1.
J Chromatogr A
; 944(1-2): 263-7, 2002 Jan 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11831761
RESUMO
The Mitsunobu reaction was used to attach tetra-O-benzyl-D-glucopyranose to a monoindolylmaleimide, providing a key intermediate in the total synthesis of indolocarbazole topoisomerase I poisons. Using normal-phase silica gel chromatography, purification of the glycosylated product normally required multiple columns, resulting in poor recovered yields. Reversed-phase chromatography was used successfully to purify this highly hydrophobic material, rapidly and in high yield.