Detalhe da pesquisa
1.
A saturation mutagenesis screen uncovers resistant and sensitizing secondary KRAS mutations to clinical KRASG12C inhibitors.
Proc Natl Acad Sci U S A
; 119(18): e2120512119, 2022 05 03.
Artigo
Inglês
| MEDLINE | ID: mdl-35471904
2.
Neuroconductor: an R platform for medical imaging analysis.
Biostatistics
; 20(2): 218-239, 2019 04 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29325029
3.
Harmonization of cortical thickness measurements across scanners and sites.
Neuroimage
; 167: 104-120, 2018 02 15.
Artigo
Inglês
| MEDLINE | ID: mdl-29155184
4.
Preprocessing, normalization and integration of the Illumina HumanMethylationEPIC array with minfi.
Bioinformatics
; 33(4): 558-560, 2017 02 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28035024
5.
Harmonization of multi-site diffusion tensor imaging data.
Neuroimage
; 161: 149-170, 2017 11 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28826946
6.
Corrigendum to: Neuroconductor: an R platform for medical imaging analysis.
Biostatistics
; 22(3): 685, 2021 Jul 17.
Artigo
Inglês
| MEDLINE | ID: mdl-32065220
7.
funtooNorm: an R package for normalization of DNA methylation data when there are multiple cell or tissue types.
Bioinformatics
; 32(4): 593-5, 2016 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-26500152
8.
Removing inter-subject technical variability in magnetic resonance imaging studies.
Neuroimage
; 132: 198-212, 2016 05 15.
Artigo
Inglês
| MEDLINE | ID: mdl-26923370
9.
A potentiator of orthosteric ligand activity at GLP-1R acts via covalent modification.
Nat Chem Biol
; 10(8): 629-31, 2014 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-24997604
10.
Cell-tethered ligands modulate bone remodeling by osteoblasts and osteoclasts.
Adv Funct Mater
; 24(4): 472-479, 2014 Jan 29.
Artigo
Inglês
| MEDLINE | ID: mdl-25419210
11.
Membrane tethered bursicon constructs as heterodimeric modulators of the Drosophila G protein-coupled receptor rickets.
Mol Pharmacol
; 83(4): 814-21, 2013 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-23340494
12.
Demonstration of the innate electrophilicity of 4-(3-(benzyloxy)phenyl)-2-(ethylsulfinyl)-6-(trifluoromethyl)pyrimidine (BETP), a small-molecule positive allosteric modulator of the glucagon-like peptide-1 receptor.
Drug Metab Dispos
; 41(8): 1470-9, 2013 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-23653442
13.
Chronic UCN2 treatment desensitizes CRHR2 and improves insulin sensitivity.
Nat Commun
; 14(1): 3953, 2023 07 04.
Artigo
Inglês
| MEDLINE | ID: mdl-37402735
14.
An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism.
Nat Commun
; 14(1): 5938, 2023 09 23.
Artigo
Inglês
| MEDLINE | ID: mdl-37741852
15.
Discovery of the Potent and Selective MC4R Antagonist PF-07258669 for the Potential Treatment of Appetite Loss.
J Med Chem
; 66(5): 3195-3211, 2023 03 09.
Artigo
Inglês
| MEDLINE | ID: mdl-36802610
16.
Membrane-tethered ligands are effective probes for exploring class B1 G protein-coupled receptor function.
Proc Natl Acad Sci U S A
; 106(19): 8049-54, 2009 May 12.
Artigo
Inglês
| MEDLINE | ID: mdl-19416829
17.
A comprehensive Bioconductor ecosystem for the design of CRISPR guide RNAs across nucleases and technologies.
Nat Commun
; 13(1): 6568, 2022 11 02.
Artigo
Inglês
| MEDLINE | ID: mdl-36323688
18.
Effector membrane translocation biosensors reveal G protein and ßarrestin coupling profiles of 100 therapeutically relevant GPCRs.
Elife
; 112022 03 18.
Artigo
Inglês
| MEDLINE | ID: mdl-35302493
19.
A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor.
J Med Chem
; 65(12): 8208-8226, 2022 06 23.
Artigo
Inglês
| MEDLINE | ID: mdl-35647711
20.
Roadmap for the use of base editors to decipher drug mechanism of action.
PLoS One
; 16(9): e0257537, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-34547052