1.
Bioorg Med Chem
; 4(5): 659-66, 1996 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-8804530
RESUMO
A novel scaffold system for the generation of diversity libraries has been designed which allows for rapid modification not only of functional groups, but their spatial arrangements as well. The biphenyl scaffold allows for display of three or four diverse functional groups in a wide variety of spatial arrangements depending on the substitution pattern selected. The libraries are generated by a combination of solution and solid-phase chemistries and are cleaved off the solid-support for screening.