Rituximab in the treatment of primary cutaneous B-cell lymphoma: a review.

Rituximab is a chimeric mouse-human antibody that targets the CD20 antigen, which is found in both normal and neoplastic B cells. In recent years, it has been increasingly used to treat cutaneous B-cell lymphoma and is now considered an alternative to classic treatment (radiotherapy and surgery) of 2 types of indolent lymphoma, namely, primary cutaneous follicle center lymphoma and primary cutaneous marginal zone B-cell lymphoma. Rituximab is also administered as an alternative to polychemotherapy in the treatment of primary cutaneous large B-cell lymphoma, leg type. Its use as an alternative drug led to it being administered intralesionally, with beneficial effects. In the present article, we review the literature published on the use of rituximab to treat primary cutaneous B-cell lymphoma.

Rituximab en el tratamiento de los linfomas cutáneos B primarios: revisión / Rituximab in the Treatment of Primary Cutaneous B-Cell Lymphoma: A Review

Rituximab es un anticuerpo quimérico murino-humano dirigido contra el antígeno CD20 presente en los linfocitos B normales y neoplásicos. Su uso en los linfomas cutáneos de células B ha ido en creciente desarrollo en los últimos años. Así se plantea como una alternativa a los tratamientos clásicos de radioterapia y cirugía en los linfomas de curso indolente, el linfoma folicular y el linfoma de la zona marginal. También se utiliza en el tratamiento del linfoma cutáneo primario de células grandes tipo piernas como alternativa a la poliquimioterapia. Su desarrollo como alternativa terapéutica ha llevado a su uso intralesional también con buenos resultados. En este artículo se revisa la literatura publicada del uso de rituximab en los linfomas cutáneos primarios de células B

Rituximab is a chimeric mouse-human antibody that targets the CD20 antigen, which is found in both normal and neoplastic B cells. In recent years, it has been increasingly used to treat cutaneous B-cell lymphoma and is now considered an alternative to classic treatment (radiotherapy and surgery) of 2 types of indolent lymphoma, namely, primary cutaneous follicle center lymphoma and primary cutaneous marginal zone B-cell lymphoma. Rituximab is also administered as an alternative to polychemotherapy in the treatment of primary cutaneous large B-cell lymphoma, leg type. Its use as an alternative drug led to it being administered intralesionally, with beneficial effects. In the present article, we review the literature published on the use of rituximab to treat primary cutaneous B-cell lymphoma