RESUMO
The effect of diets containing soybean proteins substituting a significant portion of meat proteins was studied in patients with hyperlipidemia, type IIa, and in experiments on rats. It was found that soybean proteins included into the diet induced blood plasma amino acid imbalance, changed the excretion of some amino acids with urine, and significantly diminished the blood plasma cholesterol level. In the experiments on rats a reduced rate was noted in the low-density lipoprotein apoprotein formation and high-density lipoprotein apoprotein regeneration in the blood plasma. It is suggested that the hypocholesterolemic effect of soybean proteins is caused by decreased apoprotein E synthesis and metabolism due to low levels of blood plasma lysine and arginine.
Assuntos
Anticolesterolemiantes , Proteínas Alimentares/uso terapêutico , Glycine max , Proteínas de Plantas/uso terapêutico , Adulto , Aminoácidos/análise , Animais , Apolipoproteínas/sangue , HDL-Colesterol/sangue , LDL-Colesterol/sangue , Doença das Coronárias/dietoterapia , Doença das Coronárias/metabolismo , Avaliação de Medicamentos , Avaliação Pré-Clínica de Medicamentos , Meia-Vida , Humanos , Hiperlipoproteinemia Tipo II/dietoterapia , Hiperlipoproteinemia Tipo II/metabolismo , Masculino , Pessoa de Meia-Idade , Ratos , Ratos EndogâmicosRESUMO
The pre- and postflight biochemical analyses of the blood of 16 cosmonauts flown aboard Mir orbital station over 125-366 days revealed the changes in carbohydrate, lipid and protein metabolism being in line with the present-day ideas about the space flight effects on the human metabolism. A particular individual pattern of the responses and the absence of correlation with flight duration of space expeditions ranging from 4 months to a 1 year, are noted.