RESUMO
A patient with antibodies to human T-cell leukemia virus type I and the presence of integrated sequences of this virus in T-lymphocytes was investigated. In contrast to previous reports, the T-cell lymphocytosis was found to be polyclonal by analysis of human T-cell leukemia virus type I integration sites and T-cell antigen receptor rearrangements. Polyclonal T-cell infection by human T-cell leukemia virus type I may represent an infrequently observed stage of leukemogenesis.
Assuntos
Deltaretrovirus/genética , Linfocitose/microbiologia , Linfócitos T/microbiologia , Idoso , DNA Viral/análise , Infecções por Deltaretrovirus/complicações , Feminino , Humanos , Isotipos de Imunoglobulinas/análise , Leucemia/etiologia , Linfocitose/imunologia , Provírus/genética , Receptores de Antígenos de Linfócitos T/genéticaRESUMO
Activation antigens expressed by activated B cells, but not by resting B cells, are excellent candidate molecules for lymphokine receptors, which are expressed after B cell activation. HC2 is a previously described hairy cell leukemia associated antigen, which is not expressed by chronic lymphocytic leukemia B cells. HC2 is also found on activated B cells but not on resting B cells. Here we demonstrate that HC2 is not a B lineage restricted antigen and may be expressed by other activated cell types. Antibody to HC2 inhibits the activity of partially purified B cell growth factor in two different assays and inhibits B cell differentiation induced by pokeweed mitogen or Staphylococcus aureus Cowan stain I with interleukin-2. The HC2 antigen may therefore have a distinct role in normal B cell differentiation.