Allopurinol for fibromyalgia pain in adults: A randomized controlled trial.

BACKGROUND: Allopurinol is a potent inhibitor of the enzyme xanthine oxidase used in the treatment of hyperuricemia and gout. Because it is well known that purines exert multiple affects on pain transmission, we hypothesized that the inhibition of xanthine oxidase by allopurinol could be a valid strategy to treat pain in humans. This study aimed to compare the analgesic efficacy of oral allopurinol versus placebo as an adjuvant therapy in patients displaying fibromyalgia. METHODS: This randomized, double-blinded, placebo-controlled study included 60 women with the diagnosis of fibromyalgia. Patients were randomly assigned to receive either oral allopurinol 300 mg (n = 31) or placebo (n = 29) twice daily during 30 days. The patients were submitted to evaluation for pain sensitivity, anxiety, depression, and functional status before treatment, and 15 and 30 days thereafter. RESULTS: Oral administration of allopurinol 300 mg twice daily was ineffective in improving pain scores measured by several tools up to 30 days of treatment (P > 0.05). Additionally, no significant effects of allopurinol over anxiety, depressive symptoms, and functional status of fibromyalgia patients were observed in the present study. CONCLUSIONS: Although previous findings indicated that allopurinol could present intrinsic analgesic effects in both animals and humans, this study showed no benefit of the use of oral allopurinol as an adjuvant strategy during 30 days in women displaying fibromyalgia. However, considering previous promising results, new prospective studies are still valid to further investigate allopurinol and more selective purine derivatives in the management of pain syndromes.

Pneumonia during the first two years of life does not increase risk of respiratory infections in preschool children.

SUMMARY OBJECTIVES: To investigate the relationship between severe pneumonia during the first two years of life and subsequent respiratory infections in preschool children. METHODS: This was a cross-sectional study. We interviewed parents of children who were classified as exposed (n = 36) or non-exposed (n = 84), based on whether they were hospitalized with radiologically-confirmed pneumonia during the first two years of life. The main outcomes were physician-diagnosed respiratory infections (acute otitis media, pharyngitis, and pneumonia) and use of antibiotics during the last 2 and 12 months. RESULTS: There were no significant differences between two groups in terms of prevalence of acute otitis media, pharyngitis, pneumonia and use of antibiotics during the last 2 months (5.9 vs 6.2%, 14.3 vs 26.0%, 0.0 vs 1.2% and 36.7 vs 38.7% respectively; P > 0.05 for all comparisons) and during the last 12 months (20.6 vs 18.5%, 40.0 vs 45.5%, 2.8 vs 2.4% and 76.7 vs 77.3% respectively; P > 0.05 for all comparisons). CONCLUSIONS: Pneumonia severe enough to require hospitalization during the first two years of life does not increase the risk of respiratory infections in preschool children.