Detalhe da pesquisa
1.
Modification of Cysteine-Substituted Antibodies Using Enzymatic Oxidative Coupling Reactions.
Bioconjug Chem
; 34(3): 510-517, 2023 03 15.
Artigo
Inglês
| MEDLINE | ID: mdl-36787347
2.
Novel antibody-antibiotic conjugate eliminates intracellular S. aureus.
Nature
; 527(7578): 323-8, 2015 Nov 19.
Artigo
Inglês
| MEDLINE | ID: mdl-26536114
3.
Structure-guided design of a selective BCL-X(L) inhibitor.
Nat Chem Biol
; 9(6): 390-7, 2013 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-23603658
4.
Learning and confirming with preclinical studies: modeling and simulation in the discovery of GDC-0917, an inhibitor of apoptosis proteins antagonist.
Drug Metab Dispos
; 41(12): 2104-13, 2013 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-24041744
5.
In vivo bioluminescence imaging of labile iron in xenograft models and liver using FeAL-1, an iron-activatable form of D-luciferin.
Cell Chem Biol
; 30(11): 1468-1477.e6, 2023 11 16.
Artigo
Inglês
| MEDLINE | ID: mdl-37820725
6.
Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres.
Bioorg Med Chem Lett
; 20(7): 2229-33, 2010 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20189383
7.
Discovery of A-1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL-XL Inhibitor.
ACS Med Chem Lett
; 11(10): 1829-1836, 2020 Oct 08.
Artigo
Inglês
| MEDLINE | ID: mdl-33062160
8.
Cyclodextrin Reduces Intravenous Toxicity of a Model Compound.
J Pharm Sci
; 108(6): 1934-1943, 2019 06.
Artigo
Inglês
| MEDLINE | ID: mdl-30639736
9.
Discovery of Peptidomimetic Antibody-Drug Conjugate Linkers with Enhanced Protease Specificity.
J Med Chem
; 61(3): 989-1000, 2018 02 08.
Artigo
Inglês
| MEDLINE | ID: mdl-29227683
10.
Activity-based probes for the ubiquitin conjugation-deconjugation machinery: new chemistries, new tools, and new insights.
FEBS J
; 284(10): 1555-1576, 2017 05.
Artigo
Inglês
| MEDLINE | ID: mdl-28196299
11.
Activity-based probes for the multicatalytic proteasome.
FEBS J
; 284(10): 1540-1554, 2017 05.
Artigo
Inglês
| MEDLINE | ID: mdl-28107776
12.
Decoupling stability and release in disulfide bonds with antibody-small molecule conjugates.
Chem Sci
; 8(1): 366-370, 2017 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28451181
13.
Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers.
J Med Chem
; 60(23): 9490-9507, 2017 12 14.
Artigo
Inglês
| MEDLINE | ID: mdl-29112410
14.
Modulating Therapeutic Activity and Toxicity of Pyrrolobenzodiazepine Antibody-Drug Conjugates with Self-Immolative Disulfide Linkers.
Mol Cancer Ther
; 16(5): 871-878, 2017 05.
Artigo
Inglês
| MEDLINE | ID: mdl-28223423
15.
Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates.
Nat Chem
; 8(12): 1112-1119, 2016 12.
Artigo
Inglês
| MEDLINE | ID: mdl-27874860
16.
Development of novel drugs targeting inhibitors of apoptosis.
Future Oncol
; 5(2): 141-4, 2009 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-19284370
17.
Inhibiting caspase-6 activation and catalytic activity for neurodegenerative diseases.
Curr Top Med Chem
; 14(3): 319-25, 2014.
Artigo
Inglês
| MEDLINE | ID: mdl-24283214
18.
Site-specific trastuzumab maytansinoid antibody-drug conjugates with improved therapeutic activity through linker and antibody engineering.
J Med Chem
; 57(19): 7890-9, 2014 Oct 09.
Artigo
Inglês
| MEDLINE | ID: mdl-25191794
19.
Structure-Guided Rescaffolding of Selective Antagonists of BCL-XL.
ACS Med Chem Lett
; 5(6): 662-7, 2014 Jun 12.
Artigo
Inglês
| MEDLINE | ID: mdl-24944740
20.
Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.
ACS Med Chem Lett
; 5(10): 1088-93, 2014 Oct 09.
Artigo
Inglês
| MEDLINE | ID: mdl-25313317