Detalhe da pesquisa
1.
The large hydrophilic loop of presenilin 1 is important for regulating gamma-secretase complex assembly and dictating the amyloid beta peptide (Abeta) Profile without affecting Notch processing.
J Biol Chem
; 285(12): 8527-36, 2010 Mar 19.
Artigo
Inglês
| MEDLINE | ID: mdl-20106965
2.
Minor contribution of presenilin 2 for γ-secretase activity in mouse embryonic fibroblasts and adult mouse brain.
Biochem Biophys Res Commun
; 404(1): 564-8, 2011 Jan 07.
Artigo
Inglês
| MEDLINE | ID: mdl-21146496
3.
Affinity pulldown of γ-secretase and associated proteins from human and rat brain.
J Cell Mol Med
; 14(11): 2675-86, 2010 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-19754663
4.
Abeta43 is more frequent than Abeta40 in amyloid plaque cores from Alzheimer disease brains.
J Neurochem
; 110(2): 697-706, 2009 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-19457079
5.
Active gamma-secretase is localized to detergent-resistant membranes in human brain.
FEBS J
; 275(6): 1174-87, 2008 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-18266764
6.
gamma-Secretase dependent production of intracellular domains is reduced in adult compared to embryonic rat brain membranes.
PLoS One
; 5(3): e9772, 2010 Mar 19.
Artigo
Inglês
| MEDLINE | ID: mdl-20333303
7.
Synaptic and endosomal localization of active gamma-secretase in rat brain.
PLoS One
; 5(1): e8948, 2010 Jan 28.
Artigo
Inglês
| MEDLINE | ID: mdl-20126630
8.
Rat brain gamma-secretase activity is highly influenced by detergents.
Biochemistry
; 46(25): 7647-54, 2007 Jun 26.
Artigo
Inglês
| MEDLINE | ID: mdl-17536783