Detalhe da pesquisa
1.
JNJ-10450232 (NTM-006), A novel non-opioid with structural similarities to acetaminophen, produces relatively long-lasting analgesia after a single dose in patients undergoing 3rd molar extraction.
Regul Toxicol Pharmacol
; : 105480, 2023 Aug 23.
Artigo
Inglês
| MEDLINE | ID: mdl-37625518
2.
Preclinical safety assessment of JNJ-10450232 (NTM-006), a structural analog of acetaminophen, that does not cause hepatotoxicity at supratherapeutic doses.
Regul Toxicol Pharmacol
; : 105334, 2023 Jan 04.
Artigo
Inglês
| MEDLINE | ID: mdl-36608923
3.
Metabolism and disposition of JNJ-10450232 (NTM-006) in rats, dogs, monkeys and humans.
Regul Toxicol Pharmacol
; : 105379, 2023 Mar 16.
Artigo
Inglês
| MEDLINE | ID: mdl-36931586
4.
First-in-human study to evaluate the safety, tolerability and pharmacokinetics of a novel analgesic and antipyretic drug with structural similarity to acetaminophen.
Regul Toxicol Pharmacol
; 134: 105236, 2022 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-35934140
5.
Pharmacologic Characterization of JNJ-42226314, [1-(4-Fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a Reversible, Selective, and Potent Monoacylglycerol Lipase Inhibitor.
J Pharmacol Exp Ther
; 372(3): 339-353, 2020 03.
Artigo
Inglês
| MEDLINE | ID: mdl-31818916
6.
The discovery of diazetidinyl diamides as potent and reversible inhibitors of monoacylglycerol lipase (MAGL).
Bioorg Med Chem Lett
; 30(12): 127198, 2020 06 15.
Artigo
Inglês
| MEDLINE | ID: mdl-32334914
7.
The discovery of azetidine-piperazine di-amides as potent, selective and reversible monoacylglycerol lipase (MAGL) inhibitors.
Bioorg Med Chem Lett
; 30(14): 127243, 2020 07 15.
Artigo
Inglês
| MEDLINE | ID: mdl-32527545
8.
Discovery and optimization of a novel series of pyrazolyltetrahydropyran N-type calcium channel (Cav 2.2) blockers for the treatment of pain.
Bioorg Med Chem Lett
; 28(23-24): 3780-3783, 2018 12 15.
Artigo
Inglês
| MEDLINE | ID: mdl-30337231
9.
Characterization of the trigeminovascular actions of several adenosine A2A receptor antagonists in an in vivo rat model of migraine.
J Headache Pain
; 19(1): 41, 2018 May 25.
Artigo
Inglês
| MEDLINE | ID: mdl-29802484
10.
Global deletion of MGL in mice delays lipid absorption and alters energy homeostasis and diet-induced obesity.
J Lipid Res
; 56(6): 1153-71, 2015 06.
Artigo
Inglês
| MEDLINE | ID: mdl-25842377
11.
Erratum: Global deletion of MGL in mice delays lipid absorption and alters energy homeostasis and diet-induced obesity.
J Lipid Res
; 60(3): 717, 2019 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-30824679
12.
Transient receptor potential melastatin 8 channel inhibition potentiates the hypothermic response to transient receptor potential vanilloid 1 activation in the conscious mouse.
Crit Care Med
; 42(5): e355-63, 2014 May.
Artigo
Inglês
| MEDLINE | ID: mdl-24595220
13.
Discovery and SAR of novel tetrahydropyrrolo[3,4-c]pyrazoles as inhibitors of the N-type calcium channel.
Bioorg Med Chem Lett
; 24(9): 2053-6, 2014 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24726802
14.
Discovery and SAR of a novel series of 2,4,5,6-tetrahydrocyclopenta[c]pyrazoles as N-type calcium channel inhibitors.
Bioorg Med Chem Lett
; 24(9): 2057-61, 2014 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24726803
15.
Shivering and tachycardic responses to external cooling in mice are substantially suppressed by TRPV1 activation but not by TRPM8 inhibition.
Am J Physiol Regul Integr Comp Physiol
; 305(9): R1040-50, 2013 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24005250
16.
Arylglycine derivatives as potent transient receptor potential melastatin 8 (TRPM8) antagonists.
Bioorg Med Chem Lett
; 23(7): 2234-7, 2013 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23411075
17.
Discovery of vinylcycloalkyl-substituted benzimidazole TRPM8 antagonists effective in the treatment of cold allodynia.
Bioorg Med Chem Lett
; 22(5): 1903-7, 2012 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22330635
18.
A novel series of pyrazolylpiperidine N-type calcium channel blockers.
Bioorg Med Chem Lett
; 22(12): 4080-3, 2012 Jun 15.
Artigo
Inglês
| MEDLINE | ID: mdl-22608964
19.
The design and synthesis of novel, phosphonate-containing transient receptor potential melastatin 8 (TRPM8) antagonists.
Bioorg Med Chem Lett
; 22(8): 2922-6, 2012 Apr 15.
Artigo
Inglês
| MEDLINE | ID: mdl-22421018
20.
Revealing Unknown Benefits of Existing Medications to Aid the Discovery of New Treatments for Post-Traumatic Stress Disorder.
Psychiatr Res Clin Pract
; 4(1): 12-20, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-36101715