Detalhe da pesquisa
1.
Transcriptional coactivator PGC-1α contains a novel CBP80-binding motif that orchestrates efficient target gene expression.
Genes Dev
; 32(7-8): 555-567, 2018 04 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29654059
2.
Biocatalytic Strategy for the Highly Stereoselective Synthesis of Fluorinated Cyclopropanes.
Angew Chem Int Ed Engl
; : e202406779, 2024 May 16.
Artigo
Inglês
| MEDLINE | ID: mdl-38752612
3.
Enantioselective Single and Dual α-C-H Bond Functionalization of Cyclic Amines via Enzymatic Carbene Transfer.
J Am Chem Soc
; 145(1): 537-550, 2023 01 11.
Artigo
Inglês
| MEDLINE | ID: mdl-36542059
4.
Dehaloperoxidase Catalyzed Stereoselective Synthesis of Cyclopropanol Esters.
J Org Chem
; 88(12): 7630-7640, 2023 Jun 16.
Artigo
Inglês
| MEDLINE | ID: mdl-36542602
5.
Tuning Enzyme Thermostability via Computationally Guided Covalent Stapling and Structural Basis of Enhanced Stabilization.
Biochemistry
; 2022 May 25.
Artigo
Inglês
| MEDLINE | ID: mdl-35612958
6.
Cyclic peptides with a distinct arginine-fork motif recognize the HIV trans-activation response RNA in vitro and in cells.
J Biol Chem
; 297(6): 101390, 2021 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34767799
7.
Enantioselective Synthesis of α-Trifluoromethyl Amines via Biocatalytic N-H Bond Insertion with Acceptor-Acceptor Carbene Donors.
J Am Chem Soc
; 144(6): 2590-2602, 2022 02 16.
Artigo
Inglês
| MEDLINE | ID: mdl-35107997
8.
Co-crystal structures of HIV TAR RNA bound to lab-evolved proteins show key roles for arginine relevant to the design of cyclic peptide TAR inhibitors.
J Biol Chem
; 295(49): 16470-16486, 2020 12 04.
Artigo
Inglês
| MEDLINE | ID: mdl-33051202
9.
A Diverse Library of Chiral Cyclopropane Scaffolds via Chemoenzymatic Assembly and Diversification of Cyclopropyl Ketones.
J Am Chem Soc
; 143(5): 2221-2231, 2021 02 10.
Artigo
Inglês
| MEDLINE | ID: mdl-33497207
10.
Biocatalytic Strategy for the Highly Stereoselective Synthesis of CHF2 -Containing Trisubstituted Cyclopropanes.
Angew Chem Int Ed Engl
; 60(13): 7072-7076, 2021 03 22.
Artigo
Inglês
| MEDLINE | ID: mdl-33337576
11.
Mechanism-Guided Design and Discovery of Efficient Cytochrome P450-Derived C-H Amination Biocatalysts.
J Am Chem Soc
; 142(23): 10343-10357, 2020 06 10.
Artigo
Inglês
| MEDLINE | ID: mdl-32407077
12.
C-H Amination via Nitrene Transfer Catalyzed by Mononuclear Non-Heme Iron-Dependent Enzymes.
Chembiochem
; 21(14): 1981-1987, 2020 07 16.
Artigo
Inglês
| MEDLINE | ID: mdl-32189465
13.
Organic solvent stability and long-term storage of myoglobin-based carbene transfer biocatalysts.
Biotechnol Appl Biochem
; 67(4): 516-526, 2020 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-32542734
14.
Enzyme stabilization via computationally guided protein stapling.
Proc Natl Acad Sci U S A
; 114(47): 12472-12477, 2017 11 21.
Artigo
Inglês
| MEDLINE | ID: mdl-29109284
15.
An Enzymatic Platform for the Highly Enantioselective and Stereodivergent Construction of Cyclopropyl-δ-lactones.
Angew Chem Int Ed Engl
; 59(48): 21634-21639, 2020 11 23.
Artigo
Inglês
| MEDLINE | ID: mdl-32667122
16.
Stereodivergent Intramolecular Cyclopropanation Enabled by Engineered Carbene Transferases.
J Am Chem Soc
; 141(23): 9145-9150, 2019 06 12.
Artigo
Inglês
| MEDLINE | ID: mdl-31099569
17.
Effect of proximal ligand substitutions on the carbene and nitrene transferase activity of myoglobin.
Tetrahedron
; 75(16): 2357-2363, 2019 04 19.
Artigo
Inglês
| MEDLINE | ID: mdl-31133770
18.
Biocatalytic Strategy for Highly Diastereo- and Enantioselective Synthesis of 2,3-Dihydrobenzofuran-Based Tricyclic Scaffolds.
Angew Chem Int Ed Engl
; 58(30): 10148-10152, 2019 07 22.
Artigo
Inglês
| MEDLINE | ID: mdl-31099936
19.
Cyclopropanations via Heme Carbenes: Basic Mechanism and Effects of Carbene Substituent, Protein Axial Ligand, and Porphyrin Substitution.
J Am Chem Soc
; 140(5): 1649-1662, 2018 02 07.
Artigo
Inglês
| MEDLINE | ID: mdl-29268614
20.
Stabilization of the Reductase Domain in the Catalytically Self-Sufficient Cytochrome P450BM3 by Consensus-Guided Mutagenesis.
Chembiochem
; 19(6): 622-632, 2018 03 16.
Artigo
Inglês
| MEDLINE | ID: mdl-29276819