Detalhe da pesquisa
1.
Wolbachia depletion blocks transmission of lymphatic filariasis by preventing chitinase-dependent parasite exsheathment.
Proc Natl Acad Sci U S A
; 119(15): e2120003119, 2022 04 12.
Artigo
Inglês
| MEDLINE | ID: mdl-35377795
2.
AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis.
Proc Natl Acad Sci U S A
; 116(4): 1414-1419, 2019 01 22.
Artigo
Inglês
| MEDLINE | ID: mdl-30617067
3.
Albendazole and antibiotics synergize to deliver short-course anti-Wolbachia curative treatments in preclinical models of filariasis.
Proc Natl Acad Sci U S A
; 114(45): E9712-E9721, 2017 11 07.
Artigo
Inglês
| MEDLINE | ID: mdl-29078351
4.
Interdomain lateral gene transfer of an essential ferrochelatase gene in human parasitic nematodes.
Proc Natl Acad Sci U S A
; 110(19): 7748-53, 2013 May 07.
Artigo
Inglês
| MEDLINE | ID: mdl-23610429
5.
Wolbachia filarial interactions.
Cell Microbiol
; 15(4): 520-6, 2013 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-23210448
6.
Development of Pyrazolopyrimidine Anti-Wolbachia Agents for the Treatment of Filariasis.
ACS Med Chem Lett
; 12(9): 1421-1426, 2021 Sep 09.
Artigo
Inglês
| MEDLINE | ID: mdl-34527179
7.
Development of a High-Throughput Cytometric Screen to Identify Anti- Wolbachia Compounds: The Power of Public-Private Partnership.
SLAS Discov
; 24(5): 537-547, 2019 06.
Artigo
Inglês
| MEDLINE | ID: mdl-30958712
8.
Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity.
PLoS Negl Trop Dis
; 13(2): e0007159, 2019 02.
Artigo
Inglês
| MEDLINE | ID: mdl-30818326
9.
Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides.
Nat Commun
; 10(1): 11, 2019 01 02.
Artigo
Inglês
| MEDLINE | ID: mdl-30602718
10.
Preclinical development of an oral anti-Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis.
Sci Transl Med
; 11(483)2019 03 13.
Artigo
Inglês
| MEDLINE | ID: mdl-30867321
11.
Boron-Pleuromutilins as Anti- Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis.
J Med Chem
; 62(5): 2521-2540, 2019 03 14.
Artigo
Inglês
| MEDLINE | ID: mdl-30730745
12.
Combinations of registered drugs reduce treatment times required to deplete Wolbachia in the Litomosoides sigmodontis mouse model.
PLoS Negl Trop Dis
; 12(1): e0006116, 2018 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29300732
13.
Author Correction: Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis.
Sci Rep
; 8(1): 1384, 2018 01 18.
Artigo
Inglês
| MEDLINE | ID: mdl-29348597
14.
Corrigendum: Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis.
Sci Rep
; 8: 46934, 2018 Jan 08.
Artigo
Inglês
| MEDLINE | ID: mdl-29308790
15.
Identification and prioritization of novel anti-Wolbachia chemotypes from screening a 10,000-compound diversity library.
Sci Adv
; 3(9): eaao1551, 2017 09.
Artigo
Inglês
| MEDLINE | ID: mdl-28959730
16.
Comparison of Doxycycline, Minocycline, Doxycycline plus Albendazole and Albendazole Alone in Their Efficacy against Onchocerciasis in a Randomized, Open-Label, Pilot Trial.
PLoS Negl Trop Dis
; 11(1): e0005156, 2017 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28056021
17.
Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis.
Sci Rep
; 7(1): 210, 2017 03 16.
Artigo
Inglês
| MEDLINE | ID: mdl-28303006
18.
Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis.
Sci Rep
; 6: 23458, 2016 Mar 21.
Artigo
Inglês
| MEDLINE | ID: mdl-26996237
19.
Development and validation of a high-throughput anti-Wolbachia whole-cell screen: a route to macrofilaricidal drugs against onchocerciasis and lymphatic filariasis.
J Biomol Screen
; 20(1): 64-9, 2015 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-25278497
20.
Fit for purpose: do we have the right tools to sustain NTD elimination?
BMC Proc
; 9(Suppl 10): S5, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-28281703