High ultrasensitive serum C-reactive protein may be related to freezing of gait in Parkinson's disease patients.

C-reactive protein (CRP) is a biomarker of systemic inflammation that has been linked to accelerated decline in walking speed in older adults. The aim of the present study was to compare the CRP levels of PD patients with vs patients without freezing of gait (FOG). Patients and controls participating in the COPPADIS-2015 study that performed blood extraction for determining molecular serum biomarkers were included. Patients with FOG were identified as those with a score of 1 or greater on item-3 of the Freezing of Gait Questionnaire (FOG-Q). Immunoassay was used for determining ultrasensitive CRP (US-CRP) level (mg/dL). In the PD group (n = 225; 61.8 ± 9.5 years old, 61.8% males), 32% of the patients presented FOG but none in the control group (n = 65; 60.3 ± 6.1 years old, 56.9% males) (p < 0.0001). Differences in US-CRP level were significant in patients with FOG vs patients without FOG and vs controls (0.31 ± 0.52 vs 0.16 ± 0.21 vs 0.21 ± 0.22; p = 0.04). Significant differences were also observed between patients with vs without FOG (p = 0.001) but not between patients and controls (p = 0.163). US-CRP level was related to FOG (OR = 4.369; 95% CI 1.105-17.275; p = 0.036) along with H&Y (OR = 2.974; 95% CI 1.113-7.943; p = 0.030) and non-motor symptoms burden (NMSS total score; OR = 1.017; 95% CI 1.005-1.029; p = 0.006) after adjusting for age, gender, disease duration, equivalent daily levodopa dose, number of non-antiparkinsonian drugs per day, motor fluctuations, cognition, motor phenotype, and chronic use of anti-inflammatory drugs. The present study suggests that serum US-CRP level is related to FOG in PD patients. Inflammation could be linked to FOG development.

Non-motor symptoms burden, mood, and gait problems are the most significant factors contributing to a poor quality of life in non-demented Parkinson's disease patients: Results from the COPPADIS Study Cohort.

OBJECTIVE: To identify factors related to a poor health-related and global quality of life (QoL) in a cohort of non-demented Parkinson's disease (PD) patients and compare to a control group. METHODS: The data correspond to the baseline evaluation of the COPPADIS-2015 Study, an observational, 5-year follow-up, multicenter, evaluation study. Three instruments were used to assess QoL: (1) the 39-item Parkinson's disease Questionnaire (PDQ-39), (2) a subjective rating of global QoL (PQ-10), and (3) the EUROHIS-QOL 8-item index (EUROHIS-QOL8). Multiple linear regression methods were used to evaluate the direct impact of different variables on these QoL measures. RESULTS: QoL was worse in PD patients (n = 692; 62.6 ±â€¯8.9 years old, 60.3% males) than controls (n = 206; 61 ±â€¯8.3 years old, 49.5% males): PDQ-39, 17.1 ±â€¯13.5 vs 4.4 ±â€¯6.3 (p < 0.0001); PQ-10, 7.3 ±â€¯1.6 vs 8.1 ±â€¯1.2 (p < 0.0001); EUROHIS-QOL8, 3.8 ±â€¯0.6 vs 4.2 ±â€¯0.5 (p < 0.0001). A high correlation was observed between PDQ-39 and Non-Motor Symptoms Scale (NMSS) (r = 0.72; p < 0.0001), and PDQ-39 and Beck Depression Inventory-II (BDI-II) (r = 0.65; p < 0.0001). For health-related QoL (PDQ-39), non-motor symptoms burden (NMSS), mood (BDI-II), and gait problems (Freezing Of Gait Questionnaire [FOGQ]) provided the highest contribution to the model (ß = 0.32, 0.28, and 0.27, respectively; p < 0.0001); whereas mood and gait problems contributed the most to global QoL (PQ-10, ß = -0.46 and -0.21, respectively; EUROHIS-QOL8, ß = -0.44 and -0.23, respectively). CONCLUSIONS: QoL is worse in PD patients than in controls. Mood, non-motor symptoms burden, and gait problems seem to be the most relevant factors affecting health-related and global perceived QoL in non-demented PD patients.

[Epidemiological study on chronic renal failure elderly patients on hemodialysis]. / Estudio epidemiológico de pacientes ancianos con insuficiencia renal crónica en hemodiálisis.

Hemodialysis shows an increased prevalence in elderly patients, a population which often presents poor nutrition, high prevalence of cardiovascular, neurological and osteoarticular diseases and psycho-social problems. The objective of this epidemiological, cross-sectional and multicenter study, in patients older than 65 years (n 625) and >75 years (n 558) from 29 Spanish medical institutions was to perform an epidemiological analysis It included demographic information, as well as data regarding chronic renal failure, functional and psychological abilities (Katz Index, Lawton and Karnofsky Scales), dialysis logistics and clinical parameters. The study analyzed data from 1,183 patients (678 female), mean age 75.4+/-5.5 years; mean duration of dialysis 4.3+/-5.1 years (57.7% were referred by the GP: general practitioner). The most frequent etiologies were diabetic nephropathy (21.2%) and vascular renal disease (20.9%). The main comorbilites were high blood pressure (75.6%), Diabetes Mellitus (32.9%) and vascular (29.0%) and osteoarticular (27.3%) diseases. The great majority of patients lived at their family home (85.0%), travelled to their dialysis units alone (80.8%) and by ambulance (56.7%), and it took them less than an hour to arrive (87.5%). Over 75% of patients were fully functional (79.4% under 75 years and 71.6% over 75); meanwhile 10.5% were partially impaired and 13,8% severely impaired. Karnofsky performance scale scored less than 70 in 59.4% of the patients. Analytical parameters rated Hb >or= 11 g/dL for 81.7% of patients; ferritin >or= 100 ng/dL for 98.5%; PTH 150-300 pg/mL for 31.9%; albumin >3.5 g/dL for 75.6%; and serum phosphor <5.5 mg/dL for 70.6%. For the dialysis Kt/V the mean value was 1.4+/-0.3 with a mean duration of dialysis session of 11.7+/-4.0 hours/week. High permeability membranes were used in 52.3% of patients and internal arteriovenous fistula in 74.0%. Around 75% of elderly patients on hemodialysis fulfill age-suitable daily living activities and display adequate dialysis quality parameters.

