.
J Med Chem
; 60(3): 1060-1075, 2017 02 09.
Artigo
Inglês
| MEDLINE | ID: mdl-28085275
12.
Asymmetric synthesis of substituted prolines from delta-amino beta-ketoesters. Methyl (2S,5R)-(+)-5-phenylpyrrolidine-2-carboxylate.
Org Lett
; 4(9): 1599-602, 2002 May 02.
Artigo
Inglês
| MEDLINE | ID: mdl-11975638
13.
Asymmetric Synthesis of 2H-Azirine 2-Carboxylate Esters.
J Org Chem
; 64(24): 8929-8935, 1999 Nov 26.
Artigo
Inglês
| MEDLINE | ID: mdl-11674800
14.
Characterization of a new class of selective nonsteroidal progesterone receptor agonists.
Steroids
; 69(3): 201-17, 2004 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-15072922
15.
Phenylimidazoles as potent and selective inhibitors of coagulation factor XIa with in vivo antithrombotic activity.
J Med Chem
; 57(23): 9915-32, 2014 Dec 11.
Artigo
Inglês
| MEDLINE | ID: mdl-25405503