Estudio epidemiológico de pacientes ancianos con insuficiencia renal crónica en hemodiálisis / Epidemiological study on chronic renal failure elderly patients on hemodialysis

Los ancianos, una población cada vez más prevalente en hemodiálisis, suelen presentar mal estado nutricional, alta prevalencia de enfermedades cardiovasculares, neurológicas y osteoarticulares, y problemas psicosociales. Este trabajo analiza descriptivamente la epidemiología de esta población, mediante un estudio multicéntrico epidemiológico transversal de 1.183 pacientes en 29 centros españoles con pacientes mayores de 65 (n 625) y mayores de 75 años (n 558) en hemodiálisis. En él se examinan parámetros demográficos, relativos a la insuficiencia renal crónica (IRC), valoración cognitiva- funcional (índice de Katz, Karnofsky y escala Lawton), aspectos logísticos y parámetros analíticos. 678 fueron mujeres La media de edad fue de 75,4 ± 5,5, y 4,3 ± 5,1 años desde el diagnóstico de IRC al inicio de la hemodiálisis, y el 57,7% fue remitido por el médico de familia. Las etiologías más frecuentes fueron: nefropatía diabética (21,2%) y enfermedad vascular renal (20,9%). En las comorbilidades se halló hipertensión arterial (75,6%), Diabetes Mellitus (32,9%), enfermedad vascular (29,0%) y osteoarticular (27,3%). La gran mayoría de los pacientes vivían en un domicilio familiar fijo (85,0%), acudían solos (80,8%) y en ambulancia (56,7%) a diálisis, y tardaban menos de 1 h en llegar a sus centros (87,5%). Más del 75,0% de los pacientes se encontraban en pleno funcionamiento (el 79,4% de los menores de 75 años y años el 71,6% de los mayores de 75), un 13,8% presentaban un deterioro funcional severo, y el 10,5% restante un deterioro moderado. En el análisis de la valoración cognitiva-funcional, el 59,4% de los pacientes presentaron un Karnofsky menor de 70. En la analítica, el porcentaje de pacientes con Hb ≥ 11 g/dL era del 81,7%; con ferritina sérica ≥ 100 ng/dL del 98,5%; con PTH 150-300 pg/mL del 31,9%; con albúmina > 3,5 g/dL del 75,6%; y con fósforo sérico < 5,5 mg/d del 70,6%. En la diálisis mostraron una media de Kt/V 1,4 ± 0,3 y de 11,7 ± 4 horas de tiempo de diálisis. Hubo uso de membranas de alta permeabilidad en el 52,3%, y el 74,0% de los pacientes utilizaron fístula arteriovenosa interna. Un 75% de los pacientes ancianos en hemodiálisis desarrollan actividades de la vida diaria normales para su edad, con parámetros adecuados de calidad de diálisis (AU)

Hemodialysis shows an increased prevalence in elderly patients, a population which often presents poor nutrition, high prevalence of cardiovascular, neurological and osteoarticular diseases and psycho-social problems. The objective of this epidemiological, cross-sectional and multicenter study, in patients older than 65 years (n 625) and > 75 years (n 558) from 29 Spanish medical institutions was to perform an epidemiological analysis It included demographic information, as well as data regarding chronic renal failure, functional and psychological abilities (Katz Index, Lawton and Karnofsky Scales), dialysis logistics and clinical parameters. The study analyzed data from 1,183 patients (678 female), mean age 75,4 ± 5,5 years; mean duration of dialysis 4,3 ± 5,1 years (57,7% were referred by the GP: general practitioner). The most frequent etiologies were diabetic nephropathy (21,2%) and vascular renal disease (20,9%). The main comorbilites were high blood pressure (75,6%), Diabetes Mellitus (32,9%) and vascular (29,0%) and osteoarticular (27,3%) diseases. The great majority of patients lived at their family home (85,0%), travelled to their dialysis units alone (80,8%) and by ambulance (56,7%), and it took them less than an hour to arrive (87,5%). Over 75% of patients were fully functional (79,4% under 75 years and 71,6% over 75); meanwhile 10,5% were partially impaired and 13,8% severely impaired. Karnofsky performance scale scored less than 70 in 59,4% of the patients. Analytical parameters rated Hb ≥ 11 g/dL for 81,7% of patients; ferritin ≥ 100 ng/dL for 98,5%; PTH 150-300 pg/mL for 31,9%; albumin > 3,5 g/dL for 75,6%; and serum phosphor < 5,5 mg/dL for 70,6%. For the dialysis Kt/V the mean value was 1,4 ± 0,3 with a mean duration of dialysis session of 11,7 ± 4,0 hours/week. High permeability membranes were used in 52,3% of patients and internal arteriovenous fistula in 74,0%. Around 75% of elderly patients on hemodialysis fulfill age-suitable daily living activities and display adequate dialysis quality parameters (AU)